Medical College of Wisconsin Cardiovascular Research Center

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Medical College of Wisconsin Cardiovascular Research Center From Discovery to Better Cardiovascular Health, Through Research, Innovation, and Education O. Smith Foundation, the Michael H.

The Cardiovascular Research Center, founded in 1992 at the Medical College of Wisconsin (MCW), is at the forefront of scientific discovery in cardiovascular health and disease, ranking in the top 10 in 2024 and the top 20 in the U.S. consistently during the last decade for federal dollars for cardiovascular research amongst medical schools. Over 32,000 square feet of space is dedicated to over 25 laboratories, housing offices, conference rooms, and equipment cores primarily located on the fourth floors of the Health Research Center and Medical Education Building. The Cardiovascular Research Center is situated in the heart of the Milwaukee Regional Medical Campus in Milwaukee, Wisconsin, which provides a unique immersive academic biomedical environment for cardiovascular education, research, and the healthcare of children and adults. The Cardiovascular Research Center’s mission is to lead discovery research and accelerate the translation of scientific breakthroughs for the prevention, diagnosis, and treatment of cardiovascular diseases. By building scientific bridges to clinical practice and training the next generation of cardiovascular researchers, we seek to revolutionize cardiovascular care and enhance public health across Wisconsin. More than 180 members of the Cardiovascular Research Center enjoy access to core equipment, specialized services, informative newsletters, pilot funding opportunities, and numerous seminars, events and courses for ongoing research education and trans-departmental networking to promote collaborative biomedical research, which are described in detail in following sections. Emphasis is placed on collaborative, multidisciplinary research centered around our members’ expertise in thematic areas of research called Signature Programs, which are 1) Atherosclerosis, Thrombosis & Vascular Biology, 2) Cardiac Biology & Heart Failure, 3) Cardio-Oncology, and 4) Hypertension. The Cardiovascular Research Center is directed by Mike Widlansky, MD, MPH, Northwestern Mutual Professor of Cardiovascular Medicine and Professor of Medicine and Pharmacology and Toxicology, who has over 20 years of experience and expertise leading cardiovascular clinical, training, and research programs. The Cardiovascular Research Center is supported by its three associate directors, Mary Sorci‐Thomas, PhD (Education & Training), Ze Zheng, MBBS, PhD (Basic Science), and Julie Freed, MD, PhD (Clinical & Translational Science); three assistant directors, Allison DeVan, PhD (Education & Training), Andrew Spearman, MD (Basic Science), and William Hughes, PhD (Clinical & Translational Science); and dedicated staff. Along with its exceptional leadership, the Cardiovascular Research Center receives extensive institutional support and thrives with philanthropic gifts by the A. Keelan, Jr., MD, Cardiovascular Research Fund, Sally Bentley Endowed Cardiovascular Venture Fund for New Researchers, Rupple Fund through the Greater Milwaukee Foundation, and the Cullen Family Healthy Heart Research Program, among others. For the past decade, the Cardiovascular Research Center has stewarded over $4.3M to train the next generation of researchers through its prestigious T32 postdoctoral training grant from the National Heart, Lung, and Blood Institute (NHLBI). In the last four years, the Center has also provided more than 40 summer undergraduate research fellowships, funded by the American Heart Association (AHA) Supporting Undergraduate Research Experience (SURE) and NHLBI R25, imparting training in career development and hands-on research experiences. For more information, visit: http://www.mcw.edu/Cardiovascular-Center.htm

Cardiovascular Research Center Member (CVRC), Elizabeth Sweeny, PhD, assistant professor of biochemistry has been named ...
10/07/2026

Cardiovascular Research Center Member (CVRC), Elizabeth Sweeny, PhD, assistant professor of biochemistry has been named the recipient of the 2026 Steve Cullen Healthy Heart Scholar Award for her project, “The Role of NADPH Oxidase in Canonical vs. Noncanonical NFkB Signaling in Atrial and Ventricular Cardiomyocytes.”

The atria and ventricles within the heart develop distinct pathologies (e.g., atrial fibrillation and left ventricular hypertrophy), but the roles of NADPH oxidase-induced oxidative stress, angiotensin, and NFkB signaling in these distinct heart chambers are not fully understood. This $50,000 award will support multidisciplinary research to determine how the expression and nuclear localization of different NADPH oxidases, a family of oxidative signaling enzymes, in atrial vs. ventricular cardiomyocytes contribute to angiotensin II-induced NFkB signaling. The funding will help Dr. Sweeny generate critical preliminary data to support a future NIH R01 grant application.

The Steve Cullen Healthy Heart Scholar Award is funded by the 2025 and 2026 Steve Cullen Healthy Heart Club Run/Walk events. Over the past 30 years, this annual event has raised more than $750,000 to advance cardiovascular research. The run honors the memory of former Milwaukee Alderman Steve Cullen, who died suddenly of a heart attack at age 40.

