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Klein Lab - Equine Reproduction Research and More

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Klein Lab - Equine Reproduction Research and More

Welcome to the Klein Lab. Our research revolves around the Physiology of Early Pregnancy in the Horse.

Dr. Claudia Klein originally hails from Germany where she obtained her veterinary degree. Following a year in research and a year as Clinical Instructor, she relocated to Gainesville, Florida, US in 2006 to pursue a residency in Equine Reproduction. In 2008 Dr. Klein moved to Lexington, KY to pursue a PhD on Early Equine Pregnancy in the mare. In late 2012 she joined the College of Veterinary Medicine at the University of Calgary as Assistant Professor of Theriogenology.

17/05/2026

Definitely worth watching. 🐎 🎥

18/04/2026

The waiting game of peer review…. Finding reviewers….

14/04/2026

Katerina defended her PhD work today. The decoration of the doctoral hat reflects the main topic of her work: physiology of boar s***m. 🐷 🐽 🐖

10/04/2026

Equine endometrial fibrosis is an interesting topic……. We recently looked at the role of MFGE8 using single cell sequencing and in situ hybridization.

“Milk fat globule EGF and factor V/VIII domain containing (MFGE) as a novel player in equine endometrial fibrosis” 🐎

21/11/2025

In vitro production of bovine embryos still has its limitations, such as low blastocyst rate and lower embryo quality, resulting in lower pregnancy rates following transfer compared to in vivo produced embryos. Transcriptional studies comparing both types of embryos mainly utilize oocytes retrieved from slaughterhouse material for IVP, thereby introducing the possibility, that differences between IVP and in vivo embryos are in part attributable to differing sources of oocytes.

The present study compared the proteome of oocytes retrieved from slaughterhouse material, with and without a period of in vitro maturation, and in vivo matured oocytes obtained from superovulated donor cattle.

Main finding: In vitro matured oocytes were characterized by an overall enhanced translational activity affecting mainly proteins involved in energy metabolism, transcription and translation, and oocyte activation. Deregulation of the proteome in in vitro matured oocytes likely negatively affects subsequent developmental events.

13/11/2025

Artistic imaging. 🔬 🧬 👩‍🔬

07/11/2025

We conducted a meta-analysis of transcriptome data from Day 7-8 in vivo and in vitro produced bovine blastocysts by subjecting raw data to a standardized analysis to gain a more robust understanding about gene expression patterns during in vitro embryo development. Most notably, energy metabolism was yet again confirmed as altered in in vitro produced (IVP) embryos. Hence, energy metabolism in IVP embryos is a suitable parameter for assessing the effects of in vitro fertilization on development and should be used as a key marker to evaluate assisted reproductive protocols for improving whole animal outcomes.

01/11/2025

In situ hybridization of the bovine oviduct targeting a marker of secretory cells (green) and ciliated cells (yellow and red). 🐄 🐮

26/05/2025

Elena evaluated the effect of substrate stiffness on the gene expression of equine endometrial fibroblasts. To sum it up: think twice before using conventional tissue culture plastic. 🧬 🐴 👨‍🎓

04/04/2025

Busy week. Elena successfully defended her PhD work on equine endometrial fibrosis. 🐴 👨‍🎓 🥳

31/03/2025

Gregor successfully defended his PhD today. In Germany it’s a tradition that fellow PhD students craft a PhD hat. 👨‍🎓

Adresse

Mariensee

Webseite

http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/50542854/?sort=date&direction=ascending

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