Center for Tropical and Emerging Global Diseases

Center for Tropical and Emerging Global Diseases CTEGD is an interdisciplinary center at UGA established to foster research, education & service related to tropical & emerging infectious diseases.
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The Center for Tropical and Emerging Global Diseases (CTEGD) of the University of Georgia (UGA) is a university-wide, interdisciplinary center established in 1998 to foster research, education and service related to tropical and emerging infectious diseases. Based on a strong foundation of parasitology, immunology, cellular and molecular biology, biochemistry and genetics, CTEGD's 20 faculty are from 8 Departments in 4 Colleges. CTEGD also benefits from the participation of adjunct faculty from the Division of Parasitic Diseases of the Centers for Disease Control and Prevention, and its linkages to the Emory Vaccine Center, both in nearby Atlanta, as well as its relationships with UGA's Faculty of Infectious Diseases, Complex Carbohydrate Research Center and other related programs at UGA. The Center is made up of a wide range of research programs that focus largely on protozoan and metazoan parasites, their hosts and their vectors. Many of these programs have major international, on-site components for both research and training, where the faculty and trainees deal with these global infections and the populations that harbor them. CTEGD's investigators and their laboratories have made major contributions to our understanding of the diseases they study, such as malaria, Chagas disease, toxoplasmosis, cryptosporidiosis, lymphatic filariasis, African sleeping sickness, leishmaniasis and schistosomiasis -diseases of poverty that contribute enormously to global death and disability.

Mission: To pursue cutting edge research on tropical and emerging global diseases and train students in this field.

Operating as usual

We are organizing an Emerging Fellows Symposium for recent and soon-to-graduate students to learn more about post-doc op...
01/21/2021

We are organizing an Emerging Fellows Symposium for recent and soon-to-graduate students to learn more about post-doc opportunities at CTEGD.

We have funded 2-year fellowships for postdocs and many of our labs are looking for postdocs.

Join us for a supportive environment where everyone is excited about all aspects of #parasitology from the molecular to the host and the vector!

Please share and apply.

We are excited to welcome new assistant professor, Dr. Tania Rozario, to CTEGD and UGA.
01/14/2021
Tania Rozario - Center for Tropical and Emerging Global Diseases

We are excited to welcome new assistant professor, Dr. Tania Rozario, to CTEGD and UGA.

The Rozario Lab is interested in how stem cells and germ cells are regulated to enable feats of growth, regeneration, and reproduction in the tapeworm Hymenolepis diminuta

Save the Date! Our annual Molecular Parasitology & Vector Biology Symposium is scheduled for Tuesday, May 4, 2021, and w...
01/12/2021
Symposium - Center for Tropical and Emerging Global Diseases

Save the Date! Our annual Molecular Parasitology & Vector Biology Symposium is scheduled for Tuesday, May 4, 2021, and will be held virtually.

A day-long interactive conference on parasites and host/parasite interactions held at the University of Georgia in Athens, GA.

Are you thinking of applying for one of our Training in Tropical & Emerging Global Diseases fellowships this year? Be su...
01/05/2021
Home - Training in Tropical and Emerging Global Diseases

Are you thinking of applying for one of our Training in Tropical & Emerging Global Diseases fellowships this year? Be sure to check out our new website.

Welcome to the Training in Tropical and Emerging Global Disease Program (TTEGD).

UGA Research
12/02/2020
UGA Research

UGA Research

Four University of Georgia faculty members are reaching a new major milestone in their research careers. Sonia Altizer, John Burke, Diana Downs and Rick Tarleton have been named Fellows of the AAAS - The American Association for the Advancement of Science, an honor bestowed by their peers for “scientifically or socially distinguished efforts to advance science or its applications.”

UGA Franklin College of Arts and Sciences
Odum School of Ecology

Financial contributions from alumni and friends are vital to accomplishing CTEGD’s mission to pursue cutting edge resear...
12/01/2020
Support - Center for Tropical and Emerging Global Diseases

Financial contributions from alumni and friends are vital to accomplishing CTEGD’s mission to pursue cutting edge research in emerging global diseases and train students in this field.

Please consider making a gift to the CTEGD Fund or the Daniel G. Colley Training in Parasitology Fund.

#GivingTuesday

Financial contributions from alumni and friends are vital to accomplishing CTEGD’s mission to pursue cutting edge research in emerging global diseases and train students in this field.