The 31st Annual Steve Cullen Healthy Heart Club Run/Walk will be held on February 13, 2027. https://cullenrun.com/

We are pleased to welcome our newest CVRC Member, Yang Xiao, MBBS, PhD, Assistant Professor in the Department of Physiol...
09/11/2026

We are pleased to welcome our newest CVRC Member, Yang Xiao, MBBS, PhD, Assistant Professor in the Department of Physiology. Dr. Xiao's research focuses on epigenetic regulation and inter-organ communication in cardiometabolic disease, using an integrated experimental and computational approach. She applies cutting-edge technologies including spatial and single-cell functional genomics, AAV-based mouse genetics and iPSC disease modelling to unbiasedly uncover novel mechanisms that can guide therapeutic development and disease prevention.

09/11/2026
The CVRC is happy to welcome our newest member, Stefano Schena, MD, PhD, Associate Professor in the Department of Surger...
09/09/2026

The CVRC is happy to welcome our newest member, Stefano Schena, MD, PhD, Associate Professor in the Department of Surgery, Division of Cardiothoracic Surgery. Dr. Schena's research interests include the utilization of robotic technology for the minimally invasive treatment of non-paroxysmal atrial fibrillation. He also uses the application of computational modeling to longitudinal assessment of bioprosthetic aortic valve failure, as well as studies the impact of bilateral intercostal nerve cryoablation on perioperative outcome of patients undergoing cardiac surgery via median sternotomy.

We are thrilled to share that CVRC Director, Michael Widlansky, MD, MPH, has been appointed Chief of the Division of Car...
09/08/2026

We are thrilled to share that CVRC Director, Michael Widlansky, MD, MPH, has been appointed Chief of the Division of Cardiovascular Medicine effective September 1, 2026. Dr. Widlansky has served as interim Division Chief since October 2025, leading the division through significant growth and development during that time. Over the past year, he has overseen the recruitment of 10 new faculty and a substantial increase in clinical productivity for the division in FY26. By securing philanthropic support, the cardiovascular fellowship program has expanded to include new research-intensive fellowship positions, and additional research opportunities have been generated through the creation of a unified philanthropic platform across the Division of Cardiovascular Medicine, the Heart and Vascular Service Line, and the Cardiovascular Research Center.

Dr. Widlansky joined MCW and the Department of Medicine as an Assistant Professor of Medicine and Pharmacology in 2007 and was promoted to Associate Professor in 2012 and to Professor in 2019. He holds the Northwestern Mutual Professorship in Cardiovascular Medicine and currently serves as Academic Chief in the Division of Cardiovascular Medicine and Director of the Cardiovascular Research Center, leading MCW’s work to improve cardiovascular health in southeast Wisconsin through cutting-edge research. He is also Director of the CTSI’s KL2 Program, co-directs MCW’s NIH-funded Physician-Scientist Training Program, and previously directed MCW’s Clinical and Translational Research Master's Program, underscoring his commitment to mentoring the next generation of physician-scientists.

Dr. Widlansky is a highly accomplished clinician and researcher whose work focuses on the mechanisms of vascular endothelial function in humans in both diseased and non-disease states in settings of observational studies and physiological clinical interventional trials. His work has been continuously funded by the NIH since 2009. His research has had a demonstrable impact on his field and has been recognized with several honors, including the Department of Medicine’s Michael J. Dunn Award for Research Excellence in 2021 and the Dean’s Award for Clinical and Translational Research in 2023. He serves as a Guest Editor for Vascular Medicine and on the editorial boards of Circulation and Circulation Research, and is a reviewer for multiple other high-impact journals. He also chaired the NIH’s Clinical Integrative Cardiovascular Sciences study section from 2019-2021. His bibliography includes more than 120 refereed journal publications, original papers, books, chapters, abstracts and reviews, and he frequently presents at local, regional, and national conferences as a key educator and thought leader in his field.

We are pleased to welcome our newest CVRC Member, Mary Eapen, MRCPI, MS, MBBS, Professor of Medicine in the Department o...
09/04/2026

We are pleased to welcome our newest CVRC Member, Mary Eapen, MRCPI, MS, MBBS, Professor of Medicine in the Department of Hematology & Oncology. She is also Senior Scientific Director - Research, Center for International Blood and Marrow Transplant Research. Her research focuses on the use of graft sources other than bone marrow for allogeneic hematopoietic cell transplantation for acute leukemia and marrow failure disorders.

The CVRC is pleased to welcome our newest member, Prithu Sundd, PHD, Professor in the Department of Biomedical Engineeri...
08/28/2026

The CVRC is pleased to welcome our newest member, Prithu Sundd, PHD, Professor in the Department of Biomedical Engineering. The Sundd labs primary focus is to understand the innate immune signaling contributing to thrombo-inflammation in the setting of sickle cell disease, hemophilia and influenza.

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