Cox Systems Biology Group

Cox Systems Biology Group The aim of the Cox Systems Biology Lab research group is to apply a diverse interdisciplinary approach to the study of reproductive biology and development.

Our research is largely focused on placenta biology and pathology. We work with stem cell-based models as well as mouse and human tissue. We use cell labelling and sorting to identify novel populations of cells and changes in their dynamics in development and disease. We apply high-throughput techniques such as mass spectrometry based proteomics, microarray transcriptional profiling, trangenesis (

genetic manipulation of cells) and computational biology to model the dynamics of gene expression and regulation.

Shocking disparities in reproductive research. A Poor Research Landscape Hinders the Progression of Knowledge and Treatm...
11/21/2021

Shocking disparities in reproductive research. A Poor Research Landscape Hinders the Progression of Knowledge and Treatment of Reproductive Diseases https://www.biorxiv.org/content/10.1101/2021.11.16.468787v1

Reproductive diseases have gone under the radar for many years, resulting in insufficient diagnostics and treatments. Infertility rates are rising, preeclampsia claims over 70 000 maternal and 500 000 neonatal lives globally per year, and endometriosis affects 10% of all reproductive-aged women but....

I found this disturbing. If this is true, I am shocked.
07/16/2019

I found this disturbing. If this is true, I am shocked.

Do not let the Thirty Meter Telescope begin (with the military at your side)

07/04/2019

New publication from Katie with David our favorite pathologist.

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Here is a runaway feed forward system. The more you have the more you attract.
07/04/2019

Here is a runaway feed forward system. The more you have the more you attract.

The NIH is the federal steward of biomedical research in the United States. Taxpayers fund the NIH; the NIH supports research into the underlying biology, etiology, and treatment of diseases; and benefits of that research are returned to taxpayers. This is a large and complex enterprise, but at its....

Women advancing medical research
06/18/2019

Women advancing medical research

Today, vaccinating against cervical cancer is routine. But before Sarah Stewart, scientists dismissed the idea of a cancer-preventing vaccine as ludicrous

I suspect this is really just the tip of the iceberg of women who deserved recognition or had their work stolen by men.
06/16/2019

I suspect this is really just the tip of the iceberg of women who deserved recognition or had their work stolen by men.

The history of science has often seen women’s work overlooked and their credit stolen

Out now! I was on the advisory panel for three years during the tool's development. A great resource and platform for da...
04/09/2019

Out now! I was on the advisory panel for three years during the tool's development. A great resource and platform for data analysis of placenta literature, including images and gene expression data.

The placenta is one of the least understood, yet arguably one of the most important organs for human health and development. While there have been num…

Save the date for the Southern Ontario Reproductive Biology Meeting!
03/07/2019

Save the date for the Southern Ontario Reproductive Biology Meeting!

Local press coverage of our diabetes researchhttps://medicine.utoronto.ca/news/building-better-diabetes-predictor.
02/22/2019

Local press coverage of our diabetes research
https://medicine.utoronto.ca/news/building-better-diabetes-predictor.

Every year in Canada as many as 20 per cent of pregnant women develop gestational diabetes mellitus (GDM), which in most cases is a temporary form of diabetes. Even though the condition usually goes away following delivery of their babies, women who’ve had this transient form of diabetes are about...

Here is an excellent podcast of some real and practical way to change our granting system given low levels of funding.
02/19/2019

Here is an excellent podcast of some real and practical way to change our granting system given low levels of funding.

Many grant funding decisions are random, with luck playing a large part. How can the system be improved, particularly when funds are tight? 

New collaborative publication with Wheeler lab on gestational diabetes. Great job Saifur!https://rdcu.be/bg72E
01/16/2019

New collaborative publication with Wheeler lab on gestational diabetes. Great job Saifur!
https://rdcu.be/bg72E

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