09/02/2026
New research from the Marshall University Joan C. Edwards School of Medicine provides insight into how binge alcohol exposure during adolescence may cause lasting changes in brain function that persist into adulthood.
“Human studies have shown that adolescent binge drinking can drive long-term impairment in cognition and worsen mental health outcomes that are risk factors for alcohol and substance use disorders,” said Mary-Louise Risher, PhD, associate professor at the School of Medicine.
“Growing evidence in recent years has highlighted a promising new role of astrocytes in the modulation of synaptic activity and behavioral outcomes,” said Olivia Coulter, first author of the paper and doctoral candidate at the Joan C. Edwards School of Medicine. “These cells contribute to the regulation of neurona function, influencing complex behaviors. Astrocytes are now being recognized as potential therapeutic targets for rescuing deficits associated with brain injury and mental health disorders. This work is an important step towards developing new astrocyte-targeted strategies to improve brain health.”
🗞️ Learn more: bit.ly/4x5irpn