Parallel gpat discussion center

10/09/2022

10/09/2022

Medicinal Chemistry MCQ’s

1. Amino acids are joined together via which bond?
a. Dipole-Dipole
b. Amide
c. Hydrogen
d. Ionic

2. Amide Bond Resonance (ABR) in terms of protein structure is an important feature. The N’s lone pair is delocalised, having several important ramifications. Select which of these is NOT a ramification.

a. O has a δ- charge and the N has a δ+; the Amide groups can form hydrogen bonds with each other.
b. Amide C-N bond has partial double bonds character, therefore backbone of protein ismore rigid.
c. The orientation of atoms –CC(=O)NHC are all in a plane, the cis orientation is more stable than the trans.
d. The orientation of atoms –CC(=O)NHC are all in a plane, the trans orientation is morestable than the cis.

3. Hydrogen bonding is an essential bond type for the backbone of proteins. Which fact about hydrogen bonding is FALSE?

a. Forms H δ+ with X δ- (X = N,O, S)
b. Much weaker than chemical bonds
c. Vital for controlling the shape of a protein.
d. Amide bonds aren’t good at forming hydrogen bonds

4. The amino acid has little to no influence on protein structure:
a. Gly, G
b. Val, V
c. Asp, D
d. Pro, P

16/02/2021

Lubricant Excipients

Compression lubricants prevent adherence of granule/powder to punch die/faces and promote smooth ejection from the die after compaction. Lubricants can also be used when compression isn’t involved such as in powder blends for filling into capsules to prevent adherence of granule/powder to equipment surfaces and dosator mechanisms and coating the surface of multi-particulate dosage forms to inhibit agglomeration of individual particles. Minerals such as talc or silica, and fats, e.g. vegetable stearin, magnesium stearate or stearic acid are the most frequently used lubricants in tablets or hard gelatin capsules. The most widely used lubricants in use today are hydrophobic lubricants. These are usually effective at relatively low concentrations and many also have both anti-adherent and glidant properties

16/02/2021

Tannins are found commonly in the bark of trees, wood, leaves, buds, stems, fruits, seeds, roots, and plant galls. In all of these plant structures, tannins help to protect the individual plant species. Tannins that become stored in the bark of trees protect the tree from being infected by bacteria or fungi.

15/02/2021

Catharanthus roseus is an evergreen, herbaceous plant that belongs to the family of Apocynaceae and grown mostly for its alkaloids. C. roseus is commonly known as rosy periwinkle, Vinca Rosea, Cape periwinkle, the Madagascar periwinkle, Kemuning cina, nayantara, vinca-de-madagáscar, vinca del Cabo, rose periwinkle, vinca rosa, tapak dara in Indonesian, vinca rosada, sadaphuli in Marathi, shameless maria (maria-sem-vergonha), roseous vinca in Spanish, Dhafnaki in Greece and İzmir Güzeli in Turkish.

17/12/2020

10.Carbohydrates are precursors for many ____ compound
a. Organic b. Inorganic c. both a & b d. none
11.Monosaccharides is based on which of the following functional group
a. Phenol b. Alcohol c. Ketoses d. None
12. The carbohydratet hat is taken as a reference for writing the
configuration of others
a. Dihydroxyacetone b.Glyceraldehyde
c. D-Erythrose d. D-Xylose
13. lf two monosaccharide differ in configuration around a single carbon
atom, they are known as
a. Diclomers b. Bimers c. Epimers d. None
14. The non-carbohydrate moiety found in glycosides is known as
a. Aglycone b. Agnine c. both a & b d. None
15. Citrate Synthase is inhibited by ___________.
a. ATP b. Acetyl CoA c. ADH d. Both a & b
16. Kreb Cycle is ___________ in nature.
a. Anabolic b. Catabolic c. Amphibolic d. None
17. TCA cycle is actively involved in___________.
a. Gluconeogenesis b. Phosphorylation
c. Both a & b d. None
18. One of the following enzymes in glycolysis catalyzes an irreversible action.
a. Hexokinase b. Phosphofructokinase
c. Pyruvate kinase d. All of them

17/12/2020

1. Which of following is common compound shared by TCA cycle and Urea
Cycle.
a. α – Ketoglutarate b. Succinyl COA
c. Oxaloacetate d. Fumarate
2. There are about ________ types of specialized cells in Human body.
a. 250 b. 350 c. 450 d. 550
3. A eukaryotic cell is generally 10 to _________ um in diameter.
a. 400 b. 300 c. 200 d. 100
4. Sub-cellular organelles are _________ in prokaryotic cell.
a. present b. absent c. both a & b d. none
5. _________ is the largest cellular organelle in cell.
a. Golgi apparatus b. Lysosomes
c. Nucleus d. Mitochondria
6. __________ is the major site for purine nucleotide synthesis.
a. Brain b. Liver C. adipose Tissue d. Kidney
7. Nucleus contains ___________ the repository of genetic information.
a. Ribosome b. DNA c. Cytosol d. Vacuole
8. The cellular matrix is collectively referred to as _________.
a. Ribosome b. DNA c. Cytosol d. Vacuole
9. _________ is the programmed cell death or cell su***de.
a. Apoptosis b. Autotosis c. Destrosis d. None

27/09/2020

1:Anti Histamine = Use in Allergy
2:Analgesic = Pain Killer
3:Anti Pyretic = Fever
4:Anti Septic = Pus
5:Anti Biotic = Infection
6:Anti Anaemia = Low blood
7: Anti Emetic = Vomting
8:Anti Acid = Stomach Burn
9:Anti Flantulents = Gases
10:Anti Spasmodic = Abdominal pain
11:Anti Anginal = Cardiac pain
12:Anti Arhthnic = Cardiac Activity
13:Ant Hypertensive = BP
14:Anti Lipemic = Chlosterol+Lipids
15:Anti Coagulant = Norrowing of Blood
16:Anti Depressant = Depression
17:HYPONOTIC = For Sleep
18:Anti Psychotic = For Psychosis
19:Anti Anxiety = For Anxiety
20:Anti Parkinson = For Parkinson's
21:Anti Stroke = For Stroke
22:Anti Viral = Against Virus
23:Anti T.B = Against T.B
24:Anti Fungal = Against Fungus
25:Anti Bacterials = Against Bacteria
26:Anti Malaria = Against Malaria
27:Anti Inflamatory = Against Swelling.
28: Bronchodilators = For Respiration
29:Haemostatics = Collecting of Blood