Clinical Pathology, College of Veterinary Medicine, Cornell University

Clinical Pathology, College of Veterinary Medicine, Cornell University The Clinical Pathology team at Cornell University is dedicated to disseminating information on-line via our website, Facebook, Twitter and Instragram
(25)

Operating as usual

Starch crystals in urine🔬The first image is a standard wet preparation of a urine sediment showing large refractile  tri...
05/30/2021

Starch crystals in urine
🔬The first image is a standard wet preparation of a urine sediment showing large refractile triangular to ovoid starch crystals with a characteristic central three pointed indentation. You often have to focus up-and-down to see these indentations.
🔬The second image is a modified Wright’s-stained line smear of the same sediment, showing that the crystals become colorless with faint outlines in this stain, but you can still see the central indentations.
🔬These crystals are a contaminant, usually from glove powder, but are seen frequently these days with less use of powdered latex gloves.
#veterinarymedicine #veterinary #cornellvet #cornell #cornelluniversity #clinicalpathology #cornellveterinary #clinpath #veterinaryclinicalpathology #vetclinpath #pathology #veterinarypathology #vetpath #urinalysis #starchcrystal #veterinarytechnician #veterinarystudent

Inadvertent aspiration of the cerebellum (same case as previous post): A higher power magnification of the body of the p...
05/23/2021

Inadvertent aspiration of the cerebellum (same case as previous post): A higher power magnification of the body of the purkinje cell (arrow) and a capillary (arrowhead). The cells are embedded in purple feathery material (neuropil).
🔬Modified Wright’s stain, 50x objective
#cornell #cornelluniversity #cornellvet #cornellveterinary #clinicalpathology #clinpath #cytology #cytopathology #cerebellum #brain #neuron #capillary #veterinarycytology #veterinarymedicine #veterinaryclinicalpathology #veterinarypathology #vetpath #vetclinpath #veterinary #pathology

Inadvertent aspiration of the cerebellum (same case as previous post): A higher power magnification of the body of the purkinje cell (arrow) and a capillary (arrowhead). The cells are embedded in purple feathery material (neuropil).
🔬Modified Wright’s stain, 50x objective
#cornell #cornelluniversity #cornellvet #cornellveterinary #clinicalpathology #clinpath #cytology #cytopathology #cerebellum #brain #neuron #capillary #veterinarycytology #veterinarymedicine #veterinaryclinicalpathology #veterinarypathology #vetpath #vetclinpath #veterinary #pathology

Inadvertent aspiration of cerebellum during a post-mortem cerebrospinal fluid tap in a calf: The smears contained thin c...
05/23/2021

Inadvertent aspiration of cerebellum during a post-mortem cerebrospinal fluid tap in a calf: The smears contained thin capillaries (arrowhead) and purkinje cells with pear-shaped bodies and long thin axons (arrows). Not often we get to see smears of normal brain tissue🧠!
🔬modified Wright’s stain, 10x objective
#cornell #cornelluniversity #cornellvet #cornellvetmed #cornellveterinary #veterinarycytology #veterinarymedicine #veterinaryclinicalpathology #veterinary #vetclinpath #clinicalpathology #clinpath #cytology #cytopathology #pathology #veterinarypathology #cerebellum #calf

Inadvertent aspiration of cerebellum during a post-mortem cerebrospinal fluid tap in a calf: The smears contained thin capillaries (arrowhead) and purkinje cells with pear-shaped bodies and long thin axons (arrows). Not often we get to see smears of normal brain tissue🧠!
🔬modified Wright’s stain, 10x objective
#cornell #cornelluniversity #cornellvet #cornellvetmed #cornellveterinary #veterinarycytology #veterinarymedicine #veterinaryclinicalpathology #veterinary #vetclinpath #clinicalpathology #clinpath #cytology #cytopathology #pathology #veterinarypathology #cerebellum #calf

Rhodococcus equi in a foal🔬 The organism, which is a facultative aerobe found in soil, usually infects foals less than s...
05/15/2021

