Physiology Now

18/09/2023

Conhece o ?
Venha para o instagram e tenha conteúdo sobre Fisiologia.

22/08/2023

09/12/2021

➡️ Obesity is a complex disease caused by an excessive amount of body fat. Obesity is a medical problem and represents an important risk factor for the development of serious diseases such as insulin resistance, type 2 diabetes, cardiovascular disease, and some types of cancer.

➡️ Not to be overlooked are the psychological issues that, in obese subjects, turn into very serious pathologies, such as depression, phobias, anxiety, and lack of self-esteem. In addition to modifying one's lifestyle, the reduction of body mass can be promoted by different natural compounds such as essential oils (EOs).

➡️ EOs are mixtures of aromatic substances produced by many plants, particularly in medicinal and aromatic ones. They are odorous and volatile and contain a mixture of terpenes, alcohols, aldehydes, ketones, and esters. Thanks to the characteristics of the various chemical components present in them, EOs are used in the food, cosmetic, and pharmaceutical fields. Indeed, it has been shown that EOs possess great antibiotic, anti-inflammatory, and antitumor powers.

➡️ Emerging results also demonstrate the anti-obesity effects of EOs. We have examined the main data obtained in experimental studies and, in this review, we summarize the effect of EOs in obesity and obesity-related metabolic diseases.
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Referência: De Blasio A, D'Anneo A, Lauricella M, Emanuele S, Giuliano M, Pratelli G, Calvaruso G, Carlisi D. The Beneficial Effects of Essential Oils in Anti-Obesity Treatment. Int J Mol Sci. 2021 Oct 31;22(21):11832. doi: 10.3390/ijms222111832. PMID: 34769261; PMCID: PMC8584325.

04/12/2021

03/12/2021

➡️ Congenital insensitivity to pain (CIP) is caused by extremely rare Mendelian genetic disorders. CIP individuals demonstrate the unexpectedly severe consequences of painlessness.

➡️ Although only a small number of causative conditions and genes are known, most have led to profound insights into human nociception.

➡️ CIP gene discovery is catalyzing the manufacture of completely new classes of analgesics, and these are needed as alternatives to synthetic highly potent opioids.
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Referência: Drissi I, Woods WA, Woods CG. Understanding the genetic basis of congenital insensitivity to pain. Br Med Bull. 2020 May 15;133(1):65-78. doi: 10.1093/bmb/ldaa003. PMID: 32219415; PMCID: PMC7227775.

02/12/2021

In recent decades, both clinical and animal studies have shown that fetal growth restriction (FGR), caused by exposure to adverse uterine environments, is a risk factor for hypertension as well as for a variety of adult diseases.

This observation has shaped and informed the now widely accepted theory of developmental origins of health and disease (DOHaD). There is a plethora of evidence supporting the association of FGR with increased risk of adult hypertension; however, the underlying mechanisms responsible for this correlation remain unclear.

This review aims to explain the current advances in the field of fetal programming of hypertension and a brief narration of the underlying mechanisms that may link FGR to increased risk of adult hypertension. We explain the theory of DOHaD and then provide evidence from both clinical and basic science research which support the theory of fetal programming of adult hypertension. In addition, we have explored the underlying mechanisms that may link FGR to an increased risk of adult hypertension.
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Referência: Bhunu B, Riccio I, Intapad S. Insights into the Mechanisms of Fetal Growth Restriction-Induced Programming of Hypertension. Integr Blood Press Control. 2021 Oct 9;14:141-152. doi: 10.2147/IBPC.S312868. PMID: 34675650; PMCID: PMC8517636.

02/06/2021

👉 Hipócrates, o pai da medicina, já dizia “descanse assim que houver dor” 😴😴😴

☑ Pesquisadores Canadense criaram um modelo experimental, onde eles manipulam o sistema circadiano de camundongos por meio de uma exposição adicional de luz ao final da fase clara, permitindo um repouso de 4 horas a mais todos os dias. Vale ressaltar que roedores são animais noturnos, e o repouso para estes animais é sob a luz.

☑ Em seguida eles testaram o efeito do “repouso adicional” sobre a hipertrofia cardíaca (coarctação da aorta) ou Infarto do Miocárdio (ligadura da coronária desc. anterior).

☑ Foi observado que os animais coarctados e submetidos ao repouso adicional (TAC+rest) desenvolveram menor hipertrofia cardíaca com menos remodelamento cardíaco adverso e manteve uma melhor função cardíaca observada pelo ecocardiograma ao longo de 4 semanas.

☑ Nos animais infartados e submetidos ao repouso adicional (MI+rest) observou-se menor dilatação do ventrículo esquerdo, e melhor função cardíaca por 8 semanas após a indução do infarto quando comparados aos respectivos controles.

☑ Os autores também demonstraram que o “repouso adicional” todas as manhãs promoveu maior atividade da “actomiosina MgATPase” miocárdica, o que está associado a uma melhor preservação da função contrátil do músculo ao nível dos sarcômeros cardíacos.

☑ Buscando uma relação translacional para o modelo, os autores também demonstraram que 91 genes cardíacos estão >1,3 vezes expressos nos corações dos animais com repouso adicional em comparação aos controles. Além disso, grande parte destes genes apresentam ritmos circadianos de expressão e são alvos de ação terapêuticas dos principais medicamentos utilizados nas patologias cardíacas.

☑ Em conclusão, o repouso adicional todas as manhãs melhora a função cardíaca de corações acometidos por patologias, e a associação de repouso mais terapia convencional poderia aumentar a eficácia ao tratamento.

Texto: .danielr / Academic-editor of .
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Referência: Tami Martino, Cristine Reitz, Faisal Alibhai et al. Rest Profoundly Protects Against Cardiac Remodeling and Benefits Repair, 29 March 2021.

13/05/2021

Physiology Now

10/05/2021

❤ Mitocôndria ❤

06/05/2021

🤔 Será uma coincidência❓ O eixo elétrico cardíaco apontando para o ❓ ❤❤❤😊