18/06/2026
Pneumomediastinum is the presence of air in the mediastinum.
This can occur secondary to trauma, or any condition in which air leaks into the chest cavity from the airways, lungs or bowels.
Spontaneous pneumomediastinum occurs without any obvious cause. Secondary pneumomediastinum has various potential underlying causes including respiratory disease, trauma, Boerhaave syndrome, Valsalva manoeuvre, childbirth, scuba diving, and substance abuse2.
Recently, there has been a global rise in the incidence of substance misuse. Nitrous oxide is a popular recreational drug amongst teenagers and young adults.
Nitrous oxide induced pneumomediastinum can be explained by forceful inhalation from a cannister increasing the intrapulmonary pressure and causing a barotrauma effect on the alveoli resulting in air leaks into the intra-thoracic cavity3.
Physical examination may reveal presence of crepitus on the anterior chest wall sometimes tracking to the paravertebral fascia around the neck.
Hamman’s crunch is an audible crunching or clicking sound on auscultation, synchronous with the heartbeat4.
The diagnosis of pneumomediastinum can be confirmed by chest x-ray or CT Thorax. While dependent on aetiology, it usually has a good prognosis.
Treatment:
Admission for minimum 24 hours observation
High flow oxygen (improves the reabsorption of free air by 6-fold)
Anti-tussives
Adequate analgesia
Advise these patients to avoid any strenuous exercise for a minimum of 4 weeks, and to avoid air travel for 3 weeks.
Rarely complications such as worsening pneumomediastinum, tension pneumomediastinum, pneumothorax or extensive subcutaneous emphysema could necessitate a drain and, occasionally, a thoracotomy for decompression.
Key Learning Points
Nitrous oxide use is a potential underlying cause of spontaneous pneumomediastinum.
Hamann’s sign in the absence of any anomaly on CXR should warrant further imaging such as CT Thorax to identify the underlying pathology.
After discharge from hospital, advice should be given to patients with pneumomediastinum to avoid air travel and strenuous exercise for an average of 4 weeks.