06/16/2026
New research from Carnegie Mellon University is reshaping how scientists understand Parkinson’s disease. Instead of a single condition, the study shows that key symptoms — tremor and slowed movement — arise from disruptions in different brain circuits.
Led by neuroscientist Aryn Gittis, the research identifies distinct patterns of neural activity in the motor thalamus, a central hub for movement control. These findings help explain why current treatments, which primarily target dopamine, work well for some symptoms but not others.
By mapping the specific circuits behind different symptoms, this work opens the door to more precise, personalized therapies and could improve approaches like deep brain stimulation. It also provides a new model for studying tremor, a long-standing challenge in Parkinson’s research.
Carnegie Mellon University’s Aryn Gittis and colleagues suggest the most recognizable symptoms of Parkinson's disease result from disruptions in different motor circuits of the brain, an insight that could help explain why current treatments don’t work equally for all patients.