Rhodococcus equi in a foal
🔬 The organism, which is a facultative aerobe found in soil, usually infects foals less than six months of age and causes suppurative to mixed (neutrophils, macrophages) inflammation in the lungs (bronchopneumonia).
🔬First image: The organism is a pleomorphic coccobacillus found in groups, phagocytized within degenerate neutrophils (arrow) and extracellularly (arrowhead) in this direct smear of a tracheal wash from a foal. Modified Wright’s stain
🔬Second image: On a Gram stain, the bacterium is gram positive (arrow) but decolorizes rapidly.
🔬The organism can spread outside the lungs causing extrapulmonary abscesses, such as in abdominal lymph nodes, typhlitis, synovitis and osteomyelitis.
🔬Infections in the skin, lungs and thorax can also occur in other species, such as dogs and barn cats, but are rare.
#cornell #cornelluniversity #cornellvet #cornellveterinary #cornellvetmed #veterinarymedicine #veterinary #veterinaryclinicalpathology #veterinarypathology #pathology #clinicalpathology #clinpath #cytology #cytopathology #trachealwash #foal #horse #rhodococcusequi #bacteria #lungs

Eosinophilia and Babesia vulpes in a fox 🦊🔬 First image: The fox had a mild regenerative anemia and a leukocytosis consi...
05/08/2021

Eosinophilia and Babesia vulpes in a fox 🦊
🔬 First image: The fox had a mild regenerative anemia and a leukocytosis consisting of a neutrophilia and an eosinophilia (arrows).
🔬Second image: Low numbers of tiny ring-shaped organisms (around 1-2 µm) were seen in a few red blood cells (arrow). The organism is consistent with Babesia vulpes, also known as Theileria annae. This protozoal parasite is known to be endemic in foxes and may not be responsible for the regenerative anemia seen in this particular fox. The organism is also unlikely to be responsible for the eosinophilia. It was more likely that the fox had a concurrent ecto- or endoparasite that was inciting the eosinophilia. The cause of the anemia (hemorrhage or hemolysis) was not ascertained in this wild fox. The neutrophilia supported a concurrent inflammatory response, although an endogenous corticosteroid (stress) component cannot be excluded.
🔬Modified Wright’s stain
#cornell #cornelluniversity #cornellvet #cornellveterinary #veterinarymedicine #veterinaryclinicalpathology #vetclinpath #veterinarypathology #vetpath #vetmed #clinicalpathology #clinpath #path #pathology #hematology #hematopathology #fox #eosinophils #babesia #theileria #parasites

Our latest diagnostic challenge is now live! It is an aspirate from a retrobulbar mass in a dog. Check it out at eclinpa...
04/29/2021

Our latest diagnostic challenge is now live! It is an aspirate from a retrobulbar mass in a dog. Check it out at eclinpath.com: https://eclinpath.com/case-of-the-month/. 😀
#cornell #cornelluniversity #cornellvet #cornellveterinary #veterinarymedicine #veterinary #veterinaryclinicalpathology #vetclinpath #veterinarypathology #vetpath #clinicalpathology #clinpath #cytology #cytopathology #cancer #dog #meningioma #fnapath #eye #pathology

Immune mediated anemia and thrombocytopenia in a calf🐄The calf presented with a hematocrit of 14% and a platelet count o...
04/25/2021

Immune mediated anemia and thrombocytopenia in a calf
🐄The calf presented with a hematocrit of 14% and a platelet count of 5000 per microliter (severe anemia and thrombocytopenia).
🔬On smear examination, there was evidence of regenerative response, as seen by the polychromatophils (long arrows). Moderate numbers of small red blood cells, presumptive spherocytes, were also seen (short arrows). The two leukocytes are a monocyte (arrowhead) and an eosinophil (lower cell) (modified Wright’s stain, 100x objective). 💊The cytopenias in the calf responded to immunosuppressive treatment with corticosteroids.
#calf #cattle #cornell #cornelluniversity #cornellvet #cornellveterinary #clinicalpathology #clinpath #veterinarymedicine #veterinary #vetmed #veterinaryclinicalpathology #vetclinpath #veterinarypathology #vetpathology #pathology #hematology #hematopathology #immunemediatedhemolyticanemia #immunemediatedthrombocytopenia #thrombocytopenia #anemia

Immune mediated anemia and thrombocytopenia in a calf
🐄The calf presented with a hematocrit of 14% and a platelet count of 5000 per microliter (severe anemia and thrombocytopenia).
🔬On smear examination, there was evidence of regenerative response, as seen by the polychromatophils (long arrows). Moderate numbers of small red blood cells, presumptive spherocytes, were also seen (short arrows). The two leukocytes are a monocyte (arrowhead) and an eosinophil (lower cell) (modified Wright’s stain, 100x objective). 💊The cytopenias in the calf responded to immunosuppressive treatment with corticosteroids.
#calf #cattle #cornell #cornelluniversity #cornellvet #cornellveterinary #clinicalpathology #clinpath #veterinarymedicine #veterinary #vetmed #veterinaryclinicalpathology #vetclinpath #veterinarypathology #vetpathology #pathology #hematology #hematopathology #immunemediatedhemolyticanemia #immunemediatedthrombocytopenia #thrombocytopenia #anemia

