10/06/2026
UC Berkeley researchers have created a new genomic language AI model, called GPN-Star, that far outpaces its competitors at identifying important genetic variants that contribute to inherited traits, including those that lead to disease.
In the new study – led by Yun S. Song, professor of computer science and statistics at UC Berkeley – the team found that models trained at different evolutionary timescales were better at interpreting different kinds of genetic variants. Because the model requires minimal resources to train, the researchers hope that the model will help other teams around the world modify, adapt and improve upon their work, accelerating our understanding of genetics in humans and other species. The research was published Sept. 9 in the journal Nature.
“We hope our work will help drive biological discovery,” said Song, director of the Center for Computational Biology, UC Berkeley, co-director of the UC Berkeley-UCSF Bakar Computational Biomedicine Initiative, and an investigator at the Innovative Genomics Institute. “People have developed really creative tools for assaying the impact of genetic variants, but they cannot experimentally test every single variant in the genome. We believe our predictions will help to prioritize the experiments that could have the greatest impact on human health.”
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UC Berkeley Department of Statistics | Berkeley Engineering