Rick Tarleton discusses the findings of his lab's recently published paper, "A modified drug regimen clears active and d...
11/19/2020
Stronger treatments could cure Chagas disease

Rick Tarleton discusses the findings of his lab's recently published paper, "A modified drug regimen clears active and dormant trypanosomes in mouse models of Chagas disease", in this video.

Researchers in the University of Georgia’s Center for Tropical and Emerging Global Diseases have found that a more intensive, less frequent drug regimen with...

In a new paper published in Transactions of The Royal Society of Tropical Medicine & Hygiene, Pat Lammie and colleagues ...
11/11/2020
Diagnostics and the neglected tropical diseases roadmap: setting the agenda for 2030 - Center for Tropical and Emerging Global Diseases

In a new paper published in Transactions of The Royal Society of Tropical Medicine & Hygiene, Pat Lammie and colleagues describe the purpose and role of the Diagnostics Technical Advisory Group in the context of the challenges facing NTD programmes.

The purpose and role of the Diagnostics Technical Advisory Group are described in the context of the challenges facing NTD programmes.

"Understanding the transmission of vector-borne pathogens across biological scales"
11/10/2020

"Understanding the transmission of vector-borne pathogens across biological scales"

Join us for a remote seminar.
"Understanding the transmission of vector-borne pathogens across biological scales"

New from Chris West & colleagues...Here we verify that TgSPY is the nucleocytoplasmic O-fucosyltransferase (OFT) by 1) c...
11/10/2020
The nucleocytosolic O-fucosyltransferase Spindly affects protein expression and virulence in Toxoplasma gondii - Center for Tropical and Emerging Global Diseases

New from Chris West & colleagues...

Here we verify that TgSPY is the nucleocytoplasmic O-fucosyltransferase (OFT) by 1) complementation with TgSPY-MYC3, 2) its functional dependence on amino acids critical for OGT activity, and 3) its ability to O-fucosylate itself and a model substrate and to specifically hydrolyze GDP-Fuc.

Once considered unusual, nucleocytoplasmic glycosylation is now recognized as a conserved feature of eukaryotes.

Rick Tarleton was recently interviewed by Outbreak News Today.Infectious Disease News Outbreak News Interviews Podcast
11/09/2020
Chagas disease treatment research with Rick Tarleton, PhD - Outbreak News Today

Rick Tarleton was recently interviewed by Outbreak News Today.

Infectious Disease News Outbreak News Interviews Podcast

Chagas disease is a potentially life-threatening parasitic disease that affects up to 300,000 people in the United States and millions in South America. The current treatment regimen is–oral benznidazole in smaller twice-daily doses over 2 months My guest today and his colleagues say high weekly d...

UGA Infectious Diseases Department
11/07/2020

UGA Infectious Diseases Department

Join us for a remote seminar.
UGA Franklin College of Arts and Sciences UGA Biochemistry and Molecular Biology

The Kissinger Lab is interested in parasite genomics and the biology of genome evolution. How do genomes evolve? Can we ...
11/03/2020
Jessica Kissinger - Center for Tropical and Emerging Global Diseases

The Kissinger Lab is interested in parasite genomics and the biology of genome evolution. How do genomes evolve? Can we trace gene order, identify and determine the fate of horizontally transferred genes (as well as any existing endogenous orthologs) and identify genes that are phylogenetically restricted? The answers to these questions are important because of the insight they provide into parasite biology and the identification of potential drug targets. Their research focuses on, but is not limited to, Apicomplexan parasites.

Research interest: Comparative genomic approaches to address issues relevant to the evolution and biology of the Apicomplexa.

11/02/2020
Openshot Video Small Con Intro Corrected2 1

“With light sheet fluorescence microscopy, you have a broad view of potentially any tissue in the mouse that allows for dependable assessment of parasite load and persistence,” said Tarleton. “It gives you an incredible view of the infection.”

A new study led by Juan Bustamante and Fernando Sanchez-Valdez in the Tarleton Research Group found that giving as littl...
10/29/2020
Stronger treatments could cure Chagas disease

A new study led by Juan Bustamante and Fernando Sanchez-Valdez in the Tarleton Research Group found that giving as little as two-and-a-half times the typical daily dose of benznidazole, once per week for 30 weeks, completely cleared the infection.

Research shows stronger but less frequent drug doses could be key.

