Society of Biochemistry

Society of Biochemistry The official page of the Society of Biochemistry of the University of Kelaniya.

இயற்கைத் தாயையும் உழவின் மகிமையையும் கொண்டாடும் நாள்!Celebrating harvest, tradition, and togetherness.Wishing you a joyf...
14/01/2026

இயற்கைத் தாயையும் உழவின் மகிமையையும் கொண்டாடும் நாள்!

Celebrating harvest, tradition, and togetherness.

Wishing you a joyful and blessed Pongal!

🌕🪔 *උතුම් දුරුතු පුන් පොහෝ දිනය අදයි…!*🪔🌕සම්මා සම්බුදු රජාණන් වහන්සේගේ අසිරිමත් බුද්ධ ශාසනය ශ්‍රී ලංකා දේශයට පත් වූ ඉතිහ...
03/01/2026

🌕🪔 *උතුම් දුරුතු පුන් පොහෝ දිනය අදයි…!*🪔🌕

සම්මා සම්බුදු රජාණන් වහන්සේගේ අසිරිමත් බුද්ධ ශාසනය ශ්‍රී ලංකා දේශයට පත් වූ ඉතිහාසයේ අතිශයම පූජනීය වැදගත්කමක් උසුලන දිනයක් ලෙස *දුරුතු පුන් පොහෝ දිනය* අප බෞද්ධ ජනතාවගේ සිත් තුළ පවතී.

බුදුරජාණන් වහන්සේගේ ප්‍රථම ශ්‍රී ලංකාගමනය සිදු වූ මෙම පින්බර දිනයේදී, යක්ෂ නාග ආදී විවිධ ජන කොට්ඨාස අතර පැවති අවිවාද සමථයට පත් කරමින්, කරුණාවෙන්, මෛත්‍රීයෙන් හා ප්‍රඥාවෙන් යුත් ධර්මදේශනාවකින් දේශය සන්සුන් කළ අයුරු අපගේ ආගමික ඉතිහාසයේ අතිශයම උතුම් මොහොතක් ලෙස සටහන් වී ඇත.

මෙම උතුම් දිනය අපට සිහිපත් කරන්නේ බලය හෝ අවි නොව, *ධර්මය, කරුණාව සහ සාමය* මගින්ම සමාජයක් සංවර්ධනය කළ හැකි බවයි. වෛරය මැඩ පවත්වා, මෛත්‍රීය වර්ධනය කරමින්, දානය, සීලය සහ භාවනාව ජීවිතයට එක් කරගැනීමට දුරුතු පුන් පොහෝ දිනය අප සැමට මහඟු ආරාධනාවක් වේ.

මෙවන් පින්බර දිනයක, සියලු සත්ත්වයන්ට නිදුක් නිරෝගී සුවය, සාමය සහ සතුට උදා වේවායි ප්‍රාර්ථනා කරමින්, සසර දුකින් මිදී නිවන් මගට පියනගන්නට ශක්තිය හා ධෛර්යය ලැබේවායි හදවතින්ම ප්‍රාර්ථනා කරමු.

🌸 *සියලු දෙනාටම සරණීය, ශාන්තිමත් උතුම් දුරුතු පුන් පොහෝ දිනයක් වේවා!* 🌸

As we step into 2026, we celebrate not just a new year, but new opportunities to learn, discover, and grow together.Happ...
31/12/2025

As we step into 2026, we celebrate not just a new year, but new opportunities to learn, discover, and grow together.

Happy New Year 2026! 🧬✨


🎄✨ Christmas arrives like a soft pause in a loud world.💫A sacred reminder that love was born to heal, hope was given to ...
25/12/2025

🎄✨ Christmas arrives like a soft pause in a loud world.💫

A sacred reminder that love was born to heal, hope was given to guide, and light was sent to overcome every darkness. Today is not just about celebration — it’s about remembering the power of faith, kindness, and quiet miracles.

