06/03/2026
How do genetics and diet work together to influence colorectal cancer risk?
A study led by Dr. Joel Sanchez-Mendez, a recent USC Population and Public Health Sciences (PPHS) PhD graduate, found that genetic variation in the TGF-β signaling pathway may help explain the relationship between red meat consumption and colorectal cancer risk. Analyzing data from more than 70,000 individuals, the research provides new insight into the biological mechanisms linking diet and cancer development.
The study also highlights innovative analytical methods developed by James Gauderman, PhD, leader of the Biostatistics Division within PPHS and a member of the USC Norris Comprehensive Cancer Center at Keck Medicine of USC's Cancer Epidemiology Program. The findings advance our understanding of how genetics and lifestyle factors interact to shape cancer risk and may help inform future prevention strategies.
Congratulations to Drs. Joel Sanchez-Mendez, James Gauderman, Mariana Stern, and the entire research team on this important work.
Full article available here:
AbstractBackground:. Red meat and/or processed meat are established colorectal cancer risk factors. Genome-wide association studies (GWAS) have reported more than 200 variants associated with colorectal cancer risk. We used functional annotation data to identify subsets of variants within known path...