The Center for Tropical and Emerging Global Diseases is made up of a wide range of research programs that focus largely ...
10/28/2020
Who We Are - Center for Tropical and Emerging Global Diseases

The Center for Tropical and Emerging Global Diseases is made up of a wide range of research programs that focus largely on protozoan and metazoan parasites, their hosts and their vectors. Many of these programs have major international, on-site components for both research and training, where the faculty and trainees deal with these global infections and the populations that harbor them. CTEGD’s investigators and their laboratories have made major contributions to our understanding of the diseases they study – diseases of poverty that contribute enormously to global death, disability and instability.

The Center for Tropical and Emerging Global Diseases is an interdisciplinary center established in 1998 to foster research, education and service.

Belen Cassera's laboratory uses multidisciplinary approaches including biochemistry, cellular and molecular biology to s...
10/27/2020
M. Belen Cassera - Center for Tropical and Emerging Global Diseases

Belen Cassera's laboratory uses multidisciplinary approaches including biochemistry, cellular and molecular biology to study changes in the metabolism of the malaria parasite throughout its life cycle and to reveal how metabolites are transformed into products through a precise and, sometimes, unique way among organisms that they can later exploit to develop safer treatments.

Research interest: Functional metabolomics applied to eukaryotic pathogens and antimalarial drug discovery from natural products and synthetic sources.

New from the Docampo Lab:Some of the signaling pathways and second messengers potentially involved in the response to th...
10/12/2020
Signaling pathways involved in environmental sensing in Trypanosoma cruzi - Center for Tropical and Emerging Global Diseases

New from the Docampo Lab:

Some of the signaling pathways and second messengers potentially involved in the response to these changes have been elucidated in recent years and are the subject of this review.

Some of the signaling pathways and second messengers potentially involved in the response to these changes have been elucidated in recent years and will be the subject of this review.

New from Chris West & colleagues"With an emphasis on emerging areas of protist glycobiology, here we offer an overview o...
10/01/2020
Glycomics, Glycoproteomics and Glycogenomics: an Inter-Taxa Evolutionary Perspective - Center for Tropical and Emerging Global Diseases

New from Chris West & colleagues

"With an emphasis on emerging areas of protist glycobiology, here we offer an overview of glycan diversity and evolution, to promote future access to this treasure trove of glycobiological processes."

An overview of glycan diversity and evolution, to promote future access to this treasure trove of glycobiological processes.

Karla Marquez Nogueras will be defending her dissertation, "Calcium signaling pathway in Toxoplasma gondii", on Oct. 6. ...
09/30/2020
Trainee Spotlight: Karla Márquez Nogueras - Center for Tropical and Emerging Global Diseases

Karla Marquez Nogueras will be defending her dissertation, "Calcium signaling pathway in Toxoplasma gondii", on Oct. 6. Learn more about her and her research focus in this spotlight from 2018.

NIH T32 Trainee Karla M. Márquez Nogueras is in her 4th year of graduate training in Silvia Moreno‘s laboratory. Before entering the Ph.D. program at UGA, she taught for a semester at Turabo University in Puerto Rico, teaching undergraduate courses like Introduction to Microbiology and Human...

New paper from the Kyle Lab:The results of these studies demonstrate the utility of phenotypic screens for discovery of ...
09/25/2020
Discovery of repurposing drug candidates for the treatment of diseases caused by pathogenic free-living amoebae - Center for Tropical and Emerging Global Diseases

New paper from the Kyle Lab:

The results of these studies demonstrate the utility of phenotypic screens for discovery of new drugs for pathogenic free-living amoebae, including Acanthamoeba for the first time.

This report addresses the discovery of new active drugs with potential for repurposing, multiple new drug classes that inhibit pathogenic FLA, and numerous putative drug targets that can be used as tools for further investigation and structure-based drug design.

Dennis Kyle, director of CTEGD, is the GRA Eminent Scholar in Antiparasitic Drug Discovery. His endowment enables him to...
09/23/2020
Dennis Kyle: Finding Solutions for Deadly Diseases - UGA Today

Dennis Kyle, director of CTEGD, is the GRA Eminent Scholar in Antiparasitic Drug Discovery. His endowment enables him to run a 16-person staff of student researchers, postdocs, and research scientists. Their research projects focus on malaria and Naegleria fowleri.

The Amoeba Summit in Orlando last year is where the importance of her work on drug discovery for deadly amoebae really hit home for Cassiopeia Russell. It was there she learned the story of an 11-year-old boy who had gone on a family vacation to Costa Rica and was having a great time going down […...