In a life filled with deadlines, dreams, struggles, and silent prayers, Christmas gently tells us to slow down and look around. To be thankful for lessons learned, for strength we didn’t know we had, and for people who made the journey easier just by being there.

May this holy day fill our hearts with peace that calms every storm, joy that shines beyond circumstances, and love that stays long after the decorations are gone. Let Christmas renew our spirits, strengthen our faith, and remind us that even the smallest light can change everything.

🎅🎄 Wishing you a blessed and beautiful Christmas — may today bring warmth to your soul and hope to every tomorrow.🎅🎄



𝐓𝐡𝐞 𝐁𝐢𝐨𝐜𝐡𝐞𝐦𝐢𝐜𝐚𝐥 𝐑𝐨𝐥𝐞 𝐨𝐟 𝐒𝐧𝐚𝐤𝐞 𝐕𝐞𝐧𝐨𝐦 𝐏𝐫𝐨𝐭𝐞𝐢𝐧𝐬.Snake venom is a complex mixture of proteins, enzymes, and peptides that se...
19/12/2025

𝐓𝐡𝐞 𝐁𝐢𝐨𝐜𝐡𝐞𝐦𝐢𝐜𝐚𝐥 𝐑𝐨𝐥𝐞 𝐨𝐟 𝐒𝐧𝐚𝐤𝐞 𝐕𝐞𝐧𝐨𝐦 𝐏𝐫𝐨𝐭𝐞𝐢𝐧𝐬.

Snake venom is a complex mixture of proteins, enzymes, and peptides that serves multiple purposes, including prey immobilization, defense, and digestion. Although most people know its toxic effects, the venom plays an important biochemical role in breaking down prey tissues, facilitating digestion.

Key enzymes in snake venom include proteases, phospholipases, and hyaluronidases. Proteases break down proteins into smaller peptides and amino acids, effectively “pre-digesting” the prey before it reaches the snake’s stomach. Phospholipases target cell membranes, causing cell lysis and releasing nutrients. Hyaluronidases act as “spreading factors,” increasing tissue permeability and allowing other venom components to diffuse more efficiently.

By starting the digestive process externally, venom allows snakes to consume large prey relative to their body size and reduces the risk of injury from struggling prey. The quick digestion allows the snake to extract energy efficiently, and helps it to survive during long periods without food.

Snake venom proteins serve as a powerful digestive aid in addition to their toxic effects. This shows remarkable biochemical specialization of reptiles.

𝐻𝑖𝑟𝑢𝑛𝑖 𝑅𝑎𝑡ℎ𝑛𝑎𝑦𝑎𝑘𝑒
𝐵𝑆/2023/066
1𝑠𝑡 𝑦𝑒𝑎𝑟

Reference:
_Bottrall, J. L., et al. Proteolytic activity of Elapid and Viperid snake venoms and its implication to digestion_ https://pmc.ncbi.nlm.nih.gov/articles/PMC3086185/

🌕🪔 උතුම් උඳුවප් පුන් පොහෝ දිනය අදයි..!ඉන්දියාවේ අශෝක අධිරාජයාණන්ගේ දුව, අරහත් මහින්ද ස්ථවිරයන් වහන්සේගේ සහෝදරිය වූ සංඝමි...
04/12/2025

🌕🪔 උතුම් උඳුවප් පුන් පොහෝ දිනය අදයි..!

ඉන්දියාවේ අශෝක අධිරාජයාණන්ගේ දුව, අරහත් මහින්ද ස්ථවිරයන් වහන්සේගේ සහෝදරිය වූ සංඝමිත්තා ථෙරණියන් වහන්සේ, බුදුරජාණන් වහන්සේ බුද්ධත්වය අවබෝධ කළ ජය ශ්‍රී මහා බෝධියේ දකුණු ශාඛාවක් රැගෙන ලංකාවට වැඩියහ.

