UGA Non-Invasive Muscle Physiology Lab

UGA Non-Invasive Muscle Physiology Lab We are dedicated to developing new non-invasive ways to evaluate neuromuscular and cardiovascular diseases. We are also student oriented. The Exercise Vascular Biology Laboratory (1400 square ft) is equipped to study blood flow and oxygen delivery to skeletal muscle.

Dr. McCully is the director of this laboratory. Research is focused on determining whether flow limitations or impaired vascular function exist in various patient populations. The goal of these measurements is to determine if vascular limitations impair muscle metabolism, and whether vascular limitations can be reduced with increased physical activity. The key to these studies are the use of noninvasive measurement tools that are powerful yet applicable to frail populations. The measurement tools include Doppler ultrasound to measure arterial blood flow, near-infrared spectroscopy to measure oxygen delivery, and magnetic resonance spectroscopy to measure muscle metabolism. Current study populations include patients with chronic fatigue syndrome, acquired spinal cord injury, and suspected peripheral arterial disease.

Mission: Improve the quality of life for people with chronic illnesses and injuries. We seek to develop improved methods of evaluating skeletal muscle function, including muscle blood flow, muscle metabolism, and muscle composition. We also seek to improve and better understand therapies to enhance skeletal muscle function and whole body health. We are a student based laboratory that also seek to enhance student education.

Operating as usual

Everyone please join us for Adeola Sani's dissertation defense. email mccully@uga.edu for link
11/16/2020

Everyone please join us for Adeola Sani's dissertation defense. email [email protected] for link

Everyone is welcome. The lab is hosting a discussion of exercise and MS. We are particularly interested in talking wit...
11/11/2020

Everyone is welcome. The lab is hosting a discussion of exercise and MS. We are particularly interested in talking with and potentially helping people with MS become more active.

11/10/2020

NOTICE: Adeola Sanni will defend her dissertation Next Monday at 3pm. November 16th. Please join us. Email [email protected]

07/06/2020

And I just found the final version of this paper as well.

Reliability and reproducibility of a four arterial occlusions protocol for assessing muscle oxidative metabolism at rest and after exercise using near-infrared spectroscopy. Chuan Zhang, Brandon Hodges and Kevin K McCully Published 29 June 2020 • © 2020 Institute of Physics and Engineering in Medicine Physiological Measurement, Volume 41, Number 6

07/06/2020

Some lab activity during the break!

Jones, E.G., K.K. McCully. Validation of a 5 Minute 5 Hz protocol for Muscle Specific Endurance. Medical Research Archives. Accepted July 1, 2020.

Liss, C., A.A. Sanni-Ajibaye, K.K. McCully. Endurance of the Dorsal and Ventral Muscles in the Neck. Journal Functional Morphology and Kinesiology. Accepted July 6, 2020.

Pryor, E.K., H.R. Wachsmuth, K.K. McCully. Evaluation of a 5-Minute Endurance Test of Human Diaphragm Muscle. Medical Research Archives. Accepted July 1, 2020.

Slowly and safely, getting ready for Phase I of reopening. This is our lab check in station. My temperature today was ...
06/10/2020

Slowly and safely, getting ready for Phase I of reopening. This is our lab check in station. My temperature today was 97.5 F. :^)

Perhaps it is time to get back to doing experiments? I hope you are all doing well and staying safe. There is an inter...
05/31/2020

Perhaps it is time to get back to doing experiments? I hope you are all doing well and staying safe. There is an internet project of people duplicating famous artwork, this is my attempt (Ph.D. comics).

The lab does have 4 papers under review with a few more being prepared. We will start student class projects soon. Hopefully we can resume real experiments in not too long.

I will also miss the lab. How about everyone else?https://www.the-scientist.com/news-opinion/opinion-the-isolated-scien...
05/19/2020
Opinion: The Isolated Scientist

I will also miss the lab. How about everyone else?

https://www.the-scientist.com/news-opinion/opinion-the-isolated-scientist-67544?utm_campaign=TS_DAILY%20NEWSLETTER_2020&utm_source=hs_email&utm_medium=email&utm_content=88150398&_hsenc=p2ANqtz-_l488KRFMZJ3bHWg69sehFVBHmJuMVrgAZ21nPqLHfn-3xMxdKvo0QP-ew1djhFv-RpG8cOE4IQ13cVUw1DN1SLmU23Q&_hsmi=88150398

Among the disruptions and pain caused by the COVID-19 pandemic, researchers are dealing with a sudden halt in in-person interactions.