Malignant melanoma on the maxilla of a dog🔬The round to spindled cells formed loosely cohesive groupings (long arrow) an...
04/17/2021

Malignant melanoma on the maxilla of a dog
🔬The round to spindled cells formed loosely cohesive groupings (long arrow) and had pleomorphic nuclei with small to moderate amounts of light blue cytoplasm. Nuclear chromatin was fine and a few cells had large prominent nucleoli. There were several mitotic figures (short arrow) and individual cells were undergo cell death (arrowhead) (first image)
🔬The second image shows an indented to monocytoid nucleus in a tumor cell (arrow). Rare cells contained small amounts of melanin in their cytoplasm.
🔬Both images: Modified Wright’s stain
#cornell #cornelluniversity #cornellvet #cornellveterinary #veterinarymedicine #veterinary #veterinaryclinicalpathology #vetclinpath #veterinarypathology #vetpath #clinicalpathology #clinpath #pathology #cytology #cytopathology #cytopath #melanoma #malignantmelanoma #dog #cancer

Copper poisoning in a sheep: The sheep had a hemolytic anemia that was regenerative, as seen by the polychromatophils (l...
04/11/2021

Copper poisoning in a sheep: The sheep had a hemolytic anemia that was regenerative, as seen by the polychromatophils (long arrow, first image). There was an intravascular component to the anemia, with numerous ghost cells containing Heinz bodies in the background and concurrent hemoglobinemia. Heinz bodies are also present in the intact red blood cells. Several red blood cells contain thin linear to round cytoplasmic inclusions, compatible with iron (short arrows, first image) (modified Wright’s stain). The latter red blood cells are called siderocytes. The second image shows the siderotic inclusions in the red blood cells with a Prussian blue stain, which stains iron blue (arrows).
🔬Ghost red blood cells are partially lysed cells, with membrane outlines and colorless cytoplasm or cytoplasm that has a tinge of red from remnants of hemoglobin. They have mostly released their cytoplasmic hemoglobin due to membrane rupture. In this case, the ghost cells are due to intravascular hemolysis (lysing within vessels in the patient) due to oxidative membrane damage, but they can also be seen as an artifact of smear preparation or reflect in vitro or artifactual hemolysis, in which red blood cells rupture during blood sample collection or in the tube with storage (i.e. not rupturing in the vessels of the patient)
🔬Heinz bodies indicate oxidative damage to the hemoglobin molecule within red blood cells.
🔬Siderocytes in this case are attributed to increased red blood cell turnover, i.e. the hemolytic anemia.
#cornell #cornelluniversity #cornellvet #cornellveterinary #veterinarymedicine #veterinary #veterinaryclinicalpathology #vetclinpath #veterinarypathology #vetpath #pathology #clinicalpathology #hematology #hematopathology #hemepath #sheep #copperpoisoning #heinzbodies #oxidant #siderocyte #ghostcell

Aspirate of a lytic scapular mass in a five year old dog: The mass consisted of many discrete round cells with eccentric...
04/04/2021

Aspirate of a lytic scapular mass in a five year old dog: The mass consisted of many discrete round cells with eccentric nuclei, medium to dark blue cytoplasm, and a perinuclear clear zone (arrows, first image). These are features of plasma cells. A few binucleated cells were seen (arrow, second image). The cells showed robust mitotic activity, with aberrant mitoses (arrows, third image). A cytologic diagnosis of multiple myeloma was made. The dog also had a lytic lesion in the 6th thoracic vertebra. #cornellvet #cornell #cornelluniversity #cornellveterinary #veterinarycytology #veterinarymedicine #veterinary #veterinaryclinicalpathology #veterinarypathology #vetclinpath #vetpath #pathology #clinicalpathology #clinpath #cytology #cytopath #cytopathology #dog #cancer #plasmacell #multiplemyeloma

A macrophage with an apparent bile cast (and erythrocyte) within the cytoplasm (arrowhead). This unusual finding was obs...
03/28/2021