සංඝමිත්තා ථෙරණියන්ගේ වැඩම කිරීමත් සමඟ ලංකාවේ භික්ෂුණී ශාසනය පිහිටුවන ලදී. මේ හේතුවෙන් රැජිණ අනුලා දේවිය ඇතුළු කාන්තාවන් උපසම්පදාව ලැබූහ. මෙය ලංකාවේ කාන්තාවන්ගේ ආධ්‍යාත්මික උන්නතියට මහත් පිටිවහලක් විය.

එබැවින් උඩුවප් පුන් පොහෝ දිනය ලංකා බෞද්ධ ජනතාවට අතිශය උතුම් දිනයකි.

ඔබ සැමට සුපින්බර උඳුවප් පුර පසළොස්වක පොහෝ දිනයක් වේවා..!
🪷🙏✨

𝐓𝐡𝐞 𝐂𝐞𝐥𝐥𝐮𝐥𝐚𝐫 𝐓𝐢𝐦𝐞 𝐌𝐚𝐜𝐡𝐢𝐧𝐞: 𝐒𝐜𝐢𝐞𝐧𝐭𝐢𝐬𝐭𝐬 𝐃𝐢𝐬𝐜𝐨𝐯𝐞𝐫 𝐭𝐡𝐞 '𝐑𝐞𝐬𝐞𝐭 𝐁𝐮𝐭𝐭𝐨𝐧' 𝐭𝐨 𝐑𝐞𝐰𝐢𝐧𝐝 𝐂𝐞𝐥𝐥 𝐅𝐚𝐭𝐞. 🔬In a major breakthrough for bioc...
29/11/2025

𝐓𝐡𝐞 𝐂𝐞𝐥𝐥𝐮𝐥𝐚𝐫 𝐓𝐢𝐦𝐞 𝐌𝐚𝐜𝐡𝐢𝐧𝐞: 𝐒𝐜𝐢𝐞𝐧𝐭𝐢𝐬𝐭𝐬 𝐃𝐢𝐬𝐜𝐨𝐯𝐞𝐫 𝐭𝐡𝐞 '𝐑𝐞𝐬𝐞𝐭 𝐁𝐮𝐭𝐭𝐨𝐧' 𝐭𝐨 𝐑𝐞𝐰𝐢𝐧𝐝 𝐂𝐞𝐥𝐥 𝐅𝐚𝐭𝐞. 🔬

In a major breakthrough for biochemistry and regenerative medicine, scientists have uncovered a novel method to "rewind" specialized cells back to their earliest, most flexible state, essentially finding a cellular time machine. This revolutionary discovery, detailed in the journal Nature Biotechnology, challenges the long-held belief that once a stem cell differentiates into a mature tissue type—like a skin or nerve cell—its fate is sealed.
The Secret Vault: Redefining P-bodies
The core of this finding lies within a tiny structure inside the cell's cytoplasm known as the P-body (Processing body). For years, researchers mostly viewed P-bodies as cellular "junk drawers" where the cell simply sent RNA (the instructional molecules derived from DNA) to be destroyed.

However, this new research reveals that P-bodies are, in fact, highly organized storage vaults or molecular filing cabinets. They don't destroy the RNA; instead, they actively sequester—or hide away—specific instructional molecules that encode the traits and genetic programs from a cell's preceding developmental stages. By hiding these old instructions, the P-body actively locks the cell into its mature identity.

