臺大基因體暨蛋白體醫學研究所（基蛋所）

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臺大基因體暨蛋白體醫學研究所（基蛋所）

歡迎加入臺大基蛋所，和我們一起探索轉譯醫學的奧秘^^

於基因科學相關之領域之中，本校已具有相關之研究及教育資源，如醫學院、生命科學院、生物資源暨農學院、及電機工程學院等其他相關跨領域之學院與系所、以及新近籌設之基因體醫學中心等等，確實已提供極為廣泛之基因科學相關研究能量及培育人才，但基因體暨蛋白體醫學研究所之成立及運作，將進一步提升各研究單位基因醫學相關之跨領域合作，並和臺大醫院充沛之優勢臨床研究能量與基礎相關學科之間充分結合，如此絕對能進一步提升臺大於基因醫學相關領域之發展及確立領導龍頭之地位。為補強各基因科學研究單位及臨床單位由於在專業背景及需求上之需求差異性所造成之互動及溝通不足，基因體暨蛋白體醫學研究所之成立雖然無法滿足基因科學相關領域所有的需求，卻能有助於解決上述之困境，並於臺大各學院間基因科學相關研究之橫向及縱向跨領域整合之中，扮演關鍵性的角色。

有別於其他臨床或基礎學科，本所以培育跨領域之臨床基因醫學研究領導人才為首要目標。為新一代、來自各種不同領域之專才提供量身訂製、涵蓋各領域之臨床基因醫學教育。使其在研究所的訓練中，具備臨床基因醫學應用、研發的知識、跨領域溝通學習的經驗及領導能力。這些領導人才將是國家競爭力中最重要的無形資產，將來可在社會的不同崗位上貢獻其智慧，帶領各種形式的團隊，共同為提昇臨床基因醫學的國際競爭力及打造臺灣成為全球生物醫學重鎮而努力。

本所研究方向：由基因體學及蛋白體學研究的角度出發，進行以臨床應用為導向之轉譯醫學研究。

15/06/2026

📣7/13演講歡迎踴躍參加📣

[講題]：Mapping the Complexity of Host-Microbe Interactions Through Cross-Kingdom Single-Cell Multi-Omics and Machine Learning

[講者]：林建達助理教授（台大生化科技系）

CV:https://www.mc.ntu.edu.tw/medgenpro/News.action?q_type=-1&q_itemCode=11936

[時間]：2026/7/13 （星期一）上午11：20-12：10

[Hybrid Meeting]:
*地點: 醫學院基醫大樓202講堂
*Webex:

https://ntumc.webex.com/ntumc-tc/j.php?MTID=md111ac2b6f2a5a047e872e87fe0182e3

[摘要]：

Precision medicine seeks to understand how genetic, environmental, and microbial factors collectively shape disease susceptibility and progression. To address this challenge, we have established an integrated systems biology platform that combines cross-kingdom single-cell multi-omics, including host and microbial single-cell profiling, with machine learning approaches to map immune and microbial ecosystems at high resolution. Using murine models of atherosclerosis, we investigated how helminth and microbiota-targeted interventions remodel cardiovascular immunity. Administration of Bacillus subtilis natto NTU-18 reduced aortic lesion burden independently of cholesterol lowering and was associated with expansion of antigen-experienced CD44⁺ CD8⁺ T cells and regulatory T cells, highlighting immune-mediated mechanisms of disease protection. To further dissect host-parasite-microbe interactions, we established bacterial scRNA-seq and indigenous microbiota single-cell sequencing platforms, enabling identification of functional microbial populations associated with helminth-induced atherosclerosis regression. In pancreatic ductal adenocarcinoma （PDAC）, high-dimensional immune profiling by spectral flow cytometry revealed stage-dependent remodeling of more than 70 circulating immune subsets. Integration with machine learning identified CD95 and CD45RA as predictive biomarkers of disease status, demonstrating the utility of computational immunology for precision diagnostics.

To investigate the gut-immune-brain axis, we colonized germ-free LRRK2 G2019S Parkinson’s disease mice with Parabacteroides goldsteinii. Colonization improved motor performance and attenuated neuroinflammation and α-synuclein pathology through coordinated regulation of gut barrier integrity, innate immune signaling, and mucosal T-cell responses. Collectively, these studies demonstrate how cross-kingdom single-cell multi-omics and machine learning can resolve immunological complexity and host–microbe interactions across cardiovascular disease, cancer, and neurodegeneration, providing new opportunities for biomarker discovery and microbiome-informed precision therapeutics.

