08/28/2026
We’re excited to share a recent commentary on research led by our very own Gwenael Layec, PhD, and colleagues in Clinical Science!
Research from Gwenael Layec and colleagues investigating skeletal muscle oxygenation and energetics has been highlighted in a commentary by Graham J. Kemp, titled “Combined ³¹P and ¹H MRS show that impaired muscle O₂ supply limits ATP synthesis during exercise in systemic sclerosis.”
The commentary highlights the use of non-invasive magnetic resonance spectroscopy to better understand how impaired oxygen supply contributes to abnormal muscle energetics and exercise intolerance in systemic sclerosis.
Read the commentary here: https://portlandpress.com/clinsci/article/140/9/1953/237984/Combined-31P-and-1H-MRS-show-that-impaired-muscle
Abstract. Muscle weakness and fatigue feature in many diseases, but the underlying pathophysiology can be difficult to study in vivo. In patients with the chronic autoimmune disease systemic sclerosis (SSc), considerable disability results from small-vessel vasculopathy and progressive fibrosis. Alo...