The 'Rewind' Mechanism
The breakthrough occurred when scientists figured out how to chemically destabilize or temporarily break open these P-bodies.
When the storage vaults were disrupted, the sequestered RNA molecules—the instructions for a previous developmental stage—were suddenly released back into the cell's machinery. This flood of old information caused the mature cell to regress to an earlier, more malleable state. This process of controlled dedifferentiation allowed researchers to efficiently generate two highly valuable cell types:
Primordial Germ-Cell-Like Cells (PGCLCs): Precursors to reproductive cells, crucial for studying infertility.
Totipotent-Like Cells: The "holy grail" of stem cell biology, capable of becoming any cell type in the body.
The study also pinpointed microRNAs (miRNAs) as the molecular "gatekeepers" that control which RNAs get stored inside the P-bodies, providing a non-genetic target for therapeutic intervention.
Future Implications for Medicine
This discovery introduces a fundamental new level of control over cell fate, holding massive promise for the future of medicine:
Regenerative Medicine: The ability to "rewind" easily accessible mature cells (like a patient's skin cells) back to a flexible state could allow scientists to grow replacement tissues or organs customized for the patient.
Disease Modeling: Researchers can now recreate the very earliest, most primitive stages of development in the lab, which is essential for studying how genetic diseases or developmental disorders originate.
This research marks a significant shift, proving that cellular identity is more fluid than previously believed, and that the key to unlocking the cell's past lies not just in the nucleus, but in the storage vaults hidden in its cytoplasm.

References
CU Boulder Today. (2025, November 3). Scientists discover new way to shape what a stem cell becomes. Retrieved from: https://www.colorado.edu/today/2025/11/03/scientists-discover-new-way-shape-what-stem-cell-becomes
Pessina P, Nevo M, Shi J, et al. (2025). Selective RNA sequestration in biomolecular condensates directs cell fate transitions. Nature Biotechnology. (Original research paper cited in the news article.)

𝐻. 𝑀. 𝐷. 𝑆. 𝐻𝑒𝑟𝑎𝑡ℎ
𝐵𝑆/2023/056
1𝑠𝑡 𝑦𝑒𝑎𝑟

𝐒𝐧𝐢𝐟𝐟𝐢𝐧𝐠 𝐎𝐮𝐭 𝐂𝐚𝐧𝐜𝐞𝐫: 𝐇𝐨𝐰 𝐁𝐢𝐨𝐜𝐡𝐞𝐦𝐢𝐬𝐭𝐫𝐲 𝐢𝐬 𝐔𝐧𝐥𝐨𝐜𝐤𝐢𝐧𝐠 𝐭𝐡𝐞 𝐁𝐨𝐝𝐲’𝐬 𝐂𝐡𝐞𝐦𝐢𝐜𝐚𝐥 𝐒𝐢𝐠𝐧𝐚𝐥𝐬.Early detection is one of the greatest ch...
26/11/2025

𝐒𝐧𝐢𝐟𝐟𝐢𝐧𝐠 𝐎𝐮𝐭 𝐂𝐚𝐧𝐜𝐞𝐫: 𝐇𝐨𝐰 𝐁𝐢𝐨𝐜𝐡𝐞𝐦𝐢𝐬𝐭𝐫𝐲 𝐢𝐬 𝐔𝐧𝐥𝐨𝐜𝐤𝐢𝐧𝐠 𝐭𝐡𝐞 𝐁𝐨𝐝𝐲’𝐬 𝐂𝐡𝐞𝐦𝐢𝐜𝐚𝐥 𝐒𝐢𝐠𝐧𝐚𝐥𝐬.

Early detection is one of the greatest challenges in modern medicine, especially for cancers that often remain hidden until they reach advanced stages. Recently, biochemists and medical researchers have begun exploring an unusual but promising source of information: the body’s own chemical scent.
Our bodies constantly release volatile organic compounds (VOCs) — small molecules that easily evaporate and can be detected in the air we exhale, in sweat, urine, or other body fluids. These VOCs are byproducts of metabolism, and when cells undergo abnormal changes, such as those caused by cancer, the pattern of these compounds can shift dramatically. In simple terms, disease alters the body’s biochemical “odor fingerprint.”
The link between VOCs and cancer lies in the unique biochemical changes within cancer cells. Malignant cells often display altered energy metabolism, oxidative stress, and abnormal enzyme activity, all of which can influence the types and amounts of VOCs they produce. By analysing these patterns using advanced tools such as gas chromatography–mass spectrometry (GC-MS) or novel sensor arrays, scientists are moving closer to the possibility of detecting cancer at very early stages, sometimes even before symptoms appear.

