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10/13/2026

More than 80 years since autism’s first clinical description, researchers have built a wealth of information and scientific consensus around boys on the autism spectrum—but comparatively little is known about autistic girls.

It’s a matter of statistics, says James McPartland, PhD, Harris Professor in Yale Child Study Center and director of the Yale Center for Brain and Mind Health (CBMH). “Around the world, there are three or four boys diagnosed with autism for every girl,” he says. “So, when we do a study, we're learning 75% more about boys than girls.”

Historically, McPartland notes, that has also meant major gaps in diagnosis and care for autistic girls and women.

On Sept. 25, Yale CBMH and the Matthew Hillman Fisher Foundation gathered 22 researchers from across the United States and Europe in New Haven to pinpoint where those gaps exist and identify opportunities for future progress. They were joined by people with autism, caregivers, advocates, and others personally impacted by a condition that often goes undiagnosed or misdiagnosed in girls and women.

https://bit.ly/3VAKKPO

10/12/2026

Doctors have long known that genetics can trigger cancer. Now, new research shows genetics shape how cancer how behaves once it's there. Patients could have the same mutation but different reaction.

Here, we break down the science for you.

Smilow Cancer Hospital

10/11/2026

Yale researchers have unveiled a new imaging platform that can measure the metabolic activity of individual cells and identify their specific cell type, all within a single slice of intact human tissue. The method, called REDCAT (Raman Enhanced Delineation of Cell Atlases in Tissues), bridges a long-standing gap in biology by connecting what a cell is genetically programmed to do with its actual physical behavior.

Reported in the journal Nature Methods, the technology was developed by a collaborative team led by professors from Yale University, the University of California, San Diego, Columbia University, and the University of Pennsylvania.

"By combining technologies, REDCAT provides an exciting and powerful advance that allows users to connect cell type or state to metabolic function," said Allison Doerr, chief editor of Nature Methods.

Read here: https://bit.ly/4seFrln

10/10/2026

At Yale School of Medicine (YSM), physician-scientists are testing CAR-T (chimeric antigen receptor-T cell) therapy in clinical trials for autoimmune diseases including lupus, multiple sclerosis (MS), and scleroderma. Meanwhile, YSM basic science researchers are focused on better understanding how CAR-T therapy works—and how it can be improved.

Read here: https://bit.ly/4do3gRu

10/09/2026

YSM welcomes Tara Henderson, MD, MPH, who took the helm of the Department of Pediatrics on Oct. 1.

A pediatric oncologist, she has spent her career caring for children with cancer and studying the effects those early-life experiences have on her patients’ future health.

As chair, she aims to inspire the next generation of pediatricians, build connections, and harness the multidisciplinary, collaborative expertise at Yale to strengthen pediatric care now and into the future.

Get to know our new chair of Pediatrics: https://bit.ly/4s0jQwS

Yale Pediatrics

10/08/2026

Pathologists can struggle to correctly classify a certain type of tumor known as adenomyoepithelioma that can hide in plain sight among far more common, benign findings. However, a closer look at the tumor’s microscopic features, along with its distinctive molecular and genetic signatures, can improve how confidently doctors diagnose it, a new Yale School of Medicine study finds.

In the study, recently published in the American Journal of Surgical Pathology, researchers aimed to bring this often-misunderstood tumor into sharper focus. They evaluated several cases of adenomyoepithelioma of the breast that were classified into different categories. Upon closer review, however, 35% of cases were reclassified from their original diagnoses.

The findings, the researchers say, can inform how adenomyoepithelioma tumors are diagnosed going forward.

Read here: https://bit.ly/3VyOUaN

10/06/2026

Congratulations to Georg Nagel, Nobel Prize laureate in Physiology or Medicine.

We’re proud to celebrate Nagel’s remarkable achievement and his connection to Yale School of Medicine, where he completed his postdoctoral research. His groundbreaking work improved our understanding of cellular processes and laid the foundation for optogenetics.

10/05/2026

Amyloid cardiomyopathy is a disease caused by the buildup of misfolded proteins on the heart muscle. Left untreated, it can be deadly. But many patients only receive a diagnosis in its later stages after the onset of dangerous complications such as heart failure.

Now, Yale scientists have built an AI platform that doctors can access from their smartphones. It screens for the condition using images from electrocardiograms (ECG), a non-invasive test that measures the heart’s electrical activity. The platform - described recently in JAMA - can help doctors detect the disease more quickly and intervene before extensive heart damage occurs.

Read more here: https://bit.ly/4y1GpCA

10/03/2026

Ruth Montgomery, PhD, professor of medicine ( ) at Yale School of Medicine, and her colleagues recently described in Nature Immunology the technological developments and infrastructure investments that have changed the landscape of human immunology research. We’re now in a time in which researchers can use massive amounts of data to “predict disease risk, promote early diagnosis, and design interventions that promote health,” they write.

We talked to Montgomery about this new era of immunology and what it means for understanding disease and treating people.

Read here: https://bit.ly/3VlnLba

10/02/2026

Misophonia can cause intense feelings of distress, anger, or panic. This can happen when someone hears chewing, sniffing, tapping, or other .

“The response can feel immediate and involuntary, and some people avoid shared meals, classrooms, workplaces, or social situations to escape triggers,” comments Fernandez. He emphasizes that these feelings are real, even if others are not bothered by the same sounds.

It is important to know that is brain-based. Understanding this can help reduce blame, conflict at home, and misunderstandings at school or with friends.

Read more here: https://bit.ly/4AD8QJA

Yale Department of Psychiatry

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