05/05/2020

Dr. Zhang's first paper with our lab! Nice job (and Brandon too).

"Reliability and Reproducibility of a Four Arterial Occlusions Protocol for Assessing Muscle Oxidative Metabolism at Rest and after Exercise using Near-infrared Spectroscopy" by Zhang, Chuan; Hodges, Brandon; McCully, Kevin
Article reference: PMEA-103532.R2

Jimena did a great job of presenting her Young Dawgs experiments this semester It was done via zoom, but there were a f...
04/27/2020

Jimena did a great job of presenting her Young Dawgs experiments this semester It was done via zoom, but there were a few lab members in the 'audience'.

Everyone is welcome to join us. Lets all watch our labmate Jimena present her research. I will log on about 1:35pm and...
04/25/2020
Join our Cloud HD Video Meeting now

Everyone is welcome to join us. Lets all watch our labmate Jimena present her research. I will log on about 1:35pm and hope to catch her presentation. Once again, bonus for asking questions. BTW, we have ordered fit bits to continue this study this fall (and maybe summer)

The Zoom Code to join the 1:00 meeting is
https://zoom.us/j/94611688845

The schedule of presenters will be:

1:00--Beatrice Acheson—Regenerative Medicine
1:20--Casey Pendley--Dance
1:40--Jimena Somilleda--Kinesiology
2:00--Alexander Robinson--Education
2:20--Braden Delamater—Journalism

Zoom is the leader in modern enterprise video communications, with an easy, reliable cloud platform for video and audio conferencing, chat, and webinars across mobile, desktop, and room systems. Zoom Rooms is the original software-based conference room solution used around the world in board, confer...

04/21/2020

CURO 2020 It maybe a virtual research meeting, but our lab is there in numbers. Thanks to the whole lab for their work and to these students for putting together their posters. I am not sure how one gets the privilege of viewing the posters, but if you can, add a comment.

• Andrawes, Karen
Evaluation of Respiratory Strength Using Spirometry
Karen Andrawes, CURO Research Assistant

• Hodges, Brandon Parker
Noninvasive Measurement of Muscle Oxidative Metabolism at Rest and After Exercise
Brandon Hodges, CURO Research Assistant

• Hooks, Olivia Jean
Video Camera Analysis to Capture Muscle Specific Endurance
Olivia Jean Hooks, CURO Research Assistant

• Jones , Emily Gardner
Evaluation of Perceived Fatigue vs. Muscle Fatigue in a Comparison of Older and Younger Adults
Emily Gardner Jones, CURO Summer Fellow

• Liss, Cameron Marie
The Endurance of the Dorsal and Ventral Neck Muscles Compared to the Vastus Lateralis
Cameron Liss, CURO Research Assistant

Madhusudan, Aditi (2)
The Effect of Exercise-Induced Gastrocnemius Muscle Injury on Resting Muscle Metabolism and Mitochondrial Capacity
Aditi Madhusudan, CURO Research Assistant


• Yanek, Nicholas McKay
Fatigue of the Diaphragm Muscle Through the Right and Left Phrenic Nerves
Nicholas Yanek, CURO Research Assistant

More articles on research in our current world. Please post your own experiences! https://www.the-scientist.com/news-o...
04/09/2020
Opinion: Lab Work Under Isolation

More articles on research in our current world. Please post your own experiences!

https://www.the-scientist.com/news-opinion/opinion-lab-work-under-isolation-67398?utm_campaign=TS_OTC_2020&utm_source=hs_email&utm_medium=email&utm_content=86099889&_hsenc=p2ANqtz-_jD8dv7eMA1_rcw-f-fUr7qmNMin22qyj3_fMRdJk8ouFxm36yRFMot3G3o_1CkKQ-WEtghvlk2v6RTrON1XzQypoc5A&_hsmi=86099889

Here's how my group put our research on pause and how we've continued our work from home.

04/08/2020

Congratulations to Faith for receiving the Abbie deLoach Memorial Scholarship. Too bad we can't have an awards ceremony (for awhile anyway) or a lab party.