The potential benefits of this approach are striking. VOC analysis could allow for non-invasive testing through a simple breath or urine sample, making it more comfortable and accessible than biopsies or complex imaging scans. Early diagnosis would greatly improve the chances of successful treatment and survival. Furthermore, VOC signatures may provide valuable information on how patients are responding to therapies, paving the way for more personalized medical monitoring.
Despite these advantages, significant challenges remain. VOC patterns are not influenced by cancer alone; they can also vary with diet, lifestyle, environmental exposures, or even the balance of microbes in the gut. This complexity makes it difficult to establish standardized markers that are both sensitive and specific. To move forward, large-scale clinical trials and rigorous biochemical validation are essential.

Nevertheless, the vision for the future is compelling. We may one day see clinics equipped with “biochemical breath tests” that screen for multiple cancers within minutes. With the combined progress of biochemistry, advanced sensor technology, and artificial intelligence for data analysis, this once futuristic idea is becoming an achievable reality.
Research into VOC-based cancer detection reminds us of the power of biochemistry to translate invisible molecular signals into meaningful medical tools. By listening to the body’s chemical whispers, science is opening the door to earlier, easier, and more effective ways to fight one of the world’s most challenging diseases.

𝑉𝑒𝑛𝑢𝑙𝑖 𝑉𝑜𝑛𝑎𝑟𝑎 𝐺𝑢𝑛𝑎𝑤𝑎𝑟𝑑ℎ𝑎𝑛𝑎
𝐵𝑆/2022/244
𝐹𝑖𝑟𝑠𝑡 𝑌𝑒𝑎𝑟

𝐄𝐙𝐒𝐩𝐞𝐜𝐢𝐟𝐢𝐜𝐢𝐭𝐲: 𝐇𝐨𝐰 𝐀𝐈 𝐢𝐬 𝐑𝐞𝐯𝐨𝐥𝐮𝐭𝐢𝐨𝐧𝐢𝐳𝐢𝐧𝐠 𝐄𝐧𝐳𝐲𝐦𝐞 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡.Enzymes are the workhorses of biochemistry, catalyzing reaction...
21/11/2025

𝐄𝐙𝐒𝐩𝐞𝐜𝐢𝐟𝐢𝐜𝐢𝐭𝐲: 𝐇𝐨𝐰 𝐀𝐈 𝐢𝐬 𝐑𝐞𝐯𝐨𝐥𝐮𝐭𝐢𝐨𝐧𝐢𝐳𝐢𝐧𝐠 𝐄𝐧𝐳𝐲𝐦𝐞 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡.

Enzymes are the workhorses of biochemistry, catalyzing reactions essential for life and industrial processes alike. However, identifying the perfect enzyme-substrate combination is a challenging task. Enzyme active sites are not static; they change shape upon substrate binding—a phenomenon called induced fit. Moreover, some enzymes are promiscuous, capable of catalyzing multiple reactions. These complexities make predicting enzyme-substrate compatibility difficult, and traditional experimental approaches are often slow and limited.

To address this challenge, researchers at the University of Illinois Urbana-Champaign, led by Professor Huimin Zhao, have developed EZSpecificity, an artificial intelligence (AI)-powered tool that predicts which substrates are most likely to fit a given enzyme. The tool combines a machine learning algorithm with a large dataset derived from both experimental and computational studies, making it far more accurate than previous models. The team collaborated with Professor Diwakar Shukla’s group, performing millions of docking simulations to examine how enzymes of different classes adapt their shapes around various substrates. By integrating enzyme sequence, structural data, and flexibility information, the AI model can now predict enzyme-substrate specificity with unprecedented accuracy.