歡迎踴躍參加！

◎每月精彩演講已放到網路上囉，歡迎大家一起來重溫精彩內容！http://speech.ntu.edu.tw/ntuspeech/Cate/index/id-3

◎歡迎加入演講FB社團，掌握最新演講消息：Medical Genetics & Genomics Monthly Seminar https://www.facebook.com/groups/1109733759041652/

臺大基蛋所　與臺大醫院基因醫學部　敬邀

03/06/2026

📣6/23演講歡迎踴躍參加📣本所在「6/22」皆有演講，歡迎大家一起來參加！

[講題]：Targeting Lysosomal Metabolism in Pancreatic Cancer
（Including a recent study published in Nature (2025; 642:776–784).）

[講者]：Caleb Cheng 鄭嘉樂
MD/PhD Candidate, University of Michigan

[時間]：2026/6/23 上午11：00-12：00

[地點]：基醫大樓202講堂

歡迎踴躍參加！

基蛋所敬邀

28/05/2026

📣6/22演講歡迎踴躍參加📣本所在「6/23」皆有演講，歡迎大家一起來參加！

[講題]：Impacts of Obesity and Diabetes on Skeletal Muscle Mesenchymal Cells: Implications for Structure and Function

[講者]：Prof. Eric Buras

Assistant Professor, Metabolism,

Endocrinology and Diabetes,

University of Michgan, USA

[時間]：2026/6/22 (星期一) 上午11：20-12：10

[地點]: 醫學院基醫大樓202講堂

歡迎踴躍參加！

◎每月精彩演講已放到網路上囉，歡迎大家一起來重溫精彩內容！http://speech.ntu.edu.tw/ntuspeech/Cate/index/id-3

◎歡迎加入演講FB社團，掌握最新演講消息：Medical Genetics & Genomics Monthly Seminar https://www.facebook.com/groups/1109733759041652/

臺大基蛋所與國科會A4基因轉殖鼠核心設施敬邀

13/05/2026

📣6/8演講歡迎踴躍參加📣本所在「6/22」及「6/23」皆有演講，歡迎大家一起來參加！

[講題]：From Biology to Biologics

[講者]：陳佩君董事長暨總經理（永昕生物醫藥股份有限公司）

CV:https://www.mc.ntu.edu.tw/medgenpro/News.action?q_type=-1&q_itemCode=11788

[時間]：2026/6/8 （星期一）上午11：20-12：10

[地點]: 醫學院基醫大樓202講堂

歡迎踴躍參加！

◎每月精彩演講已放到網路上囉，歡迎大家一起來重溫精彩內容！http://speech.ntu.edu.tw/ntuspeech/Cate/index/id-3

◎歡迎加入演講FB社團，掌握最新演講消息：Medical Genetics & Genomics Monthly Seminar https://www.facebook.com/groups/1109733759041652/

臺大基蛋所　與臺大醫院基因醫學部　敬邀

21/04/2026

嗨大家好，
本所陳佑宗所長將於 5/14 邀請目前於 Caltech 從事博士後研究的陳敦元博士至醫學院演講。陳博士的研究聚焦於早期胚胎發育，特別是胚胎在著床（implantation）過程中，如何建立前後軸（anterior-posterior axis）以及胎盤命運的決定，這些都是發育生物學中相當核心且關鍵的問題。

陳博士為台大畢業生，之後於 UC Berkeley 完成博士訓練，目前於 Caltech 進行博士後研究，並與美國 IVF clinic 有合作，研究同時涵蓋基礎機制與人類胚胎相關議題。CV:https://www.dongyuanchen.com/

📌 演講資訊
講題：The Womb Where It Happens: Establishing the Anterior-Posterior Axis and Placental Identity at Implantation

時間：5/14（四）12:15–13:15

地點：基醫202

另外，考量陳博士仍處於相對年輕的學術階段，與大家的距離其實不遠，我們也特別安排了一場輕鬆的交流時間，讓大家可以近距離聊聊他的求學與研究歷程，作為未來規劃的參考。

🍽️ 學生交流（備有餐點，需事先報名）
時間：5/14（四）11:00–12:00（演講前）
地點：1303 幸福講堂
報名連結：
https://docs.google.com/forms/d/e/1FAIpQLSdmTmGlzoGJqvd7ab3s4sO1b3PfCkHB3oPcXavp0Q5Td4cOfw/viewform?usp=header

歡迎大家一起來參加！

14/04/2026

📣5/11演講歡迎踴躍參加📣

[講題]：Imaging and Multiomics Reveal Early Network and Metabolic Dysfunction in Preclinical Models of Alzheimer's Disease

