Bridge Lab: Brain and Behavior in Children with RASopathies

Bridge Lab: Brain and Behavior in Children with RASopathies New Brain Imaging Research Opportunity for Children

Happy Holidays and a Happy New Year from all of us at BRIDGE Lab!Here’s to a New Year filled with inspiration, collabora...
12/27/2024

Happy Holidays and a Happy New Year from all of us at BRIDGE Lab!

Here’s to a New Year filled with inspiration, collaboration, and continued progress.

Curious about the SOS1 mutation in Noonan Syndrome and its impact on children’s mental health and cognitive development?...
12/27/2024

Curious about the SOS1 mutation in Noonan Syndrome and its impact on children’s mental health and cognitive development?

Check out our webinar where Dr. Tamar Green explores what we know about SOS1 mutations and their role in shaping neurodevelopmental outcomes.

https://www.youtube.com/watch?v=pJRHzQ9cFNY

Our latest paper using advanced diffusion MRI shows the widespread effects of neurofibromatosis type 1 (NF1) and Noonan ...
12/16/2024

Our latest paper using advanced diffusion MRI shows the widespread effects of neurofibromatosis type 1 (NF1) and Noonan syndrome (NS) on brain microstructure in affected children.

88 children completed an MRI scan including diffusion MRI and we subsequently modeled the data using advanced models (NODDI and DKI) to examine group differences in subcortical regions and white matter tracts.

Our results showed significantly reduced neurite density (axons and dendrites) in subcortical regions in NF1, particularly in the thalamus and hippocampus. Linear discriminant analysis reinforced these findings, showing an ability to distinguish the NF1 subjects with 97% accuracy.

We found widespread reductions in neurite density and mean kurtosis (indicating reduced tissue complexity) in NF1 and NS across all 39 white matter tracts investigated. Of these tracts, the middle cerebellar peduncle showed the greatest differences between the three groups.

Ultimately, we found NODDI and DKI demonstrate specificity for identifying condition-specific brain alterations. Our findings align with preclinical evidence and highlight the potential of advanced diffusion models for elucidating brain-behavior relationships.

The webinar is one day away! Register now if you're interested in joining us.
12/13/2024

The webinar is one day away! Register now if you're interested in joining us.

What do we know about the SOS1 mutation in Noonan Syndrome? How does it impact children’s mental health and cognitive development?

Join BRIDGE Lab on December 14th, 2024, at 10 AM PT / 1 PM ET as Dr. Tamar Green dives deep into these questions.

Register here: https://forms.gle/jX5RXY4sNv4nPZbx7

Last week, Dr. Julia Plank, a postdoctoral fellow in BRIDGE Lab, led our journal club discussion. Here’s a glimpse at th...
12/08/2024

Last week, Dr. Julia Plank, a postdoctoral fellow in BRIDGE Lab, led our journal club discussion. Here’s a glimpse at the incredible team driving our work forward!

The holidays can be a joyful but challenging time for families navigating neurodevelopmental conditions. BRIDGE Lab is h...
12/03/2024

The holidays can be a joyful but challenging time for families navigating neurodevelopmental conditions. BRIDGE Lab is here to help with resources that support mental health and well-being during this busy season. Visit our website for tips, tools, and guides for caregivers and families: https://med.stanford.edu/bridge-lab/resources.html

This week, we’re feeling especially grateful for the families, children, and caregivers who partner with us to advance o...
11/27/2024

This week, we’re feeling especially grateful for the families, children, and caregivers who partner with us to advance our research. From all of us at BRIDGE Lab, thank you for being part of our community.

What do we know about the SOS1 mutation in Noonan Syndrome? How does it impact children’s mental health and cognitive de...
11/19/2024

What do we know about the SOS1 mutation in Noonan Syndrome? How does it impact children’s mental health and cognitive development?

Join BRIDGE Lab on December 14th, 2024, at 10 AM PT / 1 PM ET as Dr. Tamar Green dives deep into these questions.

Register here: https://forms.gle/jX5RXY4sNv4nPZbx7

Excited to share Dr. Green's recording for her recent Grand Rounds presentation in the Pediatric Department at Riley Chi...
11/17/2024

Excited to share Dr. Green's recording for her recent Grand Rounds presentation in the Pediatric Department at Riley Children’s Health. Check it out here:

BRIDGE Lab is proud to share that Dr. Tamar Green was recently invited to present grand rounds in the Pediatric Departme...
11/12/2024

BRIDGE Lab is proud to share that Dr. Tamar Green was recently invited to present grand rounds in the Pediatric Department at Riley Children’s Health! Dr. Green presented on 'Applying a Genetic-First Approach in Psychiatry: The Case of RASopathies,'

A special thanks to Dr. Wade Clapp for extending the invitation, and to Dr. Steven D. Rhodes, MD, PhD, fellow Francis S. Collins Scholar.