New paper from Chris West and colleagues:To gain insight into the factors underlying different PHD substrates and proper...
09/22/2020
Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii - Center for Tropical and Emerging Global Diseases

New paper from Chris West and colleagues:

To gain insight into the factors underlying different PHD substrates and properties, we carried out biochemical and biophysical studies on PHD homologues from the slime mold, Dictyostelium discoideum, and the protozoan parasite, Toxoplasma gondii, both lacking HIF.

The combined results support the proposal that PHD homologues have evolved kinetic and structural features suited to their specific sensing roles.

New from the Docampo lab!Here, we present evidence that TcIP3R is a Ca2+ release channel gated by IP3 when expressed in ...
09/21/2020
IP 3 receptor-mediated Ca 2+ release from acidocalcisomes regulates mitochondrial bioenergetics and prevents autophagy in Trypanosoma cruzi - Center for Tropical and Emerging Global Diseases

New from the Docampo lab!

Here, we present evidence that TcIP3R is a Ca2+ release channel gated by IP3 when expressed in DT40 cells knockout for all vertebrate IP3 receptors, and is required for Ca2+ uptake by T. cruzi mitochondria, regulating pyruvate dehydrogenase dephosphorylation and mitochondrial O2 consumption, and preventing autophagy.

The results suggest a modulatory activity of TcIP3R-mediated acidocalcisome Ca2+ release on cell bioenergetics in T. cruzi.

New from Adrian Wolstenholme & colleagues."The recent identification of isolates of D. immitis with confirmed resistance...
09/18/2020
Comparative sequences of the Wolbachia genomes of drug-sensitive and resistant isolates of Dirofilaria immitis - Center for Tropical and Emerging Global Diseases

New from Adrian Wolstenholme & colleagues.

"The recent identification of isolates of D. immitis with confirmed resistance to the macrocyclic lactone preventatives presents an opportunity for comparative genomic studies using these isolates, and examining the genetic diversity within and between them."

Phylogenetic analysis suggested that the endosymbionts of the drug-susceptible isolates are more closely related to each other than to those from any of the resistant parasites.

Address

500 DW Brooks Dr
Athens, GA
30602

General information

CTEGD has two affiliated Core facilities that are available to researchers at UGA and external researchers in the surrounding scientific community. The Flow Cytometry Facility provides access to state-of-the-art flow cytometry analyzers including a Luminex multiplexing instrument and flow cytometer cell sorter. http://ctegdcytometry.ovpr.uga.edu/ The Biomedical Microscopy Core provides expertise and training to assist researchers. The facility houses deconvolution, confocal, and super resolution microscopes. http://bmc.uga.edu/

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Committed to Improving Global Health

The Center for Tropical and Emerging Global Diseases (CTEGD) of the University of Georgia (UGA) is a university-wide, interdisciplinary center established in 1998 to foster research, education and service related to tropical and emerging infectious diseases. Based on a strong foundation of parasitology, immunology, cellular and molecular biology, biochemistry and genetics, CTEGD's 23 faculty are from 8 Departments in 4 Colleges. Learn more about our faculty: https://ctegd.uga.edu/about/directory/ CTEGD also benefits from the participation of adjunct faculty from the Division of Parasitic Diseases of the Centers for Disease Control and Prevention, and its linkages to the Emory Vaccine Center, both in nearby Atlanta, as well as its relationships with UGA's Faculty of Infectious Diseases, Complex Carbohydrate Research Center and other related programs at UGA. The Center is made up of a wide range of research programs that focus largely on protozoan and metazoan parasites, their hosts and their vectors. Many of these programs have major international, on-site components for both research and training, where the faculty and trainees deal with these global infections and the populations that harbor them. CTEGD's investigators and their laboratories have made major contributions to our understanding of the diseases they study, such as malaria, Chagas disease, toxoplasmosis, cryptosporidiosis, lymphatic filariasis, African sleeping sickness, leishmaniasis and schistosomiasis -diseases of poverty that contribute enormously to global death and disability.

We are committed to pursue cutting edge research on tropical and emerging global disease, train students in this field, and effectively tackle global diseases of poverty.

With your support, our researchers and students can work together on some of the most important causes of human suffering around the world, including malaria, schistosomiasis, African sleeping sickness, Chagas disease, cryptosporidiosis, toxoplasmosis, leishmaniasis, and filariasis. Give today: https://ctegd.uga.edu/give/

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