[講者]：陳儀莊所長（中研院生物醫學研究所）

CV:https://www.mc.ntu.edu.tw/medgenpro/News.action?q_type=-1&q_itemCode=11673

[時間]：2026/5/11 (星期一) 上午11：20-12：10

[Hybrid Meeting]:
*地點: 醫學院基醫大樓202講堂
*Webex:

https://ntumc.webex.com/ntumc-tc/j.php?MTID=m8ad5a9f0d3e4bd0dbfc68d56f560fffc

[摘要]：

Alzheimer's disease remains a major unmet medical need, with few effective disease-modifying therapies. To identify early mechanisms and therapeutic opportunities, we use preclinical models of Alzheimer's disease and an integrative approach that combines brain imaging with multiomic analyses. Using diffusion tensor imaging (DTI), we detect early disruption of hippocampal-prefrontal connectivity before overt disease onset. Multiomic analyses further reveal coordinated changes in lipid metabolism and glial support pathways, pointing to impaired network maintenance as a key feature of disease progression. We focus on adenosine signaling as a central regulator. Pharmacological inhibition of ENT1 restores metabolic homeostasis, improves network connectivity, and reduces pathological changes. Together, these findings support a model in which energy imbalance drives neurodegeneration across multiple cell types and highlight new opportunities for disease-modifying intervention.

歡迎踴躍參加！

◎每月精彩演講已放到網路上囉，歡迎大家一起來重溫精彩內容！http://speech.ntu.edu.tw/ntuspeech/Cate/index/id-3

◎歡迎加入演講FB社團，掌握最新演講消息：Medical Genetics & Genomics Monthly Seminar https://www.facebook.com/groups/1109733759041652/

臺大基蛋所與臺大醫院基因醫學部敬邀

30/03/2026

📣4/13演講歡迎踴躍參加📣

[講題]：From Germ Theory to Germ Therapy: Revisit of Koch's Postulates

[講者]：吳明賢院長（臺大醫學院）
CV：https://www.mc.ntu.edu.tw/medgenpro/News.action?q_type=-1&q_itemCode=11553

[時間]：2026/4/13 (星期一) 上午11：20-12：10

[Hybrid Meeting]:
*地點: 醫學院基醫大樓202講堂
*Webex: https://ntumc.webex.com/ntumc-tc/j.php?MTID=m6df73b295528806545ecc717b3b7dded

[摘要]：
荷蘭約雷文虎克(Antoinivan Leeuwenhoek)發明顯微鏡，法國巴斯德(Louis Pasteur)發現微生物與酒精醱酵的關係，促成德國柯霍建立準則(Postulates)及細菌致病學說(Germ Theory)，進而確認一些疾病的產生與微生物的感染有關。我們的研究從幽門桿菌(Helicobacter pylori)出發，探討同一細菌的慢性感染導致慢性胃炎、消化性潰瘍、胃癌及胃淋巴癌的致病機轉，並進行大規模臨床試驗找出抗藥性最低的處方進行除菌治療。
進一步以在社區篩檢幽門桿菌並根除來預防潰瘍及胃癌的發生，証實可減少消化性潰瘍和胃癌發生率與死亡率，並以實証做成國際篩檢幽門桿菌預防胃癌準則及共識的發表。從幽門桿菌出發，我們團隊進一步擴展到腸道微菌(Gut Microbiota)與健康和疾病的研究，發現腸道生態的失衡(Dysbiosis)與健康和慢性疾病及癌症息息相關，有潛力作為未來診斷、治療和預防的標的。腸道生態並不是封閉的小宇宙，而是與宿主基因組成、飲食、代謝和免疫系統緊密交織的巨大網路，未來的研究不應再只是單純分析菌種清單，而是同時整合物種組成、代謝產物、基因功能與互動網路。

歡迎踴躍參加！

◎每月精彩演講已放到網路上囉，歡迎大家一起來重溫精彩內容！http://speech.ntu.edu.tw/ntuspeech/Cate/index/id-3

◎歡迎加入演講FB社團，掌握最新演講消息：Medical Genetics & Genomics Monthly Seminar https://www.facebook.com/groups/1109733759041652/

臺大基蛋所與臺大醫院基因醫學部敬邀

10/03/2026

115學年度基蛋所「博士班一般入學考試」招生開始囉！

✍️報名網址：https://exam.aca.ntu.edu.tw/grad/index.asp

🫶名額：2名

😀竭誠的歡迎你加入本所，與我們一起探尋轉譯醫學的奧妙！！

✍️欲報名者請於3月24日上午9時起，至3月31日晚上24時止索取繳款帳號並繳費，再上網登錄報名資料，於4月1日下午5時前依規定上傳備審資料。

👍本所官網：https://www.mc.ntu.edu.tw/medgenpro/Index.action

02/03/2026

📣3/9演講歡迎踴躍參加📣

[講題]：Practical implementation and challenges of molecular testing in clinical oncology

