Exercise Biochemistry Lab - Londrina State University

Exercise Biochemistry Lab - Londrina State University This page is intended to disseminate information related to the Exercise Biochemistry Laboratory of

13/05/2020

NEW PUBLICATIONS (July/2019 to April/2020) 💡💡💡🤩



In the last months we had 5 papers published in international journals, coming from the results of master's and doctoral research projects mentored by Professor Rafael Deminice and conducted at . Check it out below:



🗞️ TITLE: Weekday and weekend physical activity and stationary behavior patterns of people living with HIV (in collaboration with researchers from Case Western Reserve University / USA)

- AUTHORS: Vitor Hugo Oliveira e collaborators

- JOURNAL: JANAC – Journal of the Association of Nurses in AIDS Care

- PURPOSE: To analyze differences regarding physical activity and stationary behavior patterns between weekdays and weekend days in a cohort of people living with HIV, and to determine whether demographic, physical, and behavioral variables moderated these differences.

- CONCLUSIONS: Physical activity and stationary behavior patterns of people living with HIV differ between weekdays and weekend days. When using accelerometry to measure activity patterns of this population, we suggest that validation parameters consider both weekdays and weekend days. Also, because of being less active on weekend days, interventions to promote physical activity could focus on these days.

- ACCESS LINK: https://www.ncbi.nlm.nih.gov/pubmed/31855872



🗞️ TITLE: Sarcopenia in people living with the Human Immunodeficiency Virus: a systematic review and meta-analysis

- AUTHORS: Vitor Hugo Oliveira, Nutricionista Ana Lucia Borsari and collaborators

- JOURNAL: European Journal of Clinical Nutrition

- PURPOSE: To establish the prevalence of sarcopenia among people living with HIV, to compare the prevalence of sarcopenia among people living with HIV and people without HIV, and to investigate predictors of sarcopenia among people living with HIV from the existing literature.

- CONCLUSIONS: We found a high prevalence of sarcopenia in people living with HIV (24.1%), with a significantly greater odds of sarcopenia among people living with HIV compared to controls of a similar age. Furthermore, this population had a higher prevalence of many risk factors associated with sarcopenia in the general population, in addition to risks posed with many HIV-related factors.

- ACCESS LINK: https://www.ncbi.nlm.nih.gov/pubmed/32341489



🗞️ TITLE: Effects of a Combined Exercise Training Program on Health Indicators and Quality of Life of People Living with HIV: A Randomized Clinical Trial

- AUTHORS: Vitor Hugo Oliveira and collaborators

- JOURNAL: AIDS and Behavior

- PURPOSE: To conduct a randomized clinical trial to evaluate the effect of 16 weeks of combined exercise training on muscle strength, body composition, depression, anxiety, and quality of life of people living with HIV.

- CONCLUSIONS: Sixteen weeks of combined exercise training increased muscle strength, and improved depression and quality of life indexes in a small sample of people living with HIV, showing its potential to ameliorate important disturbances experienced by this population. Also, combined exercise training appears to be an engaging exercise model for people living with HIV, since it combines strength and aerobic exercises in same training session, generating physiological adaptations from these two types of exercise. Thus, combined exercise training is a safe and an effective complementary intervention for the health promotion of this population.

- ACCESS LINK: https://www.ncbi.nlm.nih.gov/pubmed/31552510



🗞️ TITLE: Moderate vs high-load resistance training on muscular adaptations in rats

- AUTHORS: Camila Padilha, Paola Cella and collaborators

- JOURNAL: Life Sciences

- PURPOSE: To investigate the moderate versus high-load resistance training on muscle strength, hypertrophy and protein synthesis signaling in rats.

- CONCLUSIONS: Both high-load and moderate-load training induce muscle hypertrophy and strength increases in a similar way. Moderate-load training seems to favor slow fiber hypertrophy due to higher training volume.

