Oakland University Center for Biomedical Research

Oakland University Center for Biomedical Research The mission of the Center for Biomedical Research is to vigorously promote and support biomedical research and education at Oakland University
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Biomedical Research has given us all a wonderful gift: The Covid-19 vaccine! OU students should take advantage of it on ...
04/08/2021
COVID-19 Vaccines - Grizzlies Protect Grizzlies - Oakland University

Biomedical Research has given us all a wonderful gift: The Covid-19 vaccine! OU students should take advantage of it on April 13, between 9 and 4:30, at the OU Rec Center. Bring your OU ID.

https://www.oakland.edu/return-to-campus/covid-19-vaccines/

The goal is for every member of the OU community to receive a vaccination before the end of spring semester, and to ensure that all students, faculty and staff are completely immunized before the start of fall semester.

Biomedical Research would grind to a halt without help from the Oakland University Library. Happy National Library Worke...
04/06/2021
National Library Workers Day: Libraries work because we do!

Biomedical Research would grind to a halt without help from the Oakland University Library. Happy National Library Workers Day! https://ala-apa.org/nlwd/

While we cannot have in-person celebrations, it is still a good time to highlight the critical role library workers play in keeping our libraries running. How about taking our celebrations online? Let’s take this time to flood social media (using the hashtag #NLWD21) with words of gratitude for al...

04/01/2021
Oakland University Medical Physics PhD Program
03/12/2021

Oakland University Medical Physics PhD Program

Yesterday, Dilmini Wijesinghe successfully defended her PhD dissertation "Impacts of Anisotropy on Cardiac Mechanotransduction--Computation Based Mathematical Modeling Using the Mechanical Bidomain Model." Congratulations Dilmini!

OU undergrad physics alum Vanessa Puñal is named a 2020 Howard Hughes Medical Institute Hanna Gray Fellow. Congratulatio...
02/19/2021
HHMI Commits $30 Million to Increase Diversity in Science with 21 Hanna Gray Fellows

OU undergrad physics alum Vanessa Puñal is named a 2020 Howard Hughes Medical Institute Hanna Gray Fellow. Congratulations Vanessa! https://www.hhmi.org/news/hhmi-commits-30-million-to-increase-diversity-in-science-with-21-hanna-gray-fellows

HHMI announces the selection of 21 exceptional early career scientists as 2020 Hanna Gray Fellows to support diversity in biomedical research. The 2022 Hanna H. Gray Fellows Program competition will open later this year.

Below I quote the last paragraph of Walter Isaacson's article "The Race to Save the World," published in the January 18/...
02/11/2021
How mRNA Technology Could Upend the Drug Industry

Below I quote the last paragraph of Walter Isaacson's article "The Race to Save the World," published in the January 18/25 issue of TIME magazine. It's one of the best arguments for basic research I've ever read.

"The invention of easily reprogrammable RNA vaccines was a lightning-fast triumph of human ingenuity, but it was based on decades of curiosity-driven research into one of the most fundamental aspects of life on planet earth: how genes are transcribed into RNA that tell cells what proteins to assemble. Likewise, CRISPR gene-editing technology came from understanding the way that bacteria use snippets of RNA to guide enzymes to destroy viruses. Great inventions come from understanding basic science. Nature is beautiful that way."

https://time.com/5927342/mrna-covid-vaccine/

Inside the remarkable scientific discoveries behind the new COVID-19 vaccines

CBR member Xiangqun Zeng, of the Department of Chemistry, speaking to the Celebration of the International Day ofWomen a...
02/11/2021

CBR member Xiangqun Zeng, of the Department of Chemistry, speaking to the Celebration of the International Day of
Women and Girls in Science in Rabat, Morocco. #InternationalDayOfWomenInScience

OU’s Xiangqun Zeng to speak at international celebration of women and girls in science - 2021 - Department of Chemistry ...
02/08/2021
OU’s Xiangqun Zeng to speak at international celebration of women and girls in science - 2021 - Department of Chemistry - OU Magazine - News - Oakland University

OU’s Xiangqun Zeng to speak at international celebration of women and girls in science - 2021 - Department of Chemistry - OU Magazine - News - Oakland University

Xiangqun Zeng, distinguished professor of analytical chemistry, was invited to give a talk during a virtual celebration of the International Day of Women and Girls in Science. The February 11 event is hosted by the Islamic World Educational, Scientific and Cultural Organization (ICESCO), in collabor...

