Computational Biology Institute

Computational Biology Institute Established in 2012 on The George Washington University's Virginia Science and Technology Campus in Ashburn, VA, the Computational Biology Institute focuses on research in informatics and biodiversity, systems biology, and translational medicine.

The Computational Biology Institute (CBI) at the George Washington University (GW) is an interdisciplinary effort building on GW’s strengths in life sciences and computational science, in addition to the wealth of research centers in the Washington, DC-area. By bringing together GW experts and scholars from partner institutions, CBI will provide cutting edge research, enable broad educational activities in computational biology and provide computational biology services to university researchers and public and private partners.

New posting at Smithsonian Institution: Biological Science Laboratory Technician (Analytical Biology)https://www.usajobs...
02/12/2018
Biological Science Laboratory Technician

New posting at Smithsonian Institution: Biological Science Laboratory Technician (Analytical Biology)

https://www.usajobs.gov/GetJob/ViewDetails/490597500

This position will provide technical support for molecular genetics research and collections in the Laboratories of Analytical Biology (L.A.B.), National Museum of Natural History (NMNH), Smithsonian Institution, Washington, DC (primary duty station is at the Natural History Museum in DC but some wo...

Professor Keith Crandall, Director of the Computational Biology Institute, and Assistant Professor Marcos Perez-Losada c...
02/05/2018
Phylogeography reveals unexpectedly low genetic diversity in a widely distributed species: the case of the freshwater crab Aegla platensis (Decapoda: Anomura) | Biological Journal of the Linnean Society | Oxford Academic

Professor Keith Crandall, Director of the Computational Biology Institute, and Assistant Professor Marcos Perez-Losada co-authored an article published in the Biological Journal of the Linnean Society, titled "Phylogeography reveals unexpectedly low genetic diversity in a widely distributed species: the case of the freshwater crab Aegla platensis (Decapoda: Anomura)", which was published on February 3rd, 2018. The article is the result of an investigation into the genetic diversity of aeglids, which usually have a narrow phylogeographical distribution. Aegla platensis, on the other hand, is widely distributed geographically, but of 17 populations examined from Argentina and Brazil, only one might represent a new species, while the others belong to a single species, on the basis of three molecular markers.

Habitat and taxon-specific properties could affect the propensity for cryptic species to be formed. For example, anomurans of the genus Aegla possess characteristics that suggest the existence of cryptic diversity. The widely distributed species Aegla platensis, besides having been considered paraph...

The Computational Biology Institute is hiring a Research Scientist for our Next-Gen Sequencing Core!
02/02/2018
Research Scientist, NGS Core

The Computational Biology Institute is hiring a Research Scientist for our Next-Gen Sequencing Core!

The Computational Biology Institute in the Milken Institute School of Public Health at The George Washington University is seeking a highly-motivated candidate for a position as a Research Scientist with the Next-Gen Sequencing (NGS) Core. A successful applicant will be ready and willing to assist w...

The Computational Biology Institute is hiring a postdoc! https://www.gwu.jobs/postings/49199 Come work with us!
02/01/2018
Postdoctoral Scientist

The Computational Biology Institute is hiring a postdoc! https://www.gwu.jobs/postings/49199 Come work with us!

The Computational Biology Institute in George Washington University's Milken Institute School of Public Health is seeking a highly motivated Postdoctoral Scientist (PDS). The work performed by the PDS will contribute to our diverse research program devoted to the investigation of: i) the role of mic...

Assistant Professor Marcos Perez-Losada co-authored an article published in Parasites and Vectors on January 25th, 2018....
01/30/2018
Phylogenetic analysis of apicomplexan parasites infecting commercially valuable species from the North-East Atlantic reveals high levels of diversity and insights into the evolution of the group

Assistant Professor Marcos Perez-Losada co-authored an article published in Parasites and Vectors on January 25th, 2018. The article, titled "Phylogenetic analysis of apicomplexan parasites infecting commercially valuable species from the North-East Atlantic reveals high levels of diversity and insights into the evolution of the group," deals with the apicomplexa, organisms from aquatic environments which are understudied relative to their terrestrial counterparts. The seminal work assessing the phylogenetic relations of fish-infecting lineages is mostly based on freshwater hosts. The taxonomic uncertainty of some apicomplexan groups, such as the coccidia, is high and many genera were recently shown to be paraphyletic, questioning the value of strict morphological and ecological traits for parasite classification. For this article, the authors surveyed the genetic diversity of the Apicomplexa in several commercially valuable vertebrates from the North-East Atlantic, including farmed fish.

The Apicomplexa from aquatic environments are understudied relative to their terrestrial counterparts, and the seminal work assessing the phylogenetic relations of fish-infecting lineages is mostly based on freshwater hosts. The taxonomic uncertainty of some apicomplexan groups, such as the coccidia...

