16/03/2022
NEW PUBLICATION
Title:
Prepartum measurement of serum biomarkers reflecting osteoclastic and osteoblastic bone metabolism for predicting the risk of milk fever in dairy cows
Outline:
- Because bone homoeostasis depends on osteoblast–osteoclast interactions, we hypothesised that synchronous evaluation of serum biomarkers reflecting osteoblastic and osteoclastic bone metabolism before parturition would be useful for predicting the risk of milk fever (MF).
- A total of 58 late-pregnant cattle were assigned to four groups: nulliparous, primiparous, multiparous in the 2nd lactation and multiparous in the 3rd–5th lactation. The multiparous cows were further assigned to MF and non-MF groups according to the onset of MF.
- During the 2–3 weeks prepartum, serum ALP3 activity and the ALP3/TRAP5b ratio had moderate associations with the serum Ca concentration at day 0 (day of calving) in the multiparous cows, and receiver operating characteristic curve analysis revealed that ALP3 activity had excellent ability to pre- dict MF.
- In conclusion, prepartum serum ALP3 activity is a promising biomarker to predict MF in multiparous cows.
*If you are interested in this article, please feel free to contact me (via ReseachGate).
URL: https://doi.org/10.1017/S0022029922000218
(NY)
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この論文では、アルカリフォスファターゼの骨分画(ALP3)が、経産牛の代表的な分娩後疾患である乳熱(分娩後低カルシウム血症)発症の事前予測(分娩前3〜2週)に有望な血中バイオマーカーであることを明らかにしました。
今後、妊娠末期の乳牛の血中ALP3の動態や性状を分析することで乳熱の病態を解明し、分娩乳牛の健康を守る技術の開発に貢献します。
(NY)
Prepartum measurement of serum biomarkers reflecting osteoclastic and osteoblastic bone metabolism for predicting the risk of milk fever in dairy cows