- ACCESS LINK: https://www.ncbi.nlm.nih.gov/pubmed/31639398



🗞️ TITLE: Creatine supplementation exacerbates ethanol-induced hepatic damage in mice

- AUTHORS: Poliana Marinello, Paola Cella and collaborators

- JOURNAL: Nutrition

- PURPOSE: To investigate the effects of creatine supplementation on early stages of ethanol-induced hepatic damage.

- CONCLUSIONS: Creatine supplementation associated with ethanol is able to interfere in the alcohol metabolism and oxidative stress and to exacerbate ethanol-induced hepatic damage. These new findings are opposite to those observed in several studies where protective effects of creatine in a wide variety of injury models, including non-alcoholic fatty liver disease, were described.

- ACCESS LINK: https://www.ncbi.nlm.nih.gov/pubmed/31265967



BENEFITS OF PHYSICAL EXERCISE FOR PEOPLE LIVING WITH HIVAlthough the drugs used to treat HIV (antiretroviral therapy) ha...
02/05/2020

BENEFITS OF PHYSICAL EXERCISE FOR PEOPLE LIVING WITH HIV
Although the drugs used to treat HIV (antiretroviral therapy) have improved the quality of life and increased the life expectancy of people living with HIV, these individuals still have a greater incidence of chronic diseases (such as hypertension, cardiovascular diseases, osteoporosis, among others) and greater loss of muscle strength and muscle mass when compared to people without HIV. Thus, physical exercise appears as an alternative therapy to be used together with antiretroviral therapy, to alleviate these symptoms and improve the quality of life.
Considering that, LABEX conducted a research project aiming to investigate the effects of 16 weeks of combined training (resistance exercise + aerobic exercise) on different health indicators of people living with HIV. The project was coordinated by Dr. Rafael Deminice and was a part of Dr. Vitor Hugo Oliveira graduate research.
The results of this project have been published in two journals: AIDS and Behavior and Applied Physiology, Nutrition, and Metabolism. Despite the relatively project short duration, we observed improvements in muscle strength, depression rates, quality of life, oxidative stress and homocysteine concentration, demonstrating the potential effects of combined exercise training to improve important metabolic disorders experienced by people living with HIV.
You can check the full papers on the links below:
- Link: https://www.nrcresearchpress.com/doi/abs/10.1139/apnm-2018-0734?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=apnm
- Link: https://link.springer.com/article/10.1007/s10461-019-02678-3
Acknowledgments: Labex thanks everyone who collaborated during this project, including patients, medical team responsible for the HIV/AIDS outpatient clinics and other professors and graduate students involved.