I hope everyone is staying active and healthy during our break from school. Even if you just walk around the house (as ...
03/23/2020

I hope everyone is staying active and healthy during our break from school. Even if you just walk around the house (as I did)

03/21/2020

The lab is closed for the time being. Remember to stay safe and healthy. CURO will have a virtual poster meeting and we will resume our research activities remotely next week.

03/14/2020

Congratulations to Brad for his paper.

Dear Dr. Willingham (cc: co-authors and others),

On behalf of Francois Bethoux, MD, Editor in Chief of the International Journal of MS Care, I am pleased to inform you that your article “Effects of Treadmill Training on Muscle Oxidative Capacity and Endurance in People with Multiple Sclerosis with Significant Walking Limitations” (published in our July/August 2019 issue) has been selected as this year’s recipient of the Herndon Award for Outstanding IJMSC Article. This award, which is named for IJMSC founding editor Robert M. Herndon, is given by the Consortium of Multiple Sclerosis Centers (CMSC) for the best article published in the journal during the preceding calendar year. Your article was scored highest by a four-person judging panel assigned by Dr. Bethoux.

This award is scheduled to be announced and presented at the 2020 CMSC Annual Meeting in Orlando (May 27-May 30 [currently still on but coronavirus situation being monitored]). Please let me know if you, or one of your coauthors, will be present to accept the award.

The award carries a $1000 stipend for you and your co-authors to use/split as you see fit. The journal’s publisher, Delaware Media Group, will issue a check in your name.

03/12/2020

The University System of Georgia, has communicated with the Presidents of all of the USG’s 26 institutions. Per the USG’s direction, the University of Georgia will temporarily suspend instruction for two weeks beginning March 16, 2020.

Communication is important in science. This is an interesting way to improve communication skills.
03/10/2020

Communication is important in science. This is an interesting way to improve communication skills.

This is MS awareness week. Our lab is trying to help with research and exercise program for people with MS. https://ww...
03/09/2020
#ThisIsMS

This is MS awareness week. Our lab is trying to help with research and exercise program for people with MS.

https://www.nationalmssociety.org/msawarenessweek/stories?profile=Antonia&utm_source=MC&utm_medium=email&utm_campaign=FY20-News-MSAW1&utm_name=FY20-News-MSAW-Antonia&utm_content=s_src=news-fy20-email&utm_content=s_subsrc=MSAW-Antonia&utm_content=

Check out powerful stories of people with MS doing whatever it takes to move life forward and share to show the world. #ThisIsMS

I just gave a lecture to the Nutrition and Exercise Science Department at Florida State University. They are doing some...
03/05/2020

I just gave a lecture to the Nutrition and Exercise Science Department at Florida State University. They are doing some interesting research and they have a good group of graduate students.

At long last, Riley and Bethany's paper. https://journals.ke-i.org/mra/article/view/2049
02/27/2020
MUSCLE MITOCHONDRIAL CAPACITY AND ENDURANCE IN ADULTS WITH TYPE 1 DIABETES | Medical Research Archives

At long last, Riley and Bethany's paper.

https://journals.ke-i.org/mra/article/view/2049

MUSCLE MITOCHONDRIAL CAPACITY AND ENDURANCE IN ADULTS WITH TYPE 1 DIABETES Article Sidebar 13-Feb-2049.pdf Published Feb 21, 2020 DOI: https://doi.org/10.18103/mra.v8i2.2049 Main Article Content Riley A Hewgley University of Georgia Bethany T. Moore University of Georgia T. Bradley Willingham Univer...

A distinguished speaker (former UMich fellow grad student). Everyone is welcome, she will do a great job.
02/25/2020

A distinguished speaker (former UMich fellow grad student). Everyone is welcome, she will do a great job.

02/17/2020

Former Dawg Dr. Jen Trilk has a job in Greenville. Job posting for Masters graduates, looking for a Coordinator who has excellent organizational skills, can work effectively and compassionately with patients, and who has a teamwork personality!

http://uscjobs.sc.edu/postings/74125

The lab attending the SEACSM annual meeting in Jacksonville. just some random pictures. Overall it was a great time an...
02/16/2020

The lab attending the SEACSM annual meeting in Jacksonville. just some random pictures. Overall it was a great time and we left with new experimental ideas

The lab attending the SEACSM annual meeting in Jacksonville. just some random pictures. Overall it was a great time and we left with new experimental ideas