Oakland University Center for Biomedical Research
02/02/2021

Oakland University Center for Biomedical Research

Bioengineering at Oakland University
01/26/2021

Bioengineering at Oakland University

Undergraduate students with interest in cardiovascular research take advantage of this opportunity at Oakland University during this summer!!

Grants in Aid of Research Recipient Profile: Dominic Mier
01/14/2021
Grants in Aid of Research Recipient Profile: Dominic Mier

Grants in Aid of Research Recipient Profile: Dominic Mier

News Archive Grants in Aid of Research Recipient Profile: Dominic Mier December 22, 2020 Grant: $1,000 in Spring 2019 Education level at time of the grant: Graduate student  Project Description: In the lab Dominic studies the minor spliceosome. The spliceosome is in charge of removing noncoding int...

Ukraine genome survey adds missing pieces to human diversity puzzle
01/13/2021
Ukraine genome survey adds missing pieces to human diversity puzzle

Ukraine genome survey adds missing pieces to human diversity puzzle

The largest study of genetic diversity in Ukraine was published in the open science journal GigaScience. Led by researchers at Uzhhorod National University and Oakland University in the US, the work provides genetic understanding of the historic and pre-historic migration settlements in one o...

The 2021 Michigan Academy of Science, Arts & Letters Conference will be held Friday, March 12, hosted virtually in colla...
01/05/2021

The 2021 Michigan Academy of Science, Arts & Letters Conference will be held Friday, March 12, hosted virtually in collaboration between Alma College and Andrews University. You are invited to submit a 200 word abstract. The deadline is January 15, 2021.

Organic Matter Decomposition and Ecosystem Metabolism as Tools to Assess the Functional Integrity of Streams and Rivers—...
12/15/2020
Organic Matter Decomposition and Ecosystem Metabolism as Tools to Assess the Functional Integrity of Streams and Rivers—A Systematic Review

Organic Matter Decomposition and Ecosystem Metabolism as Tools to Assess the Functional Integrity of Streams and Rivers—A Systematic Review

Streams and rivers provide important services to humans, and therefore, their ecological integrity should be a societal goal. Although ecological integrity encompasses structural and functional integrity, stream bioassessment rarely considers ecosystem functioning. Organic matter decomposition and e...

11/24/2020
Oakland University

Listen to OU Philosophy Professor Mark Navin being interviewed about the ethics of vaccines, with particular attention to the new COVID-19 vaccines. Mark' segment runs from about 20:00 to 60:00. Fascinating stuff.
https://www.facebook.com/oaklandu/videos/374884910261549

Dr. Mark Navin, Ph.D., Chair of Philosophy and Lecturer in Foundational Medical Studies at Oakland University William Beaumont School of Medicine, discusses the philosophical and ethical rationale for refusing treatment to families that refuse to take vaccines, and how a refusal from some families to receive the COVID-19 vaccine could impact medical care in the months following distribution on a large-scale to the population.

Matt Cannon, Spokesperson for The Hub, joins the show to talk about the programs provided by the company, and how this interesting business has modified its operations for COVID-19 safety.

Mayor Ethan Baker from the City of Troy talks about the City's continued response to COVID-19, as well as how Troy is helping its strong business community weather the three-week "pause" initiated by the Michigan Department of Health and Human Services.

Darienne Hudson, President and CEO for United Way of Southeastern Michigan, discusses why support for non-profits like the United Way is even more important during a pandemic, and how the needs of United Way and organizations like it have been altered by the longevity of the COVID-19 pandemic.

