10/08/2026
Congratulations to graduate alum Mary Brunkow *91, recipient of the 2026 Madison Medal, the top honor for Princeton University graduate alumni.
Last October, as we gathered for the Many Minds, Many Stripes conference to celebrate graduate alums, we learned Brunkow, a distinguished investigator at the Institute for Systems Biology in Seattle, was the 2025 Nobel Prize Laureate in Physiology or Medicine. Now, we look forward to welcoming her to Alumni Day, Sat., Feb. 20, 2027, to bestow the Madison Medal. Frances Arnold '79, 2018 Nobel laureate and engineering professor at Caltech, will receive the Woodrow Wilson Award, the top award for undergraduate alums.
“Mary Brunkow's trailblazing achievements illustrate the power of high-quality scientific research to deepen our understanding of human health and improve the prevention and treatment of disease,” said Princeton President Christopher L. Eisgruber '83. “Through her careful work, her transformative discoveries, and her exceptional career, she has demonstrated how collaboration, persistence, and curiosity can make a better world. She is a spectacular representative of the aspirations that define this University and its Graduate School.”
Brunkow, a member of the first graduate class of Princeton's new Department of Molecular Biology, was advised by former Princeton president Shirley Tilghman, then the Howard A. Prior Professor of the Life Sciences. Brunkow's Ph.D. research contributed to understanding genomic imprinting — the concept that a gene can be shut down depending on whether it was inherited from the mother or father.
In 2001, Brunkow and her colleagues at a biotechnology startup identified a mutated mouse gene linked to an autoimmune disease, a discovery that improved understanding of human immune function. Their research helped launch the field of peripheral immune tolerance — how the body prevents its own immune system from attacking healthy tissues and organs — and spurred medical advances. For this, Brunkow became the Princeton Graduate School's first alum to win the Nobel Prize in Physiology or Medicine, sharing the award with Fred Ramsdell and Shimon Sakaguchi.
Read more about Mary Brunkow and Frances Arnold: https://bit.ly/4ycrS7f
Princeton University Molecular Biology
Association of Princeton Graduate Alumni
Princeton Alumni
Nobel Prize