[講者]：李日翔主任（新竹台大分院腫瘤醫學部）
CV：https://www.mc.ntu.edu.tw/medgenpro/News.action?q_type=-1&q_itemCode=11405

[時間]：2026/3/9　（星期一）上午11：20-12：10

[Hybrid Meeting]:
*地點: 醫學院基醫大樓202講堂
*Webex:
https://ntumc.webex.com/ntumc-tc/j.php?MTID=m3fc08de3f7085816d9072504e14f7e84

[摘要]：
Molecular testing has been the standard in daily oncology practice. Multiple factors shall be taken in to consideration prior to conducting the test, including the timing, the NGS platform, quality and quantity of samples, interpretation of results, drug availability, and the cost of the test to some extent. No individual NGS platform is ideal for all cancer types or even a specific cancer type at difference disease status. Physicians and patients must have idea about what they expect to get before ordering molecular tests. Conducting precision medicine is an ongoing learning process for physicians, patients, and people in the health care system.

歡迎踴躍參加！

◎每月精彩演講已放到網路上囉，歡迎大家一起來重溫精彩內容！http://speech.ntu.edu.tw/ntuspeech/Cate/index/id-3

◎歡迎加入演講FB社團，掌握最新演講消息：Medical Genetics & Genomics Monthly Seminar https://www.facebook.com/groups/1109733759041652/

臺大基蛋所　與臺大醫院基因醫學部　敬邀

19/01/2026

📣2/9演講歡迎踴躍參加📣
👍另在「2/2有兩場重要外賓」演講：https://reurl.cc/W8Zg9O
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[講題]：From Embryos to Pathology: Zebrafish Illuminating the Origins of Human Disease

[講者]：李士傑教授（臺大生科系）

CV：https://www.mc.ntu.edu.tw/medgenpro/News.action?q_type=-1&q_itemCode=11312

[時間]：2026/2/9 (星期一) 上午11：20-12：10

[Hybrid Meeting]:
*地點: 醫學院基醫大樓202講堂
*Webex:

https://ntumc.webex.com/ntumc-tc/j.php?MTID=mb15539d23472f963e132dba3e656e465

[摘要]：

The zebrafish (Danio rerio) has become an increasingly important vertebrate model for investigating the developmental origins and mechanisms of human diseases. Many congenital and early-onset disorders arise from disruptions in embryonic processes such as cell fate specification, tissue morphogenesis, and organ maturation. The zebrafish offers a unique opportunity to directly observe these processes in a living organism, as its embryos develop externally, rapidly, and with optical transparency, allowing real-time visualization of disease-relevant cellular and physiological defects.

Genetically, zebrafish exhibit strong conservation with humans, with most disease-associated pathways and a majority of human genes represented in the zebrafish genome. Modern genome-editing approaches, particularly CRISPR/Cas9, enable efficient generation of loss- and gain-of-function models that recapitulate key features of human diseases. Zebrafish models have been widely applied to study neurodevelopmental disorders, cardiovascular and metabolic diseases, cancer, and rare genetic syndromes, often revealing early pathogenic events that are difficult to capture in mammalian systems.

Beyond genetic diseases, zebrafish are highly suited for functional screening of disease modifiers and therapeutic compounds. Their small size and high reproductive capacity support in vivo drug screening and toxicity testing at scales not feasible in rodents. Importantly, disease phenotypes can be assessed at molecular, cellular, and whole-organism levels within a matter of days.

By integrating embryonic biology with disease modeling, zebrafish provide a powerful platform for identifying pathogenic mechanisms, biomarkers, and therapeutic targets. This model system thus plays a critical role in bridging basic developmental research with translational and precision medicine efforts.

歡迎踴躍參加！

◎每月精彩演講已放到網路上囉，歡迎大家一起來重溫精彩內容！http://speech.ntu.edu.tw/ntuspeech/Cate/index/id-3

◎歡迎加入演講FB社團，掌握最新演講消息：Medical Genetics & Genomics Monthly Seminar https://www.facebook.com/groups/1109733759041652/

臺大基蛋所與臺大醫院基因醫學部敬邀

Address

Zhongshan District

Website

https://www.mc.ntu.edu.tw/medgenpro/Index.action

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