November is  , and at BRIDGE Lab, we want to celebrate and support the incredible caregivers who play such a vital role ...
11/09/2024

November is , and at BRIDGE Lab, we want to celebrate and support the incredible caregivers who play such a vital role in their loved ones' lives. Caregivers make the journey possible for children with rare genetic and neurodevelopmental conditions. To all caregivers, thank you for the resilience you show every day!

If you’re a caregiver, check out our website for on-demand webinars about advocating for your child and mental health resources: https://med.stanford.edu/bridge-lab/resources.html

Congratulations to Dr. Yaffa Serur on her presentation at the symposium on Phenotypic, Genetic, and Clinical Heterogenei...
10/21/2024

Congratulations to Dr. Yaffa Serur on her presentation at the symposium on Phenotypic, Genetic, and Clinical Heterogeneity in Neuropsychiatric Disorders last week!

Her talk on Imaging Genetics in Rasopathies highlighted the importance of addressing heterogeneity in neuropsychiatric disorders.

We are still recruiting participants with Noonan Syndrome, specifically SOS1. If you are interested, please register her...
10/11/2024

We are still recruiting participants with Noonan Syndrome, specifically SOS1. If you are interested, please register here: https://redcap.link/lphthuz9
Noonan Syndrome Foundation Family's With Noonans SyndromeRASopathies Family (formerly Noonan Syndrome Family)Noonan Syndrome Foundation

🚨 Final Call for Participants with SOS1! 🚨
Stanford University is wrapping up an important study on Noonan Syndrome, focusing on children with the SOS1 gene mutation. If your child is aged 5-17 and has this specific mutation, you have the chance to learn more about their brain development through a free, in-depth neuropsychological evaluation. Families will receive $100 Honorarium for their time.

Register now: https://redcap.link/lphthuz9

10/10/2024

Today, on World Mental Health Day, we’re reminded of how vital mental health is for everyone, especially the children and families we work with at the BRIDGE Lab. Our research focuses on understanding how genetics impact brain development and neuropsychiatric conditions, with the ultimate goal of improving children’s mental health and quality of life. 💚

Last week, we celebrated Rosh Hashanah, the Jewish New Year, at the lab! 🍎🍯 Wishing everyone a sweet and joyful year ahe...
10/09/2024

Last week, we celebrated Rosh Hashanah, the Jewish New Year, at the lab! 🍎🍯 Wishing everyone a sweet and joyful year ahead—may this year be even better than the last.

🚨 Final Call for Participants with SOS1! 🚨Stanford University is wrapping up an important study on Noonan Syndrome, focu...
09/25/2024

🚨 Final Call for Participants with SOS1! 🚨
Stanford University is wrapping up an important study on Noonan Syndrome, focusing on children with the SOS1 gene mutation. If your child is aged 5-17 and has this specific mutation, you have the chance to learn more about their brain development through a free, in-depth neuropsychological evaluation. Families will receive $100 Honorarium for their time.

Register now: https://redcap.link/lphthuz9

Remote study opportunity for children with Noonan Syndrome!Would you like to participate in a study from the comfort of ...
09/13/2024

Remote study opportunity for children with Noonan Syndrome!

Would you like to participate in a study from the comfort of your own home? Join our study, which focuses on children with Noonan Syndrome, aged 5-16, and their parents.

The study involves a non-invasive saliva test for the child and both parents, as well as a comprehensive neuropsychological evaluation for the child.

You can conveniently participate from the comfort of your own home. We offer a $50 honorarium and a thorough neuropsychological evaluation for your participation.

Learn more and check your eligibility here: http://redcap.link/nf1_study
Noonan Syndrome Foundation

Read Dr. Monica Siqueiros-Sanchez's latest paper on the impact of pathogenic variants of the Ras–mitogen-activated prote...
09/11/2024

Read Dr. Monica Siqueiros-Sanchez's latest paper on the impact of pathogenic variants of the Ras–mitogen-activated protein kinase pathway on major white matter tracts in the human brain.

Using diffusion neuroimaging, we show that pathogenic variants in the Ras-Mitogen-activated-protein-kinase pathway associated with Noonan syndrome and Neurofibromatosis type 1, are associated with compromised white-matter structural connectivity in the developing brain. TBSS and tract-based (TRACULA) analyses showed that these syndromes exhibited distinct spatial patterns and effect magnitudes on white-matter microstructure in intra-hemispheric and inter-hemispheric tracts, as indicated by fractional anisotropy and axial diffusivity, but also overlapping spatial effects in widespread radial and mean diffusivity.

Read the paper here: https://academic.oup.com/braincomms/article/6/4/fcae274/7733452

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