Rainero Lab

02/07/2025

Fantastic lab walk in the Peak District!

02/07/2025

Welcome to the lab Fatmagul!! Joining the lab summer walk is a great way to start!

12/06/2025

New addition to our lab's PhD Wall of Fame - Bian 🇸🇾

05/06/2025

Congratulations to Bian on passing her PhD viva!!! Well deserved!

18/12/2024

Our recent paper is now highlighted in :

17/12/2024

Our latest paper is out!!!
Novel kinase regulators of extracellular matrix internalisation identified by high-content screening modulate invasive carcinoma cell migration

This study identifies novel kinase regulators of extracellular matrix (ECM) internalization through a high-content screen, characterizing the α2β1 integrin/p38 signaling axis as required for the internalization integrin-bound ECM, which modulates cell migration and invasion in breast, ovarian and ...

20/09/2024

Yay!!! Bian won a best poster prize 🏆 at the NECB2024!!!

12/09/2024

Great presentation by Rachele at the 3rd year PGR symposium today + a fantastic 'express my PhD' artwork!!

12/07/2024

New preprint from our lab by Sherry & Rachele: "The protease ADAMTS5 controls ovarian cancer cell invasion, downstream of Rab25"

Ovarian cancer is the 3rd most common gynaecological malignancy worldwide, with a 5-year survival rate of less than 30% in the presence of metastasis. Metastatic progression is characterised by extensive remodelling of the extracellular matrix, primarily mediated by secreted matrix metalloproteinase...

12/07/2024

Huge congratulations to Dr Sherry on brilliantly passing her PhD viva!!!

17/01/2024

🎉 Excited to share our latest article published in :

Breast tumors are embedded in a collagen-rich extracellular matrix (ECM) network, where nutrients are scarce due to limited blood flow and elevated tumor growth. This study shows that invasive breast cancer cells use macropinocytosis-dependent uptake and lysosomal degradation of ECM to promote their...

15/01/2024

New preprint from our lab, by Montse Llanses Martínez, Keqian Nan, , Rachele Bacchetti, Shengnan Yuan and : internalisation of integrin-bound modulates invasive carcinoma cell migration

The interaction between cancer cells and the extracellular matrix (ECM) plays a pivotal role in tumour progression. While the extracellular degradation of ECM proteins has been well characterised, ECM endocytosis and its impact on cancer cell progression, migration and metastasis is poorly understoo...