09/09/2026
Drs. Annette Fleckenstein and Glen Hanson were co-authors in the study, "Differential Effects of Neurotensin NTS1 and NTS2 Receptors on Locomotion," published in the journal Brain and Behavior.
https://pmc.ncbi.nlm.nih.gov/articles/PMC12617275/
The study examined how two neurotensin receptors, NTS1 and NTS2, influence movement, exploration, and responses to ni****ne in mice. Researchers found that mice lacking the NTS1 receptor adapted more slowly to a new environment, while mice lacking the NTS2 receptor adapted more quickly than normal mice. Ni****ne reduced movement and exploratory activity in normal mice and in mice without NTS1, but had little effect on mice without NTS2. These findings suggest that the two receptors play opposite roles in regulating dopamine-related brain activity and behavior. The results also indicate that ni****ne may increase neurotensin signaling through NTS1 receptors, helping animals become accustomed to new surroundings more quickly.