Professor Keith Crandall, Director of the Computational Biology Institute, was cited in a recent article in The Economis...
01/24/2018
Sequencing the world

Professor Keith Crandall, Director of the Computational Biology Institute, was cited in a recent article in The Economist on January 23rd, 2018, "Sequencing the world," as one of the 23 participants in a research project to "gather DNA sequences from specimens of all complex life on Earth" as part of the Earth BioGenome Project. Dr. Crandall's work on the EBP is at the heart of the work being done by many members of the Computational Biology Institute at The George Washington University. Dr. Crandall participated in an interview with journalists from The Economist at the Smithsonian, leading to the publication of the article.

How to map the DNA of all known plants and animal species on Earth

01/17/2018
10/23/2017
10/20/2017

Marcos Perez-Losada and Gustav Nino to Receive NIH-R21

Assistant Professor Marcos Perez-Losada is co-investigator, along with Gustav Nino as the primary investigator, in an exploratory/developmental research grant titled: “Exosomal miR-155 Regulates Airway Epithelial Immune Responses in Infants with Rhinovirus Infection.” The grant aims to establish the immunomodulatory role of miR-155 in airway epithelial cells of infants in an effort to translate basic and clinical research into novel therapeutic strategies to improve health outcomes in young children. Perez-Losada will provide bioinformatics data analysis for the project, with the goal of characterizing the exosomal miR-155 secretory response during in-vivo RV infection and determine its association with airway immune responses and clinical disease.

Today at 12pm:
10/16/2017

Today at 12pm:

The CBI was out at the Nationals game last night!
09/13/2017

The CBI was out at the Nationals game last night!

Overexpressed somatic alleles are enriched in functional elements in Breast Cancer
08/23/2017
Overexpressed somatic alleles are enriched in functional elements in Breast Cancer

Overexpressed somatic alleles are enriched in functional elements in Breast Cancer

Asymmetric allele content in the transcriptome can be indicative of functional and selective features of the underlying genetic variants. Yet, imbalanced alleles, especially from diploid genome regions, are poorly explored in cancer. Here we systematically quantify and integrate the variant allele f...

08/18/2017
Crandall and Stern Published in Evolution | Computational Biology Institute | The George Washington University

Keith Crandall and CBI student David Stern were published in Evolution! Their article suggests caves may not be such "evolutionary dead ends" after all:

Professor Keith Crandall co-authored "Phylogenetic evidence from freshwater crayfishes that cave adaptation is not an evolutionary dead-end" with Computational Biology Institute student David Stern, which was published in Evolution on August 14th, 2017.

07/31/2017
6th Annual Georgetown Biomedical Informatics Symposium | Computational Biology Institute | The George Washington University

Register now for the ICBI Innovation Center for Biomedical Informatics- Georgetown University 6th Annual Biomedical Informatics Symposium!

The Innovation Center for Biomedical Informatics at Georgetown University will be hosting the 6th Annual Georgetown Biomedical Informatics Symposium on Friday, October 27th, 2017, from 8am to 6pm. You can register now at icbi.georgetown.edu/symposium. The keynote speaker will be Patricia Flatley Bre...

07/10/2017
Marcos Perez-Losada Published in Zoological Journal of the Linnean Society | Computational Biology Institute | The George Washington University

And Marcos Perez-Losada was published twice in the same issue!

Assistant Research Professor Marcos Perez-Losada co-authored the study, "Multigene phylogeny reveals two new isolated and relic earthworm genera (Oligochaeta: Lumbricidae)," which was published in the Zoological Journal of the Linnean Society on July 3rd, 2017. Phylogenetic analysis has revealed man...

07/10/2017
Keith Crandall and Marcos Perez-Losada Published in Zoological Journal of the Linnean Society | Computational Biology Institute | The George Washington University

Keith Crandall and Marcos Perez-Losada were published in the Zoological Journal of the Linnean Society!

Professor Keith Crandall and Assistant Research Professor Marcos Perez-Losada co-authored the study, "Looks can be deceiving: species delimitation reveals hidden diversity in the freshwater crab Aegla longirostri (Decapoda: Anomura)," which was published in the Zoological Journal of the Linnean Soci...

06/12/2017
Hughes, Nguyen, and Bernot Published in Ecology and Evolution | Computational Biology Institute | The George Washington University

Lily Hughes, Bryan Nguyen, and James Bernot were published in Ecology and Evolution! Great work! https://cbi.gwu.edu/hughes-nguyen-and-bernot-published-ecology-and-evolution

Lily Hughes, Bryan Nguyen, and James Bernot, co-authored an article, "Transcriptomic differentiation underlying marine-to-freshwater transitions in the South American silversides Odontesthes argentinensis and O bonariensis (Atheriniformes)," published in Ecology and Evolution on June 7th, 2017. You…

Professor Keith Crandall and PhD student David Stern co-authored the study, "DNA Barcoding analysis of seafood accuracy ...
05/01/2017
DNA Barcoding analysis of seafood accuracy in Washington, D.C. restaurants

