17/02/2025
We are thrilled to share our latest research published in Nature Communications: "Digital aberration correction for enhanced thick tissue imaging exploiting aberration matrix and tilt-tilt correlation from the optical memory effect"
https://www.nature.com/articles/s41467-025-56865-z
🔍 Why is this important?
Optical aberrations are a major challenge in biological imaging, often degrading image quality in cell biology and histopathology diagnostics. Conventional adaptive optics methods struggle with thick tissue imaging, limiting their applicability in biomedical research.
✨ Our breakthrough?
We introduce a computational adaptive optics (CAO) approach that leverages the tilt-tilt correlation from the optical memory effect to digitally correct aberrations in thick biological tissues. This allows for:
✅ Enhanced imaging of human tissues under severe aberrations
✅ Robust performance against sample movement
✅ High-resolution imaging without the need for guide stars or wavefront sensors
🔬 Experimental Validation
Using a transmission-mode holotomography setup, we successfully demonstrated the effectiveness of our method, enabling clearer, more accurate imaging of thick tissues.
🎯 Impact
Our approach paves the way for advanced histopathological imaging, improving diagnostics and biomedical research applications!
Optical aberrations can hinder the quality of imaging outputs, affecting research across many disciplines. Here, using the tilt-tilt correlation from the optical memory effect, the authors are able to correct aberrations in challenging conditions, including highly aberrated or moving samples.