EZSpecificity was tested against ESP, the leading enzyme specificity model, in four scenarios designed to simulate real-world applications. The results demonstrated a clear advantage for EZSpecificity, which achieved 91.7% accuracy for top substrate predictions, compared to 58.3% accuracy for ESP. Experimental validation with eight halogenase enzymes and 78 substrates further confirmed the model’s reliability. This validation highlights the tool’s potential not only for research but also for practical applications in medicine, biotechnology, and industrial catalysis.
The availability of EZSpecificity has important implications for the scientific community. Researchers can now input a substrate and an enzyme sequence into the user-friendly interface to predict the likelihood of a successful pairing. This capability accelerates the process of enzyme selection, facilitating the design of efficient catalysts for drug development, synthesis of bioactive molecules, and various manufacturing processes. Looking ahead, the researchers plan to expand EZSpecificity to analyze enzyme selectivity, predicting which specific sites on a substrate an enzyme prefers, and to refine the model further with more experimental data.
EZSpecificity represents a powerful integration of biochemistry and AI, demonstrating how computational tools can complement experimental research to solve complex biological problems. By combining large datasets, machine learning, and detailed simulations, the tool offers a faster and more reliable way to explore enzyme-substrate interactions. Its development not only advances our understanding of enzyme specificity but also opens new avenues for innovation across medicine, biotechnology, and industrial applications.

References :
Zhao, H.; Shukla, D. EZSpecificity: AI-powered prediction of enzyme-substrate specificity. Nature, 2025.
University of Illinois Urbana-Champaign. AI Tool Predicts Enzyme-Substrate Compatibility. 2025.

𝐵𝑆/2023/077
1𝑠𝑡 𝑦𝑒𝑎𝑟
𝐾𝑢𝑙𝑎𝑡ℎ𝑢𝑛𝑔𝑒 𝐾.𝐺.𝐻.𝐾.

𝐓𝐡𝐞 𝐁𝐢𝐨𝐜𝐡𝐞𝐦𝐢𝐜𝐚𝐥 𝐇𝐨𝐮𝐫𝐠𝐥𝐚𝐬𝐬: 𝐔𝐧𝐝𝐞𝐫𝐬𝐭𝐚𝐧𝐝𝐢𝐧𝐠 𝐀𝐠𝐢𝐧𝐠 𝐚𝐭 𝐭𝐡𝐞 𝐌𝐨𝐥𝐞𝐜𝐮𝐥𝐚𝐫 𝐋𝐞𝐯𝐞𝐥.IntroductionAging is a biological certainty that r...
19/11/2025

𝐓𝐡𝐞 𝐁𝐢𝐨𝐜𝐡𝐞𝐦𝐢𝐜𝐚𝐥 𝐇𝐨𝐮𝐫𝐠𝐥𝐚𝐬𝐬: 𝐔𝐧𝐝𝐞𝐫𝐬𝐭𝐚𝐧𝐝𝐢𝐧𝐠 𝐀𝐠𝐢𝐧𝐠 𝐚𝐭 𝐭𝐡𝐞 𝐌𝐨𝐥𝐞𝐜𝐮𝐥𝐚𝐫 𝐋𝐞𝐯𝐞𝐥.

Introduction

Aging is a biological certainty that results in the progressive decline of cellular and physiological processes. It is caused by cumulative molecular damage and influenced by genetics, metabolism and environmental stresses. Understanding the biochemical pathways of aging reveals why our bodies lose energy over time and provides us insight into how this process can be slowed to realize healthy longevity.

Biochemical Mechanisms of Aging
1. Oxidative Stress and Free Radicals
One of the most famous biochemical hypotheses for aging is the free radical theory. During normal metabolism, cells produce reactive oxygen species (ROS). Such as superoxide and hydrogen peroxide. These are neutralized by antioxidants like superoxide dismutase and catalase. However with age, antioxidant defenses weaken and this allows ROS to damage DNA lipids and proteins. Oxidative stress accelerates cellular degeneration and contributes to the development of aging related diseases.

