07/15/2026
Congratulations to the DeSmet Lab on publishing "Targeted Protein Degradation Strategies in DNA Virus Research" in Viruses, a peer-reviewed open-access journal of virology, published online monthly by the Multidisciplinary Digital Publishing Institute.
In the article, they explored a technology called PROTACs, which act like molecular disposal tags. Viruses depend on proteins, both their own and those inside cells, to reproduce and remain in the body. PROTACs direct specific proteins to the cell’s natural protein-degradation system so they can be broken down.
They review how scientists can use this technology to better understand how DNA viruses, including human papillomaviruses and herpesviruses, cause infection and persist in the body. We also suggest new viral proteins that could be studied or targeted using PROTACs.
This approach may eventually contribute to new antiviral treatments that selectively remove proteins viruses need to survive.
Well done, Dr. Marsha DeSmet, Michael Lam '26, MS, OMS-1, Ethan Thornburg '26, MS, OMS-1, and Chayah Hill '26, MS!
Read the article at https://hubs.la/Q04pD0J50.