10/08/2026
Ali Irhabi, a sophomore finance major with minors in chemistry and biology, was one of ten fellows selected nationally to participate in the NIH-funded Cardiovascular Undergraduate Research Fellowship (UH-CURE) at the University of Houston this past summer. Working under the mentorship of Dr. Robert J. Schwartz and Dr. Dinakar Iyer, Ali’s research focuses on a major challenge in heart disease: the heart has very little ability to replace cells lost after injury. His lab developed engineered versions of two proteins, STEMIN and YAP5SA, that can help heart cells enter a more regenerative state. The lab also found that treated heart cells release tiny packages called exosomes, which carry protective signals to surrounding cells and can help prevent cell death.
Ali’s project tests whether these exosomes can protect human heart cells from different forms of injury, including damage caused by certain chemotherapy drugs. He also studies the cells in a 3D rotating bioreactor based on NASA technology, creating a model that more closely resembles how cells behave in the body. His preliminary results have been promising, and the long-term goal is to explore whether these exosomes could one day provide a simpler, less invasive way to protect damaged hearts, potentially through a transfusion-based therapy.
Ali was selected by the American Heart Association (AHA) as a 2026 Institutional Undergraduate Student Trainee and presented his research at the AHA BCVS National Conference in Boston. While in Boston, he delivered a flash talk at Harvard Medical School/Boston Children’s Hospital, and his abstract underwent peer review through AHA. He also gave an oral presentation to the UH College of Pharmacy and delivered oral and poster presentations at the Pharmacological and Pharmaceutical Sciences Research Symposium.
Ali continues to build on the project, taking greater ownership of his research and growing as an independent researcher. He has had the opportunity to work alongside world-class researchers in cardiovascular and translational medicine as he pursues his interest in becoming a physician-scientist. 💡 🔍
UH Bauer College
UH College of Natural Sciences and Mathematics