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Veterinary Integrative Sciences

The official peer-reviewed journal of the Faculty of Veterinary Medicine, Chiang Mai University, Thailand.

26/09/2026

Structure of the heart wall and existence of the blood cells in the heart of the dog-faced water snake Cerberus rynchops (Schneider, 1799)
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A plurality of investigations on the heart structure of reptiles has been extensively reported; however, it has yet to conduct studies in Cerberus rynchops, the so-called common estuarine water-snake. In this current study, we histologically started to examine the heart wall of the atrium, ventricle chambers, and study the existence of the blood cells in the heart of s*xually mature females. The selected samples were those C. rynchops from the Paknam Pranburi Estuary in Thailand using accurate histochemical techniques. The results showed that the heart structure of C. rynchops consisted of three primary compartments (sinus venosus, atrium, and ventricle). All compartments were surrounded by the heart wall, which was typically classified into three layers (the epicardium, the myocardium, and the endocardium), as likely seen in underlying patterns of reptilian heart. In particular, the myocardium of the ventricle in this snake was the thickest layer of the heart wall. Major components of the cardiac muscle fibers in the myocardium with green/ pinkness colors were associated with Massonʼs trichrome and Periodic Shift reagent methods, indicating to present various fibers and glycoproteins. Consequently, several blood cells were also detected in different areas. The normal and atretic red blood cells were seen in the cardiac fluid, as referred to the fluid inside the heart sac, whereas the mast cell was also observed in the heart wall especially myocardium.
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https://he02.tci-thaijo.org/index.php/vis/article/view/141530

26/09/2026

Histopathology of kidney and liver in the captive broodstock (Rastrelliger brachysoma) during its juvenile stage
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This is the first study which explained the histopathology in kidney and liver of the captive broodstock (Rastrelliger brachysoma) during its juvenile stage, to assess the health status. All fishes (n = 24) with a mean of 5.02±0.87 (SD) cm in total length, were collected during October to December 2013 and processed using standard histological protocols. Conforming to histological observation, kidney and liver parenchyma in this species were clearly altered. The most melanomacrophage center had found to be highly organized in these tissues, whereas a large number of the vacuolar structure in the hepatocyte was shown as an empty space, as also called the hepatocellular lipidosis. All lesions in the abnormal kidney and liver may be related to their reduced functions as well as health status of R. brachysoma under captive conditions.
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https://he02.tci-thaijo.org/index.php/vis/article/view/141594

25/09/2026

The effect of curcumin on growth performance, blood biochemistry and antioxidant activities in boiler chickens
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The antioxidant effects of Curcumin that extracted from Curcuma longa not only reduce free radical but also improve growth performances in broilers. A study was conducted to investigate the effects of Curcumin on blood biochemistry parameters and antioxidant status of broilers exposed to varies of raising systems. The 180 boilers were randomly assigned into 6 categories compose of 3 raising systems; semi-intensive and stocking densities of 10 and 16 birds/m2 in each group fed with control diet mixed with and without 10% Curcumin. The result show that the activities of antioxidant systems, lipid peroxidation were gradually increased in highest stocking density (16 birds/m2). However, the level of lipid peroxidation was reduced while, catalase and superoxide dismutase activities were significantly increased in blood chickens as also the growth performances and blood biochemistry that improved after fed with 10% Curcumin. This finding indicates that Curcumin has potentiated to reducing the oxidative stress, activated antioxidant enzyme activities and improve the growth performance of broilers raised under stress condition.
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https://he02.tci-thaijo.org/index.php/vis/article/view/141603

25/09/2026

Carcinogenicity and proteomic analysis of N-Nitrosodiethylamine in rats
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N-Nitrosodiethylamine (NDEA), a probable human carcinogen, is commonly used in rodent experimental hepatocarcinogenesis research. We evaluated both clastogenicity and carcinogenicity in rats using various concentrations of NDEA via a liver micronucleus assay and a medium-term carcinogenicity test. The administration of repeated NDEA injections ranging from 10 to 50 mg/kg bw together with partial hepatectomy resulted in significantly more liver micronuclei compared to control rats, while the mitotic index was indifferent. However, the highest dose (50 mg/kg bw) was lethal to the rats. Similarly, medium-term exposure at 100 mg/kg bw of NDEA increased the formation of glutathione S-transferase placental form (GST-P) positive foci, a preneoplastic lesion of liver cancer in rats. A proteomic analysis revealed overexpression of hepatic proteins involved in the PI3K/Akt/mTOR pathway after treatment with NDEA. This pathway may play a key role in the mechanisms that influence NDEA-initiated hepatocarcinogenesis in this model. In conclusion, the amount of NDEA used in the present study can be considered as clastogenic and carcinogenic to rat hepatocytes. This finding can further our knowledge concerning the establishment of experimental cancer chemoprevention models in rats.
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https://he02.tci-thaijo.org/index.php/vis/article/view/124770

