Cláudio Gomes Lab - Protein Misfolding and Amyloids in Biomedicine
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- Portugal
- Lisbon
- Cláudio Gomes Lab - Protein Misfolding and Amyloids in Biomedicine
We study proteins and molecular mechanisms of protein misfolding and
aggregation in Alzheimer's Disease and in protein folding diseases
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Lisbon
1749-016LISBOA
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Protein (mis)folding in biomedicine
Our research focuses on understanding biochemical phenomena related to protein structure and (mis)folding in the context of complex biomedical problems such as those arising in Protein Folding Diseases.
Through a multidisciplinary experimental approach and solid collaborative network, we seek to identify disease-causing mechanisms resulting from protein misfolding and aggregation through characterization of basic biological processes relevant in folding disease that may be targeted by biologics or small molecules to mitigate the pathological outcomes.
For instance, we are studying how amyloid formation in neurodegenerative diseases such as Alzheimer's Disease and Amyotrophic Lateral Sclerosis is regulated by neuronal metal ions and by regulatory alarmin proteins that are highly abundant in the nervous systems in response to neuroinflammation.
In another example, we are investigating the folding of mitochondrial enzymes involved in metabolic disease in connection with accumulating metabolites that promote protein post translational modifications, whose role in pathophysiology we seek to uncover.