Congratulations to Max, Sam and Ellie! This paper is already viewed and downloaded more than 10% of the other articles ...
02/16/2020
Near Infrared Spectroscopy Measurements of Mitochondrial Capacity Using Partial Recovery Curves

Congratulations to Max, Sam and Ellie! This paper is already viewed and downloaded more than 10% of the other articles on Frontiers.

https://www.frontiersin.org/articles/10.3389/fphys.2020.00111/full

BackgroundNear-infrared spectroscopy (NIRS) has been used to measure muscle mitochondrial capacity (mVO2max) as the recovery rate constant of muscle metabolism after exercise. The current method requires as many as 50 short ischemic occlusions to generate two recovery rate constants.PurposeTo determ...

A photo on the wall in the conference room. This is Jarrod Calls research. Our lab needs to come up with some art for ...
02/12/2020

A photo on the wall in the conference room. This is Jarrod Calls research. Our lab needs to come up with some art for the walls, any thoughts?

Our lab in the news. Scroll down to The article on Infared Rxhttps://deansdiary.augusta.edu/
02/10/2020
Dean's Diary | MCG Dean's Diary & Insight & commentary from the Medical College of Georgia

Our lab in the news. Scroll down to The article on Infared Rx

https://deansdiary.augusta.edu/

February 7, 2020Dean's Diary - Medical College of GeorgiaHess, David Dear Medical College of Georgia Friends, New MCG video helps tell our story We just finished the MCG video that we do periodically and which I hope you will take a few minutes — six minutes and three seconds — to watch. Feel fr...

Birthday pictures, and a list of recent publications. Thanks to everyone for another enjoyable year!Hewgley, R.A., B.T....
01/30/2020

Birthday pictures, and a list of recent publications. Thanks to everyone for another enjoyable year!

Hewgley, R.A., B.T. Moore, T.B. Willingham, N.T. Jenkins, K.K. McCully. Muscle mitochondrial capacity and endurance in adults with Type 1 diabetes. Medical Research Archives [Accepted] 1/28/2020.

Sumner, M.D., S. Beard, E.K. Pryor, I. Das, K.K. McCully. Near infrared spectroscopy measurements of mitochondrial capacity using partial recovery curves. Frontiers of Physiology. [Accepted]. 1/30/2020.

McCully, K.K, Z. Liebowitz, M.D. Sumner, S. Beard. Mitochondrial capacity using NIRS and incomplete recovery curves: Proximal and Medial Vastus Lateralis muscle. SPIE [Submitted].

Ware, M.E..K.K. McCully, Yuri Feito. Benefits of Prescribing High-Intensity Interval Training Programs for Individuals with Down syndrome. ACSM Health and Fitness Journal. [Accepted 01/16/2020].

Ware, M.E.. and K.K. McCully. Chapter 11: Intellectual Disability and Down Syndrome. GETP18 ACSM. [Accepted], 2020

Address

330 River Road
Athens, GA
30602

The Orbit, East & West, and East Campus Express bus lines stop at Ramsey.

Opening Hours

Monday 08:00 - 17:00
Tuesday 08:00 - 17:00
Wednesday 08:00 - 17:00
Thursday 08:00 - 17:00
Friday 08:00 - 17:00

Telephone

(706) 542-1129

Website

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Videos

Emily's CURO presentation
Emily's CURO presentation

I just picked one slide, Emily did a great job of representing our lab!

Brad's talk at Chance Symposium
Brad's talk at Chance Symposium

Lab Alunmi Brad presenting his new research. The image is three muscle fibers and some red blood vessels. The Green is autoflourecing NADH. The NADH is in the mitochondria showing the shape and function of the mitochondria. Brad is measuring the rate of NADH production

Friday in the lab
Friday in the lab

We had a busy Friday afternoon in the lab. Lots of experiments with some very interesting results. (and the groups analyzing data aren't in this picture! How many people can you recognize?

Megan's defense audience
Megan's defense audience

Megan's masters defense See if you can spot our lab members in the audience. It was a great presentation.

Melissa's Ph.D., this is her introduction.

Lily's summer 2016 presentation
Lily's summer 2016 presentation

Listen carefully and you can hear part of Lily's Young Dawg presentation. She insisted on presenting in the dark, but did a great job.

