19/08/2026
🧬 【學術交流與核心平台亮點】醫學院李建興教授：介紹「斑馬魚高通量藥效毒理與疾病模型服務平台」
本院於今日「115學年度高雄醫學大學健康產業核心技術服務平台交流會」中，由醫學院 李建興教授 代表進行分享，展現團隊主導之「斑馬魚高通量藥效毒理與疾病模型服務平台」的學術研發實力與平台執行規劃。
在生醫領域之藥物開發、天然物功能驗證或保養品成分研發初期，快速取得具備科學實證與統計顯著性之活體數據，為推動臨床前研究的關鍵基礎。李建興教授團隊所建置之斑馬魚平台，旨在為哺乳類動物實驗前提供高精準度之早期預篩機制，協助學術界與產業端深化生醫研究能量。
🔬 【斑馬魚實驗模型之四大核心優勢】
1. 高通量篩選機制：個體體積小、繁殖力強，極適合進行大規模及自動化之藥物篩選與數據收集。
2. 高度基因同源性：斑馬魚與人類基因同源性高達 70%，其篩選數據對人體生理反應具高價值之學術參考性。
3. 活體即時動態觀察：胚胎與幼魚體表具高度透明度，可直接進行器官發育、血流流速及細胞層次之即時顯微觀察。
4. 快速生理反應時程：發育週期短，可於極短時間內評估化合物對生理系統之影響，大幅提升實驗研發效率。
💡 【平台核心服務與研發範疇】
🧠 神經退化疾病篩選：評估化合物或天然物於緩解神經退化（如抗氧化、減少異常蛋白堆積）之生物活性。
✨ 美白功效評估：針對保養品成分或天然萃取物進行活體美白活性篩選，可於 48 小時內精準量化黑色素抑制效果，並獲取具備統計顯著性之科學數據。
🛡️ 安全性與毒性預篩：評估藥物或待測樣本於胚胎發育過程之致畸胎風險，建立早期安全性評估屏障。
🫀 心血管相關測試：團隊目前正積極推進行為與生理量化機制，未來將進一步提供藥物對心跳頻率、血流流速與心臟損傷之評估服務。
欲了解平台研究委託流程或相關技術諮詢，歡迎直接與醫學院李建興教授研究團隊聯繫：
✉️ 聯絡信箱：[email protected]
🧬 [Academic Exchange & Core Platform Highlights] College of Medicine Prof. Chien-Hsing Lee: Introducing the "High-Throughput Zebrafish Platform for Efficacy, Toxicity, and Disease Models"
At today's "115th Academic Year KMU Health Industry Core Technology Service Platform Exchange Conference," Prof. Chien-Hsing Lee from the College of Medicine delivered a special presentation, demonstrating the research capabilities and operational strategy of the "High-Throughput Zebrafish Platform for Efficacy, Toxicity, and Disease Models."
In the early stages of drug discovery, natural product validation, and skincare formulation research, obtaining statistically significant in vivo data with strong scientific evidence is a crucial prerequisite for advancing preclinical studies. The zebrafish platform established by Prof. Lee’s research team aims to provide a high-precision early prescreening mechanism prior to mammalian animal testing, thereby elevating biomedical research capabilities across academic and industrial sectors.
🔬 [Four Core Advantages of the Zebrafish Experimental Model]
High-Throughput Screening: Small organism size and high fecundity make it ideal for large-scale, automated drug screening and data collection.
High Genetic Homology: Zebrafish share up to 70% genetic homology with humans, rendering screening results highly relevant for referencing human physiological responses.
Real-Time In Vivo Observation: Embryos and larvae are optically transparent, enabling direct real-time microscopic observation of organogenesis, blood flow velocity, and cellular-level changes.
Rapid Physiological Response: An extremely short developmental cycle allows rapid assessment of compound effects on physiological systems, significantly enhancing R&D efficiency.
💡 [Core Platform Services & Research Scope]
🧠 Neurodegenerative Disease Screening: Evaluating the bioactivity of compounds or natural products in mitigating neurodegeneration (e.g., antioxidative activity, reduction of abnormal protein aggregation).
✨ Whitening Efficacy Evaluation: Conducting in vivo skin-whitening activity assays for skincare ingredients or natural extracts, enabling precise quantification of melanin inhibition and retrieval of statistically significant scientific data within 48 hours.
🛡️ Safety & Toxicity Prescreening: Assessing teratogenic risks of drugs or test samples during embryonic development to establish an early safety screen.
🫀 Cardiovascular Testing : The team is actively developing quantitative behavioral and physiological metrics to offer future evaluations of drug effects on heart rate, blood flow velocity, and cardiac damage.
For further information regarding research service procedures or technical consultation, please contact Prof. Chien-Hsing Lee's team:
✉️ Contact E-mail: [email protected]