24/09/2026

Procedure for performing a fixed microscopic specimen of the go**ds of fish
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This study aims to provide a procedure for performing microscopy in fish go**ds. Specimens used in this study were the ovaries and te**es of fish collected in the Mekong Delta from April to July 2022. Organs at five different stages for each s*x (o***y diameter from 1.16 cm in stage I to 4.04 cm in stage V; te**is diameter from 0.42 in stage I to 2.39 in stage V) were studied in this procedure. The results showed that both ovaries and te**es needed to be fixed at 4% formol for 24 h and under running water for eight hours. Ovaries and te**es were then immersed in 500 ethanol for 24 h to initiate dehydration. Results showed that the time for dehydration and paraffin infiltration was longer in the o***y (26 to 55 h across stages) than in the te**is (25 to 26 h across stages). The mean staining time of the o***y was 1.5 min (stage I) to 3.5 min (stage V) in Hematoxylin and 50 s (stage I) to 140 s (stage V) in Eosin. Whereas the staining time of te**is was shorter, 1 min (stage I) to 3 min (stage V) in Hematoxylin and 30 s (stage I) to 90 s (stage V) in Eosin. This study provides a reference for further studies on the histological structure of fish go**ds. These results could be applied to fish species inside and outside the Mekong Delta.
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https://he02.tci-thaijo.org/index.php/vis/article/view/259722

24/09/2026

Acute toxicity evaluation of methanol, ethanol and aqueous extracts of Balanophora latisepala (V.Tiegh.) Lec.
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Balanophora latisepala has been used in traditional medicine in Vietnam for many years with both proven and unproven scientific proofs. This study aimed to evaluate the acute toxicity effects of B. latisepala by testing safety parameters of hot water, ethanol and methanol extracts of B. latisepala in Mus musculus. The acute toxicity was studied according to the World Health Organisations guideline for the evaluation of the safety and efficacy of herbal medicines. During study, a single dose of 1000, 2000 and 5000 mg/kg of each extract was orally administered to Swiss mice. To determine the median lethal dose, experimental mice were observed in behavior and mortality for 72 hours. Data of organ weight, histopathology,biochemical and hematology were also collected. The results showed that hot water, ethanol and methanol extracts at a dose of 5000 mg/kg did not induce mortality in experimental mice; therefore, LD50 is not determined. Insignificant changes were found in relative organ weight at dose 5000 mg/kg for all of the extracts. Similarly, no significant differences were observed in biochemical indices and organ histology. However, changes in hematological indices in both male and female mice were noticed. In male mice, it is likely that all B. latisepala extracts induced anemia. Moreover, clotting or bleeding abnormalities were also observed in female mice. Methanol extracts had the highest effect to hematology indices (p

23/09/2026

Multivariate analysis of morphometric traits to differentiate the indigenous chicken reared under different Agro-ecologies of Ethiopia
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This is to differentiate indigenous chickens at different agro-ecologies based on morphometric traits using multivariate analysis. Morphometric data were collected from a total of 520 (130 male and 390 female) adult indigenous chickens. Traits scored were body weight, body length, breast circumference, wingspan, shank length, shank circumference, comb length, wattle length, earlobe length and beak length. Ten quantitative traits for both s*xes were subjected to the stepwise discriminant analysis, of which four (wingspan, live body weight, shank circumference, and body length) in females and two of them (shank length, and wingspan) in males were identified as the best discriminating variables. CAN1 and CAN2 were extracted with 61.5% and 38.6% of the total variation in females, respectively and CAN1 (89.3%) and CAN2 (10.7%) of the total variation in parameters of male chicken populations. The higher classification rates were obtained in highland agroecology for female (64.7%) and midland for male (89.8%) chickens. Cross-validation with split–sample indicated that 62.7% (highland), 39% (lowland) and 59.3% (midland) success rate. The longest pairwise Mahalanobis distance was observed between midland and highland in male chickens and between lowland and highland in females, whereas the shortest distance was observed between lowland and highland in male and female chicken populations. The variations obtained in chickens of different agro-ecologies and s*xes considered as opportunities for genetic improvement of indigenous chicken genetic resources, because significantly related parameters could be used as selection criterion for improving body weight of Ethiopian indigenous chickens under small scale farmers.
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https://he02.tci-thaijo.org/index.php/vis/article/view/259870