The Noninvasive interest group meeting at ACSM in Boston. The lab showed off the 1016 t shirts, and Melissa won a research award. And we meet and talked science with new and old friends

Award ceremony
Award ceremony

Kelly Ann explaining her research. Nice clinical justification!

Award presentation
Award presentation

Becky explaining her research. Not bad considering she wasn't warned she needed to do that.

Ok, we need to improve our video skills. But the lab was busy today!

Today Callie presented her CURO poster to the College of Agriculture. And it seems, she was judged as part of a best poster contest. Not sure how that went, other than one judge said her data is publishable. :^)

Oxygen consumption during electrical stimulation: Brad's version!

Another good week in the lab, finished off with our first lab 'chalk talk'. Brad lead the discussion with some ideas about possible dissertation experiments. Hannah had a very positive meeting with doctors at the University Cancer and Blood Center. Melissa is solidifying her dissertation, and Brad & Michael are finishing up their 'foot in the air' experiments.

Not only was our lab busy, but the https://www.facebook.com/ExerciseVascularCellBiologyLaboratoryUga was testing as well!

Saturday morning and the lab is busy! Katie and Elise are testing three people. And we also discovered this link. :^) http://studentaffairs.uga.edu/

Another Friday in the lab. Next week is our lab celebration on Wednesday. Today we had Alia and Alyssa collecting data, Brice and Rebecca finishing their analysis, Zoe and Becki summarizing their data, and Jake and Darius reviewing data. Some interesting results overall. In terms of graduate students: the video if you can see it is Brad demonstrating the diving reflex using NIRS. Diving into ice water is not for the faint of heart.

The lab honoring our retiring department head.

Sarah walking across the stage to recieve her masters degree. A nice way to finish a great time in the lab.

Nick's defense. His experiments included mitochondrial capacity measurements in our lab.

Charles Tipton recieving the Hetherington Award for his lifelong contributions to Kinesiology. A well deserved honor.

This weeks winners of the Lab award: Terence and Michael for figuring out how to drive the air compressor from an external signal. On the way to a computerizing our rapid cuff inflation protocol. The clicking sound is the air compressor being turned on.

Another summer graduation movie. Jared and Melissa getting ready to walk across the stage. Thinking of what to say to President Adams?

Saturday August 4th, Jared Brizendine and Melissa Erickson recieve their Masters degrees. Well done!

Jared Brizendine at his Masters Defense. Using NIRS to measure muscle mitochondrial function in endurance trained people (or something like that).

Fatigued Leg Extension
Fatigued Leg Extension

This is an example of a fatigued right leg extension in one of our spinal cord injured subjects. He was put through an intense workout that day and couldn't wait to come back for the next!

Full Right Leg Extension
Full Right Leg Extension

This is a full right leg extension of one our spinal cord injured subjects through electric-stimulation training.

E-Stim Full Leg Extension
E-Stim Full Leg Extension

This is an example of a full leg extension during electric stimulation. If this is how your leg appears during training you may consider this an excellent contraction.

E-Stim Slight Fatigue Example
E-Stim Slight Fatigue Example

This video illustrates the pre-onset of fatigue, where your muscle if slightly fatigued. At this point you might consider only performing one more set or finishing the set if your last repetitions appear similar to the fatigue video.

E-Stim Fatigue Example
E-Stim Fatigue Example

This is an example of a fatigued leg extension during electric stimulation. If this is how your leg appears during training it is best to stop within a few repetitions.

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Ben from our department will be on the air! Check him out. Monday June 29th at 11:00am CST, Benjamin D. Boudreaux, M.S. will share his unique and personal insight on exercise for those with autism. Benjamin Boudreaux is a 3rd year PhD Kinesiology student at the University of Georgia. His research expertise consists of physical activity measurement, the use of consumer wearable technology devices, and the 24-hour activity cycle. Besides working in academia, Ben has previous clinical experience working in cardiology as an exercise specialist and working with different collegiate sport teams. During his free time, he enjoys exercising such as running, biking, swimming, and cooking different meals from his hometown of New Orleans. Regardless with all of Ben’s accomplishments, believe it or not he is diagnosed with a high form of Autism Spectrum Disorder. If you cannot watch live on Facebook (@ExerciseBuddyApp), be sure to subscribe to Coach Dave's YouTube Channel.
A new way to submitting research papers for publication. Feel free to look at Adeola's paper and make comments.