27/04/2019

NEW PUBLICATIONS 💡💡💡🤩
2019 is just starting, but the publications are in full production. This year we already had 4 articles published in international journals, as a result of masters and doctoral projects mentored by Professor Rafael Deminice. Check below:
🗞️ TITLE: Homocysteine-lowering exercise effect is greater in hyperhomocysteinemic people living with HIV: A randomized clinical trial
- AUTHORS: Vitor Oliveira and collaborators
- JOURNAL: Applied Physiology, Nutrition, and Metabolism
- PURPOSE: To describe blood homocysteine and oxidative stress markers in PLHIV and those without HIV infection, and to examine the effects of a 16-week combined training exercise program (CTE) on oxidative stress and homocysteine concentrations of PLHIV
- CONCLUSIONS: sixteen weeks of CTE was able to decrease elevated homocysteine concentration and enhance redox balance of PLHIV with hyperhomocysteinemia, which could improve their cardiovascular risk.
- ACCESS LINK: https://www.ncbi.nlm.nih.gov/pubmed/30861351
🗞️ TITLE: Creatine supplementation in Walker-256 tumor-bearing rats prevents skeletal muscle atrophy by attenuating systemic inflammation and protein degradation signaling
- AUTHORS: Paola Cellalla and collaborators
- JOURNAL: European Journal of Nutrition
- PURPOSE: To investigate the effects of creatine supplementation on muscle wasting in Walker-256 tumor-bearing rats.
- CONCLUSIONS: Creatine supplementation prevents skeletal muscle atrophy by attenuating tumor-induced pro-inflammatory environment, a condition that minimizes Atrogin-1 and MuRF-1-dependent proteolysis.
- ACCESS LINK: https://www.ncbi.nlm.nih.gov/pubmed/30806774
🗞️ TITLE: Antioxidant vitamin supplementation prevents oxidative stress but does not enhance performance in young football athletes.
- AUTHORS: Doni Oliveira and collaborators
- JOURNAL: Nutrition
- PURPOSE: to verify the effects of supplementation with antioxidants (vitamins C and E) on oxidative stress, delayed-onset muscle soreness (DOMS), and performance in football players during a recovery period after an exercise-induced oxidative stress protocol.
- CONCLUSIONS: Antioxidant supplementation does not attenuate elevated markers of muscle damage or muscle soreness promoted by acute exercise and do not exert any ergogenic effect on football performance of young athletes, although it reduced oxidative stress.
- ACCESS LINK: https://www.ncbi.nlm.nih.gov/pubmed/30927644
🗞️ TITLE: Resistance exercise counteracts tumor growth in two carcinoma rodent models
- AUTHORS: Camila Padilha and collaborators
- JOURNAL: Medicine & Science in Sports & Exercise
- PURPOSE: Two solid adenocarcinoma models (Walker-256 and Ehrlich) were used to investigate the effects of RE on tumor cell proliferation, growth and aggressiveness parameters tumor-bearing animals' lifespan.
- CONCLUSIONS: RE may mitigated tumor growth and tumor malignancy parameters such as lower histopathological grade, assuming less nuclear pleomorphism and mitotic cells, smaller viable tumor area and decreased tumor cell proliferation in both adenocarcinomas. In addition, RE induced tumor vascularization.
- ACCESS LINK: https://www.ncbi.nlm.nih.gov/pubmed/30985506

Exercise Biochemistry Lab of Londrina State University conducts research on sarcopenia in people living with HIV Dur...
01/08/2018

Exercise Biochemistry Lab of Londrina State University conducts research on sarcopenia in people living with HIV
During the year of 2018, our lab is conducting a research on Sarcopenia Syndrome in people living with HIV. Sarcopenia is a syndrome characterized by progressive and generalized loss of muscle mass and strength, and it presents great clinical relevance, since it leads to the development of adverse effects, such as physical inactivity, poor quality of life and death. Sarcopenia has a high prevalence among the elderly, because of the increased life expectancy of the population, but it also affects people with chronic diseases such as diabetics, chronic kidney disease patients on hemodialysis and people living with HIV. The premature diagnosis and treatment of Sarcopenia can help to improve patients' quality of life.
This research is part of the work conducted by Vitor Hugo Oliveira, PhD. student in Exercise Physiology from Londrina State University, which has the purpose of determining the prevalence of Sarcopenia in people living with HIV, as well as to identify the main factors that contribute to the development of Sarcopenia in this population.
Initially, more than 230 patients were assessed during the months of April, May and June of 2018, using the bioelectric impedance method to determine body composition, as well as handgrip strength measures and a battery of physical function tests. In the next stage of the study, patients should be assessed using more specific tests, involving the use of X-ray dual-density densitometry (DEXA) method to evaluate body composition, an isokinetic dynamometer to measure muscle strength, electromyography, accelerometry, nutritional assessment, among other tests and evaluations.
As preliminary results, 44.2% of the patients had pre-sarcopenia (low muscle mass) or sarcopenia (low levels of muscle mass, strength and physical function). In addition, it appears that men, subjects with normal weight or malnourished, and smokers present a greater risk of developing Sarcopenia. These results are being prepared to be presented during the 8th Brazilian Congress on HIV-AIDS and Related Viruses, which will be held in September.
To know more
• Information about sarcopenia: https://www.medicalnewstoday.com/articles/318501.php
• Paper about low levels of muscle strength in people living with HIV: https://www.ncbi.nlm.nih.gov/pubmed/28327461

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