Tanentzapf Lab

Tanentzapf Lab We are a scientific research lab located in the life science institute at the university of british columbia.

The Tanentzapf lab uses molecular biology, genetics, and cutting edge imaging technology to address basic biological questions. In the Tanentzapf lab we use Drosophila (fruit fly) as our genetic model organism of choice.

01/05/2017

Last month our paper on the role of integrin-based adhesion in regulation force transmission in epithelial tissues was published in Developmental Cell!

Goodwin, Ellis et al. identify integrin-containing focal adhesion-like structures on the basal amnioserosa surface that act as tethers, anchoring the apical cell surface to the substrate. These basal adhesions are required for dorsal closure, where they modulate apical surface force transmission and...

01/05/2017

Haven't updated for a while but back in September our paper was featured on the cover of current biology!

Adult stem cell niches must remain a consistent size to maintain optimal numbers of stem cells. Fairchild et al. find a novel role for occluding junctions in maintaining homeostasis of the fly te**is stem cell niche. Disruption of these junctions in the differentiating somatic cells leads to growth…

Our lab's latest paper is featured on the cover of the latest issue of the journal Development!
08/04/2015

Our lab's latest paper is featured on the cover of the latest issue of the journal Development!

Cover: Whole-mount adult Drosophila ovaries. The gap junction protein Zero population growth (Zpg/Innexin4) tagged with GFP (green) labels the developing germ line throughout oogenesis. DAPI counterstaining labels the nuclei (magenta). See Research article by Smendziuk et al. on p. 2598.

Our latest paper is available online at Development. Paper should come out shortly!
07/15/2015

Our latest paper is available online at Development. Paper should come out shortly!

Development. 2015 Jun 26. pii: dev.123448. [Epub ahead of print]

Our latest paper is now out as Development!
03/18/2015

Our latest paper is now out as Development!

Interactions between the soma and germline are essential for gametogenesis. In the Drosophila te**is, differentiating germ cells are encapsulated by two somatic cells that surround the germline throughout spermatogenesis. chickadee (chic), the fly ortholog of Profilin, mediates soma-germline interac…

03/18/2015

Author Summary Cells are the building blocks of our bodies. How do cells rearrange to form three-dimensional body plans and maintain specific tissue structures? Specialized adhesion molecules on the cell surface mediate attachment between cells and their surrounding environment to hold tissues toget…

03/18/2015

Scientific Data, Published online: 11 March 2014; | doi:10.1038/sdata.2014.2

03/18/2015

Animal muscles must maintain their function while bearing substantial mechanical loads. How muscles withstand persistent mechanical strain is presently not well understood. The basic unit of muscle is the sarcomere, which is primarily composed of cytoskeletal proteins. We hypothesized that cytoskele…

03/18/2015

Disruption of a Conserved Autoinhibitory Intramolecular Interaction between the Talin FERM and the Talin Rod Leads to Morphogenetic Defects, Including Delayed Dorsal Closure

03/18/2015
03/18/2015
03/18/2015

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