03/16/2026
Washington, D.C. — March 2026
Researchers from the Stewart Laboratory presented their latest scientific findings at the American Society for Biochemistry and Molecular Biology (ASBMB) Annual Meeting in Washington, D.C. The laboratory's work focuses on BRCA1, a critical tumor suppressor protein whose mutations are linked to hereditary breast and ovarian cancer.
Three members of the laboratory — Dr. Mikaela Stewart, Meagan McMann (MS 2026, PhD 2029), and Jamison Speed (MS 2026) — each presented original research at the conference. Jamison's presentation examined how inherited mutations that disrupt protein-protein interactions can impair the ability of BRCA1 and its partner protein PALB2 to carry out DNA repair to prevent tumor development. Meagan's research focused on the model organism C. elegans. Her findings suggest that BRCA1's E3 ligase enzymatic function plays an essential role in both DNA repair and gene regulation. Dr. Stewart presented two projects. The first explored how small molecules can be used to interfere with the BRCA1/PALB2 protein interaction, mimicking the effect of hereditary mutations in patients whose breast cancer is not inherited. This approach could expand the range of available treatments for a broader population of patients. Her second presentation demonstrated the effectiveness of using a case study to teach empathy along with metabolic disease and cell signaling in the classroom. Coauthors of the presentations included Stewart Lab undergraduate students Madison Adams (Biology BS 2026), Styrling Murray (Biology BS 2026, Lucy McCollum (Biology BS 2025), and Nathalie Carlon (Biology BS 2025).
For more information about the Stewart Laboratory and its research, please contact [email protected].