23/09/2026

Effect of feeding pregnant gilts fermented potato extract protein on the prenatal development and semitendinosus muscle characteristics of newborn piglets
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The skeletal muscle, which largely forms meat, constitutes most of the body mass in pigs. Growth and meat quality mainly depend on the relationship between prenatal and postnatal development. Feed additives are used in the diet of pigs to improve production efficiency. In this study, we determined the effect of feeding pregnant pigs fermented potato extract protein on the characteristics of the skeletal muscles of newborn piglets. Ten Danish gilts (Large white x Landrace) were supplemented with or without fermented potato extract protein (5 gilts each) during the gestation period. After parturition, two neonate piglets from each sow were randomly selected, and the birth weight, organ weight, morphometrics, and the characteristics of the semitendinosus muscle, including weight, length, circumference, muscle cross-sectional area (MCSA), number of total muscle fibers, number of primary fibers, number of secondary fibers, and the ratio of secondary to primary (S:P) fibers were recorded. The piglets from sows that were fed fermented potato extract protein showed a significantly higher S:P ratio (p = 0.02) than those from control sows. The weights of the body and visceral organs at birth tended to be higher in the newborn offspring of the treated sows. The supplementation with fermented potato extract protein during gestation in pigs can increase the S:P ratio, which can be used to follow changes in the hyperplasia of secondary fibers in the fetus and might also affect postnatal growth.
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https://he02.tci-thaijo.org/index.php/vis/article/view/259639

22/09/2026

Prevalence, antimicrobial susceptibility profiles, and selected resistance genes of Salmonella spp. isolated from ducks in the Mekong Delta, Vietnam
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This study assessed the occurrence of Salmonella spp. in ducks sampled at selected sites in the Mekong Delta, Vietnam, and characterized antimicrobial susceptibility and selected antimicrobial resistance genes (ARGs) in the recovered isolates. Of 514 cloacal swabs collected at farms, smallholder households, and live-bird trading sites, 58 were positive (11.28%; 95% CI: 8.68–14.34), yielding 83 representative isolates. Positivity was numerically higher in semi-intensive and intensive systems than in scavenging systems, although the association was not statistically significant (P = 0.077). Resistance was most common to amoxicillin (84.34%) and amoxicillin/clavulanic acid (59.04%), followed by sulfamethoxazole/trimethoprim (31.33%), cefotaxime (21.69%), and doxycycline (20.48%). Sixty-eight isolates (81.93%) were resistant to at least two agents, whereas 11 (13.25%) met the class-based definition of multidrug resistance. At least one of the five tested ARGs was detected in 55 isolates (66.27%). The most frequent gene was aac(3)-IV (46.99%), followed by sul1 (22.89%), dfrA1 (15.66%), tetA (13.25%), and blaTEM (7.23%). The mismatch between phenotypic resistance and detection of the selected genes indicates that the five-gene panel captured only part of the resistance background. Overall, antimicrobial-resistant Salmonella was present in the sampled duck production settings, supporting continued surveillance, improved biosecurity, and prudent antimicrobial use.
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https://he02.tci-thaijo.org/index.php/vis/article/view/283260

22/09/2026

Histiocytic sarcoma in dogs
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Canine histiocytic sarcoma (CHS), also known as malignant histiocytosis is a very aggressive hematologic malignancy that has a high metastatic rate and mortality rate. CHS originates from white blood cells, namely histiocytes that commonly reside in soft tissue and connective tissue throughout the body. Microscopically, the cell morphology of this tumor sometimes is indistinguishable from other round cell tumors and carcinomas by using routine hematoxylin and eosin staining. Currently, immunohistochemistry is a valuable diagnostic tool for identifying types and cell of origin of the tumor that most CHS cells have dendritic cell immunophenotype (CD18+, CD11c+, MHCII+, CD11d-). The most currently available treatments for CHS are the combination of surgical excision, radiotherapy and chemotherapy, known as multimodal therapy, in order to increase treatment efficacy and survival time of dogs with CHS. Furthermore, the palliative treatment should be considered in CHS cases to improve the quality of life.
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https://he02.tci-thaijo.org/index.php/vis/article/view/141477

ที่อยู่

คณะสัตวแพทยศาสตร์ มหาวิทยาลัยChiang Mai
มหาวิทยาลัยChiang Mai
50100

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จันทร์	09:00 - 16:00
อังคาร	09:00 - 16:00
พุธ	09:00 - 16:00
พฤหัสบดี	09:00 - 16:00
ศุกร์	09:00 - 16:00

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เป็นคนแรกที่รู้ข่าว: เราจะส่งอีเมลแจ้งเมื่อ Veterinary Integrative Sciences โพสต์ข่าวสารและโปรโมชั่น อีเมลของคุณจะไม่ถูกนำไปใช้เพื่อวัตถุประสงค์อื่น และคุณสามารถยกเลิกการรับข่าวสารได้ทุกเมื่อ