2. Decline of Mitochondria
Mitochondria are not only the major sources of cellular energy but also the major sources of ROS. Mitochondrial DNA mutations accumulate over time and cause diminished ATP synthesis and oxidative damage. This dysfunction incapacitates tissues and results in neurodegenerative and cardiovascular disease.

3. DNA Damage and Telomere Shortening
DNA repair mechanisms protect the genome against damage caused by toxins and radiation. While their effectiveness deteriorates over time mutations accumulate. Telomeres are DNA repeats found at the chromosome ends that shorten with each cell division. Upon reaching critically short lengths, they cause cellular senescence or apoptosis, which is the process of programmed cell death.

4. Loss of Proteostasis
Proteostasis is the balance between protein synthesis, folding and degradation. Aging leads to an imbalance in the form of the accumulation of misfolded or aggregated proteins. The aggregates disrupt normal cellular processes and are components of diseases such as Alzheimer's disease. Defective autophagy and proteasome add to this imbalance, pointing towards the biochemical susceptibility of aging cells.

5. Epigenetic Changes and Inflammation
Epigenetic modifications through DNA methylation and histone alteration regulate gene expression without altering the genetic code. Aging installs abnormal epigenetic marks, suppressing protective genes and activating destructive ones. Concurrently, old and damaged cells release inflammatory mediators (pro-inflammatory signaling molecules) which creates a chronic, low-grade systemic inflammation known as "inflammaging”. This biochemical inflammation drives tissue degeneration and promotes the development of chronic diseases.

Biochemical Strategies to Delay Aging
Although aging cannot be avoided, a few biochemical interventions can be slowed down.
Caloric restriction reduces oxidative damage and improves cellular maintenance.
Antioxidant drugs like vitamins C and E quench free radicals. However long term effectiveness is questionable.
Senolytic drugs clear out senescent cells and reduce inflammation.
Sirtuin activators such as the polyphenol resveratrol enhance cellular stress resistance and promote the maintenance of metabolic homeostasis.
Epigenic control using sophisticated gene editing tools may reverse youthful gene expression.
Can Biochemistry Reverse Aging?
Evidence suggests that while the reversal of aging is not yet feasible, targeted biochemical treatments can restore some level of youthful cellular function. Model organism experiments demonstrate extended lifespan through the alteration of metabolic and genetic mechanisms. These therapies underscore that aging is not solely genetically predetermined but is fundamentally biochemical and responsive to manipulation through molecules, enzymes and cellular signaling pathways that can be engineered to some extent. In humans, the focus has shifted from the pursuit of eternal longevity to the expansion of health span; the pursuit of eternal longevity the objective of maintaining youthfulness and remaining disease-free during the aging process.

Conclusion
Aging is a complex biochemical process that is driven by oxidative stress, mitochondrial dysfunction, DNA damage, protein dysregulation and epigenetic shift. All of these processes contribute to a cumulative loss of cellular stability and a reduction in physiological function. Time cannot be halted. However understanding the chemistry of aging allows science to regulate its pace, converting aging into a controlled process rather than an unyielding decay.

References
https://www.biotech-asia.org/vol21no1/bridging-biochemistry-and-aging-a-journey-towards-prolonged-health-span/

𝐺.𝐶.𝐿. 𝑊𝐼𝐽𝐸𝑆𝐼𝑅𝐼
𝐵𝑆/2023/069
1𝑆𝑇 𝑌𝐸𝐴𝑅

𝐌𝐨𝐥𝐞𝐜𝐮𝐥𝐚𝐫 𝐓𝐚𝐫𝐠𝐞𝐭𝐬 𝐚𝐧𝐝 𝐌𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐭𝐢𝐜 𝐈𝐧𝐬𝐢𝐠𝐡𝐭𝐬 𝐨𝐟 𝐅𝐢𝐯𝐞 𝐊𝐞𝐲 𝐓𝐫𝐚𝐝𝐢𝐭𝐢𝐨𝐧𝐚𝐥 𝐇𝐞𝐫𝐛𝐚𝐥 𝐂𝐨𝐦𝐩𝐨𝐮𝐧𝐝𝐬.               Traditional herbal re...
14/11/2025

