12/11/2015
We are looking for healthy, non-smoking, middle-aged (40-60 yrs) male overweight/obese volunteers who have no history of diabetes and cardiovascular disease.
Purpose: The aim of this project is to investigate whether impairment in the action of insulin to promote the use of glucose in skeletal muscle (insulin resistance) as a result of oral ingestion of a liquid meal rich in saturated fat is linked to reduced ability of muscles to synthesise new protein in response to dietary protein intake, which ultimately may compromise maintenance of muscle size and quality of life. We will also test the hypothesis that partially replacing the saturated fat content in the liquid meal with fish oil derived fatty acids will ameliorate these negative effects.
What does the study involve? There will be 4 experimental visits to the laboratory, one lasting ~45 min (health screening visit) and the other three lasting ~8.5 hrs each. In each of those 3 visits (which will take place at least 1 week apart) the subjects will undergo a dietary intervention study requiring the consumption of oral meals with different fat content (see below) four hours before the ingestion of a drink containing milk protein and sugar. Regular small volume blood samples will be obtained during those trials.
During the main visits, all subjects will ingest a hot, chocolate-flavoured drink consisting of either the solid fat portion of palm oil (saturated fat trial), a similar drink in which part of the saturated fat content will be replaced with fish oil (fish oil trial), or water (control trial).
This study has been approved by the University of Nottingham Medical School Ethics Committee.
Contact for Further Information:
Dr Kostas Tsintzas,
Tel. (office) 0115 8230127, Email: [email protected]
Dr Francis Stephens,
Tel. (office) 0115 8230398, Email: [email protected]