There will be a seminar next Monday, April 25th, in the Krasnow Lecture Room 229. : A. Rory McQuiston (Department of Anatomy and Neurobiology, VCU) will be presenting a seminar titled, "Forebrain networks involved in theta rhythm generation." Refreshments will be served at 3:30 pm in the lobby, followed by the talk at 4:00 pm. See the Abstract below for more detail:
Theta rhythm in the hippocampus is thought to play a crucial role in the formation of long term memories and has been correlated with attentive behaviors, REM sleep, arousal, and sensorimotor integration. There is more than one mechanism responsible for generating theta rhythm; however, theta rhythm generation is dependent on an intact functional medial septum/diagonal band of Broca (MS/DBB) complex. In this seminar I will discuss studies from our lab examining cholinergic and GABAergic inputs from the MS/DBB to hippocampal CA1 using optogenetics and whole cell patch clamping in brain slice preparations. The roles of cholinergic and GABAergic inputs in controlling hippocampal function will be discussed.