Gerry McCallum, Director of City Services for the City of Orchard Lake Village, talks about the City's operations during the pandemid, including how the financial impacts of COVID-19 are being mitigated in City budgets. Additionally, he discusses the recent memorial for the late, long-time City Clerk, Janet Overholt Green.

For more local news and information about COVID-19 and other top stories, visit civiccentertv.com/coronavirus and watch clips, interviews and full episodes of the Oakland county Megacast at civiccentertv.com/megacast.

Providing news and information to the Oakland County area, the Oakland County Megacast features guests including municipal and public safety leadership, medical experts, businesses and community organizations and civilians in order to tell the stories of our community.

11/11/2020
Join our Cloud HD Video Meeting

"Being a graduate student is tough. Being a graduate student during a pandemic is another story."

Self Care Workshop: 2020 Edition
November 19, 12-1PM
Login via Zoom: https://us02web.zoom.us/j/89883710514

In this workshop, Cortney Heileman of University Recreation and Well-Being will lead a conversation on the importance of emotional wellness during these unpredictable times. Using the tips and strategies provided, creating balance among the different responsibilities graduate students face can be possible!

Zoom is the leader in modern enterprise video communications, with an easy, reliable cloud platform for video and audio conferencing, chat, and webinars across mobile, desktop, and room systems. Zoom Rooms is the original software-based conference room solution used around the world in board, confer...

The Michigan Academy of Sciences, Arts, and Letters conference will be held on March 12, 2021. Its a great chance to dis...
11/11/2020

The Michigan Academy of Sciences, Arts, and Letters conference will be held on March 12, 2021. Its a great chance to discuss your research.

Eye Research Institute
11/10/2020

Eye Research Institute

Please message us for a link for our next Kinsey Seminar, NOW on Wednesday, November 18th

11/10/2020
Bioengineering at Oakland University

Bioengineering at Oakland University

Congratulations to Suraj Timilsina, graduate student in the Villa-Diaz lab for his award in the category of Cell Biology and Biochemistry Graduate Division during the 2020 @SigmaXiSociety Annual Meeting and Student Research Conference. Here his work:

11/10/2020
Oakland University Department of Biological Sciences

Oakland University Department of Biological Sciences

Congratulation to Krystina Shchubelka and Walter Wolfsberger, graduate students in our Department for their award in the Sigma Xi Annual Meeting and Student Research Conference in the category of Interdiscliplinary Research Graduate Division

Undergrad STEM majors: Apply for the Goldwater Scholarship. OU deadline is Jan 6, 2021. Contact Brad Roth (roth@oakland....
11/07/2020

Undergrad STEM majors: Apply for the Goldwater Scholarship. OU deadline is Jan 6, 2021. Contact Brad Roth ([email protected]) of see the flier for details.

Former graduate student Afua Yorke (PhD, Medical Physics, 2019) was lead author on a recently published article based on...
10/30/2020
A feasibility study to estimate optimal rigid‐body registration using combinatorial rigid registration optimization (CORRO)

Former graduate student Afua Yorke (PhD, Medical Physics, 2019) was lead author on a recently published article based on her dissertation research. Her advisor and senior author is Thomas Guerrero of the Department of Radiation Oncology at Beaumont Hospital in Royal Oak, Michigan. Guerrero is an adjunct faculty member in the Department of Physics at Oakland University. David Solis, formerly at Beaumont, also contributed.

The article, titled “A feasibility Study to Estimate Optimal Rigid-Body Registration Using Combinatorial Rigid Registration Optimization (CORRO),” is available for early access at the Journal of Applied Clinical Medical Physics (https://aapm.onlinelibrary.wiley.com/doi/10.1002/acm2.12965). The abstract is given below.