A macrophage with an apparent bile cast (and erythrocyte) within the cytoplasm (arrowhead). This unusual finding was observed in an aspirate of a liver of a dog, which had a sarcoma and severe cholestasis (high total and direct bilirubin). The bile cast was attributed to the cholestasis and the erythrophage likely reflected concurrent hemorrhage.
🔬Bile casts are normally seen intercalated within clusters of hepatocytes versus within macrophages. Bile casts within a liver aspirate indicate cholestasis.
🔬Erythrophagocytic macrophages in a liver aspirate could indicate normal removal of effete red blood cells, premature removal of circulating erythrocytes (extravascular hemolysis), or localized hemorrhage.
#cornellvet #cornell #cornelluniversity #cornellveterinary #veterinarymedicine #veterinaryclinicalpathology #vetclinpath #veterinary #clinicalpathology #clinpath #veterinarypathology #vetpath #pathology #cytopathology #cytopath #cytology#liver #macrophage #bilecasts #dog

A macrophage with an apparent bile cast (and erythrocyte) within the cytoplasm (arrowhead). This unusual finding was observed in an aspirate of a liver of a dog, which had a sarcoma and severe cholestasis (high total and direct bilirubin). The bile cast was attributed to the cholestasis and the erythrophage likely reflected concurrent hemorrhage.
🔬Bile casts are normally seen intercalated within clusters of hepatocytes versus within macrophages. Bile casts within a liver aspirate indicate cholestasis.
🔬Erythrophagocytic macrophages in a liver aspirate could indicate normal removal of effete red blood cells, premature removal of circulating erythrocytes (extravascular hemolysis), or localized hemorrhage.
#cornellvet #cornell #cornelluniversity #cornellveterinary #veterinarymedicine #veterinaryclinicalpathology #vetclinpath #veterinary #clinicalpathology #clinpath #veterinarypathology #vetpath #pathology #cytopathology #cytopath #cytology#liver #macrophage #bilecasts #dog

Lymphoma in pericardial fluid from a cat: Large neoplastic lymphocytes were seen in the fluid (arrow), which had a nucle...
03/22/2021

Lymphoma in pericardial fluid from a cat: Large neoplastic lymphocytes were seen in the fluid (arrow), which had a nucleated cell count of 8,900/uL and total protein of 5.3 g/dL. There was also evidence of hemorrhage as seen by the macrophages phagocytizing red blood cells (arrowhead). The pericardium is an uncommon site for a primary lymphoma.
🔬Wright’s stain
🔬#cornell #cornelluniversity #cornellvet #cornellveterinary #cornellvetmed #veterinarymedicine #veterinary #clinicalpathology #clinpath #veterinaryclinicalpathology #vetclinpath #veterinarypathology #vetpath #cytopathology #cytology #pathology #cats #pericardialeffusion #lymphoma #cancer

Lymphoma in pericardial fluid from a cat: Large neoplastic lymphocytes were seen in the fluid (arrow), which had a nucleated cell count of 8,900/uL and total protein of 5.3 g/dL. There was also evidence of hemorrhage as seen by the macrophages phagocytizing red blood cells (arrowhead). The pericardium is an uncommon site for a primary lymphoma.
🔬Wright’s stain
🔬#cornell #cornelluniversity #cornellvet #cornellveterinary #cornellvetmed #veterinarymedicine #veterinary #clinicalpathology #clinpath #veterinaryclinicalpathology #vetclinpath #veterinarypathology #vetpath #cytopathology #cytology #pathology #cats #pericardialeffusion #lymphoma #cancer

A granular lymphocyte with reactive features (increased amount of cytoplasm, arrow), two other lymphocytes (both reactiv...
03/15/2021

A granular lymphocyte with reactive features (increased amount of cytoplasm, arrow), two other lymphocytes (both reactive with bluer cytoplasm than normal and the cell on the right is large) and a cell with a Leukocytozoon gamont (upper middle cell), and several polychromatophilic red blood cells in a blood smear from a hawk. Granular lymphocytes can be seen in low numbers in normal birds; in this bird it was considered part of a reactive response (to antigenic stimulation). Leukocytozoon can be an incidental finding. #cornell #cornelluniversity #cornellvet #cornellveterinary #veterinarymedicine #veterinaryclinicalpathology #veterinarypathology #vetclinpath #vetpath #clinicalpathology #clinpath #pathology #veterinary #bird #leukocytozoon #granularlymphocytes #reactivelymphocyte #hematopathology #hemepath #hematology

