11/06/2026
๐ข New Journal Paper Published
We congratulate our dedicated faculty researchers and students from the College of Arts and Sciences, along with their co-authors from the university, for the successful publication of their latest research paper under Siyasig.
๐ก๐๐ช ๐๐ข๐จ๐ฅ๐ก๐๐ ๐ฃ๐๐ฃ๐๐ฅ ๐ฃ๐จ๐๐๐๐ฆ๐๐๐
โMine-Derived Metal-Resistant Bacteria as Bionanofactories for Nanoparticle Synthesis: Mechanisms and Biomedical Potentialโ
๐๐ต๐ฟ๐ถ๐๐๐ผ๐ฝ๐ต๐ฒ๐ฟ ๐. ๐ฅ๐ฒ๐น๐ฎ๐๐ถ๐๐ผ
Graduate School
University of the Philippines Los Baรฑos
๐๐ฏ๐๐๐ฟ๐ฎ๐ฐ๐:
Deciphering various mechanisms of metal resistance in bacteria has been in progress over the past decades. It is currently being applied and explored in various fields, including nanoparticle (NP) biosynthesis. The link between bacterial resistance to metal(loid) ions and their ability to synthesize NPs has been reported by various researchers independently. Thus, this review presents the role of various metal resistance mechanisms in bacterial-mediated NP synthesis, emphasizing the promising potential of metal-resistant mine-derived bacteria as biological factories for synthesizing NPs. Several mechanisms of metal resistance that contribute to the formation of NPs include the production of exopolysaccharides (EPS), reactions catalyzed by proteins and enzymes, and reduction reactions involving thiol-containing molecules. The electrostatic attractive forces of the functional groups in the capsule, cell wall, and cell membrane with the metal ions are responsible for metal ion adsorption and NP formation. Furthermore, enzymes like c-cytochromes, different reductases like arsenate, mercuric, and nitrate reductases, as well as several thiol-containing biomolecules like metallothioneins (MTs) and glutathione (GSH) also play vital roles in the sequestration, reduction, and precipitation of toxic metal(loid) ions into NPs. Mining sites, being heavily metal-contaminated environments, are undoubtedly rich reservoirs of metal resistance as revealed by metagenomics studies. It confirms the presence of diverse metal-resistant bacterial strains capable of synthesizing NPs with a wide range of applications, particularly in the biomedical field. Risk-benefit analysis and growth condition management in large-scale production still impede biosynthesized NPs towards clinical and industrial translation. Hence, future research should focus on understanding the exact mechanism used by mine-derived metal-resistant bacteria in synthesizing NPs, standardizing formulations appropriate for human use, and optimizing the reaction for large-scale production.
DOI: https://doi.org/10.5281/zenodo.20440629
Published in SIYASIG: The Southern Luzon Journal of Science
Vol. I | 2026 | pp. 2โ16