𝐌𝐨𝐥𝐞𝐜𝐮𝐥𝐚𝐫 𝐓𝐚𝐫𝐠𝐞𝐭𝐬 𝐚𝐧𝐝 𝐌𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐭𝐢𝐜 𝐈𝐧𝐬𝐢𝐠𝐡𝐭𝐬 𝐨𝐟 𝐅𝐢𝐯𝐞 𝐊𝐞𝐲 𝐓𝐫𝐚𝐝𝐢𝐭𝐢𝐨𝐧𝐚𝐥 𝐇𝐞𝐫𝐛𝐚𝐥 𝐂𝐨𝐦𝐩𝐨𝐮𝐧𝐝𝐬.

Traditional herbal remedies have long been trusted – and now much more modern science is revealing their power at the molecular level. Natural products have been regarded as promising resources for the discovery of drug candidates, particularly for treatment of chronic diseases based on their structural diversity and bioactivity. Scientists are probing the mechanisms of five important compounds- plumbagin, β-eudesmol, garcihombronane D, neferine and iriflophenone 3-C-β-D-glucoside in the body. These agents present powerful mechanisms of action in their roles against cancer, inflammation dispelling, antioxidant role performance, heart shielding and nervous system protecting. The agents achieve this by influencing crucial communication pathways in cells, such as NF-κB, PI3K/Akt, and mTOR. Ultimately, these natural molecules help regulate vital cell functions like cell death (apoptosis), self-cleaning (autophagy), stress responses, and the formation of new blood vessels (angiogenesis).

Despite the exciting potential, these natural compounds face practical challenges that must be overcome before they can be widely used as modern medicines. Problems include poor absorption into the body (low bioavailability), difficulty dissolving in water (poor water solubility) and a lack of clinical studies to prove their effectiveness in humans. For instance, plumbagin has poor water solubility and potential toxicity, while β-eudesmol suffers from low bioavailability. Future research needs to focus on creating better ways to deliver these drugs into the body, perhaps using nanotechnology, and conducting more rigorous clinical trials to confirm their safety and optimal dosage. Merging this traditional knowledge with modern molecular biochemistry is essential for developing new drugs from this rich natural source.
References: - Chinonso, A. D., Kayode, A. A., Adondua, M. A., & Chinekwu, U. K. (2025). Biochemistry of Traditional Herbal Compounds and their Molecular Targets. Pharmacognosy Reviews, 19(37).

𝑀.𝑅.𝑆. 𝐽𝑎𝑦𝑎𝑠𝑟𝑒𝑒𝑛𝑖 𝑀𝑒𝑛𝑖𝑘𝑒 𝐵𝑆/2023/062 𝐹𝑖𝑟𝑠𝑡 𝑦𝑒𝑎𝑟

🎗 *World Diabetes Day* 💉1 in 10 adults is living with diabetes — and many don’t even know it.📌 This day is a reminder to...
14/11/2025

🎗 *World Diabetes Day* 💉

1 in 10 adults is living with diabetes — and many don’t even know it.

📌 This day is a reminder to take charge of our health and be proactive! 🎗️

What can you do to prevent diabetes?
🩺 Get tested regularly
🥗 Eat balanced meals
🏃 Stay active
💧 Stay hydrated

Be aware of the symptoms of this disease!
⚠️ Excessive thirst
⚠️ Frequent urination
⚠️ Unexplained weight loss
⚠️ Fatigue and blurred vision

Knowing them early can save your life.

*Sugar is sweet 🍬 — but your health is sweeter!* 💝



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