A granular lymphocyte with reactive features (increased amount of cytoplasm, arrow), two other lymphocytes (both reactive with bluer cytoplasm than normal and the cell on the right is large) and a cell with a Leukocytozoon gamont (upper middle cell), and several polychromatophilic red blood cells in a blood smear from a hawk. Granular lymphocytes can be seen in low numbers in normal birds; in this bird it was considered part of a reactive response (to antigenic stimulation). Leukocytozoon can be an incidental finding. #cornell #cornelluniversity #cornellvet #cornellveterinary #veterinarymedicine #veterinaryclinicalpathology #veterinarypathology #vetclinpath #vetpath #clinicalpathology #clinpath #pathology #veterinary #bird #leukocytozoon #granularlymphocytes #reactivelymphocyte #hematopathology #hemepath #hematology

Address

Upper Tower Road
Ithaca, NY
14850

Alerts

Be the first to know and let us send you an email when Clinical Pathology, College of Veterinary Medicine, Cornell University posts news and promotions. Your email address will not be used for any other purpose, and you can unsubscribe at any time.

Nearby universities


Comments

Dear colleagues. I need informations about Cowdry including body. I know that this body typical only for Herpesvirus. But in some articuls tells, thet Cowdry body`s found in adenovirus infection and in rats with roevirus?
Great app to help you study for hematology and clinical pathology. The app is free, features 70 plus level. Great for learning different red blood cell and white blood cell abnormal cells and more. https://play.google.com/store/apps/details?id=com.keywordpuzzles.microbiologyapp
Great app to help you study for microbiology, Medical Bacteriology. The app is free, features 70 plus level. Great for learning how to identify unknown organism, https://play.google.com/store/apps/details?id=com.keywordpuzzles.siteplatereading
Can anyone help me assess what this structure is from a H&E stained liver?
19 yr old not been to vet in over 10 yr, indoor only no other pets in house, no hx of trauma. Blood work norla albumin and tp normal left shift to wbc, non weight bearing, normal temp, pitting edema in lh foot, can see open draining area by medial tarsal area, sedate and shave found this.... vein is just cranial to this thickened string like piece of skin- nocardia, mycotic???
CALL FOR ABSTRACT: https://laboratorymedicine.conferenceseries.com/abstract-su… Event page : https://www.facebook.com/events/346954312424473/ Welcome to world wide disscussions on 13th International Conference on Laboratory Medicine and Pathology Laboratory Medicine and Pathology 2018 will be held in Berlin, Germany, Europe during June 25-26, 2018 hosted by Conferences Series LLC. The conference is organized with the theme "Excavating laboratory medicine in the era of automation, digitization and Informatics" please go through http://laboratorymedicine.conference/ Explore Berlin and gain knowledge on your Expertise. Great Opportunities are waiting for you. For more details, Visit : https://laboratorymedicine.conferenceseries.com/ Contact Person : Rachel Elizabeth || Program Director E-mail : [email protected] Contact number : 702-508-5200 Ext: 8036 WELCOME NOTE TO ORGANISATIONS ALL OVER WORLD.....!!!
CALL FOR ABSTRACT: https://laboratorymedicine.conferenceseries.com/abstract-su… Event page : https://www.facebook.com/events/346954312424473/ Welcome to world wide disscussions on 13th International Conference on Laboratory Medicine and Pathology Laboratory Medicine and Pathology 2018 will be held in Berlin, Germany, Europe during June 25-26, 2018 hosted by Conferences Series LLC. The conference is organized with the theme "Excavating laboratory medicine in the era of automation, digitization and Informatics" please go through http://laboratorymedicine.conference/ Explore Berlin and gain knowledge on your Expertise. Great Opportunities are waiting for you. For more details, Visit : https://laboratorymedicine.conferenceseries.com/ Contact Person : Rachel Elizabeth || Program Director E-mail : [email protected] Contact number : 702-508-5200 Ext: 8036 WELCOME NOTE TO ORGANISATIONS ALL OVER WORLD.....!!!
CONGRATS on making the list:
Laboratory Branch Manager Al Borg Laboratories Work Location: Helmia Branch Idfo Branch Mania El Qamah Branch-10 of Ramadan Branch Agaa Branch - Senbllaween Branch Fraskor Branch - Damietta Branch Kindly send your CV to: [email protected] Or Apply On:
I have a question......I had a cat with lymphoma. The cat dies in July of 2017. We worked with an Oncology vet as well as with members of the Cornell team. Every time we did a patho slide, which was about every 2 weeks,,,,for a 3 month period.....it came back different and inconclusive. Once there a small B cell proliferation......then mixed in the next slide,,,,,a month later.....large cells,,,,,,,,finally paraneoplastic eosinophilia.....Has anyone heard of something this insane ? The cat was on chemo drug Leukeran which worked essentially zero.....Every 3 weeks fluid would build up and she had to have it removed.