Purpose Clinical image pairs provide the most realistic test data for image registration evaluation. However, the optimal registration is unknown. Using combinatorial rigid registration optimization (CORRO) we demonstrate a method to estimate the optimal alignment for rigid-registration of clinical image pairs. Methods Expert selected landmark pairs were selected for each CT/CBCT image pair for six cases representing head and neck, thoracic, and pelvic anatomic regions. Combination subsets of a k number of landmark pairs (k-combination set) were generated without repeat to form a large set of k-combination sets (k-set) for k = 4,8,12. The rigid transformation between the image pairs was calculated for each k-combination set. The mean and standard deviation of these transformations were used to derive final registration for each k-set. Results The standard deviation of registration output decreased as the k-size increased for all cases. The joint entropy evaluated for each k-set of each case was smaller than those from two commercially available registration programs indicating a stronger correlation between the image pair after CORRO was used. A joint histogram plot of all three algorithms showed high correlation between them. As further proof of the efficacy of CORRO the joint entropy of each member of 30 000 k-combination sets in k = 4 were calculated for one of the thoracic cases. The minimum joint entropy was found to exist at the estimated mean of registration indicating CORRO converges to the optimal rigid-registration results. Conclusions We have developed a methodology called CORRO that allows us to estimate optimal alignment for rigid-registration of clinical image pairs using a large set landmark point. The results for the rigid-body registration have been shown to be comparable to results from commercially available algorithms for all six cases. CORRO can serve as an excellent tool that can be used to test and validate rigid registration algorithms.

Purpose Clinical image pairs provide the most realistic test data for image registration evaluation. However, the optimal registration is unknown. Using combinatorial rigid registration optimization...

CBR member Evgeniy Khain, of the Department of Physics, recently published an article about Two-Level Modeling of Quaran...
09/23/2020
Two-level modeling of quarantine

CBR member Evgeniy Khain, of the Department of Physics, recently published an article about Two-Level Modeling of Quarantine in Physical Review E (Volume 102, Article Number 022313). The paper is relevant to our experiences during the quarantine caused by Covid-19. The abstract is given below.

Continuum models of epidemics do not take into account the underlying microscopic network structure of social connections. This drawback becomes extreme during quarantine when most people dramatically decrease their number of social interactions, while others (like cashiers in grocery stores) continue maintaining hundreds of contacts per day. We formulate a two-level model of quarantine. On a microscopic level, we model a single neighborhood assuming a star-network structure. On a mesoscopic level, the neighborhoods are placed on a twodimensional lattice with nearest-neighbors interactions. The modeling results are compared with the COVID-19 data for several counties in Michigan (USA) and the phase diagram of parameters is identified.

https://journals.aps.org/pre/abstract/10.1103/PhysRevE.102.022313

Continuum models of epidemics do not take into account the underlying microscopic network structure of social connections. This drawback becomes extreme during quarantine when most people dramatically decrease their number of social interactions, while others (like cashiers in grocery stores) contin...

Thanks to all OU reviewers. Peer review is at the heart of science. Every time you review a paper or grant proposal, you...
09/23/2020
Peer Review Week

Thanks to all OU reviewers. Peer review is at the heart of science. Every time you review a paper or grant proposal, you make a contribution.

Peer Review Week is a global event celebrating the essential role that peer review plays in maintaining scientific quality.

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Hello Oakland University! We are hiring medical scribes and medical assistants! No experience required. Must be pursuing pre-medicine or have completed pre-medical coursework. Email us your resume at [email protected]
Down in Puerto Rico at the International Mammalian Genome Conference. Thanks to the world-class faculty, attendees, and organizers for making the conference such a great event. We are making great advances in the field of mouse genetics, which has ultimately led to discovering innovative ways to treat human disease. I was fortunate enough to win the Outstanding Nomenclature Award on my poster, which would not have been possible without the help and mentorship of Dr. Amy Siebert-McKenzie and Dr. Randal Westrick. Dr. Siebert has been an instrumental part of the Westrick lab, and the platelet PAI-1 project. #scientists #genomics #genetics #mouse #nomenclature #mammalian #award