Professor Keith Crandall and PhD student David Stern co-authored the study, "DNA Barcoding analysis of seafood accuracy in Washington, D.C. restaurants," which was published in PeerJ on April 25th, 2017. In this study, as part of a preliminary legal investigation exploring the viability of a lawsuit under Washington D.C.’s CPPA, the authors sampled the barcoding region of the COI gene to test the identity of commonly mislabeled seafood products from six restaurants in Washington, D.C. They took multiple approaches to identify the sampled specimens. While they reported multiple potentially mislabeled food items, the majority of our tested items were either correctly labeled or were identified as legally acceptable species for the food labeling.

https://peerj.com/articles/3234/

In Washington D.C., recent legislation authorizes citizens to test if products are properly represented and, if they are not, to bring a lawsuit for the benefit of the general public. Recent studies revealing the widespread phenomenon of seafood substitution across the United States make it a fertil...

CBI DIrector Keith Crandall quoted in the Washington Post!
04/25/2017
Your Best Life with The Washington Post

CBI DIrector Keith Crandall quoted in the Washington Post!

When you order ahi tuna tartare at a D.C. restaurant, can you be sure that’s what you’re getting?

04/07/2017
www.researchgate.net

Assistant Research Professor Marcos Perez-Losada co-authored the article, "Multilocus sequence typing of pathogens: Methods, analyses, and applications," which was published in Genetics and Evolution of Infectious Diseases in April 2017. The article examines MLST, which was built on the well-established population genetic concepts and methods of the multilocus enzyme electrophoresis (MLEE) technique, but provides significant advantages over this and other typing approaches. MLST has become a standard and flexible approach for characterizing bacteria and some eukaryotes mainly due to the existence of comprehensive databases and its broad implementation in clinical laboratory settings, from basic research laboratories to core sequencing facilities.

https://www.researchgate.net/profile/Eduardo_Castro-Nallar/publication/313426098_Multilocus_Sequence_Typing_of_Pathogens_Methods_Analyses_and_Applications/links/589a1cf54585158bf6f8ab1f/Multilocus-Sequence-Typing-of-Pathogens-Methods-Analyses-and-Applications.pdf

04/04/2017

Assistant Research Professor Marcos Perez-Losada co-authored the study, "Nasopharyngeal microbiome in premature infants and stability during rhinovirus infection," which was published in the Journal of Investigative Medicine on March 31st, 2017. The study considered how the nasopharyngeal (NP) microbiota of newborns and infants plays a key role in modulating airway inflammation and respiratory symptoms during viral infections.

http://jim.bmj.com/content/early/2017/03/31/jim-2017-000414

Read the latest article from CBI members Marcos Perez-Losada, Eduardo Castro-Nallar, Matthew Bendall, and Keith Crandall...
07/01/2015
Dual Transcriptomic Profiling of Host and Microbiota during Health and Disease in Pediatric Asthma

Read the latest article from CBI members Marcos Perez-Losada, Eduardo Castro-Nallar, Matthew Bendall, and Keith Crandall titled "Dual Transcriptomic Profiling of Host and Microbiota during Health and Disease in Pediatric Asthma".

Background High-throughput sequencing (HTS) analysis of microbial communities from the respiratory airways has heavily relied on the 16S rRNA gene. Given the intrinsic limitations of this approach, airway microbiome research has focused on assessing bacterial composition during health and disease, a…

Congratulations to CBI's first doctoral graduate, Dr. Eduardo Castro-Nallar! Eduardo will continue working with CBI unti...
05/18/2015

Congratulations to CBI's first doctoral graduate, Dr. Eduardo Castro-Nallar! Eduardo will continue working with CBI until July when he returns to his native Chile to accept a position in academia.

CBI affiliate Dr. Raja Mazumder discusses working with Colonial One and genomics data in partnership with NIH's Internet...
03/12/2014
NIH and GW Collaborate to Accelerate Genomics Research Using Internet2’s 100G Network | GW Today...

CBI affiliate Dr. Raja Mazumder discusses working with Colonial One and genomics data in partnership with NIH's Internet2.

Researchers running genomic analyses at the George Washington University’s Colonial One High Performance Computing Center will pilot ultra high-speed 40 gigabit per second data transfers from the National Institutes of Health’s National Library of Medicine, using new 100 gigabit per second links to…

Please join us in congratulating Dr. Keith Crandall on being named a fellow of the American Association for the Advancem...
11/27/2013
Computational Biology Institute Director Honored for Advancing Science | GW Today | The George...

Please join us in congratulating Dr. Keith Crandall on being named a fellow of the American Association for the Advancement of Science for his contributions to the field of evolutionary biology!

The full list of fellows can be found here: http://www.aaas.org/news/releases/2013/1125_fellows.shtml

Keith Crandall, director of George Washington University’s Computational Biology Institute, has been named a fellow of the American Association for the Advancement of Science (AAAS) for his contributions to phylogenetics and evolutionary biology, particularly for broad applications to natural histor...

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