10/23/2026
This , please join us in congratulating Associate Professors of Biology Megan Povelones, PhD, and Michael Povelones, PhD, on being awarded a $2,319,953 National Institutes of Health R01 research grant!
The five-year project investigates how a group of single-celled parasites called kinetoplastids sense their environment, attach to insect tissue and transition between developmental stages critical for disease transmission. Although the diseases these parasites cause affect millions of individuals worldwide, certain aspects of how the parasites survive within insect hosts and prepare for transmission remain poorly understood.
"All of these parasites depend on insects to complete their life cycle," says Dr. Megan Povelones. "To stop transmission, we first need to understand the biological mechanisms that allow parasites to survive, develop and move between hosts."
The researchers have developed a model system using Crithidia fasciculata, a parasite that naturally infects mosquitoes but shares many biological characteristics with its human disease-causing relatives. Utilizing a new mosquito insectary on campus that supports studies of insect-host interactions and vector-borne disease biology, they will be able to observe the parasite’s behavior in real time and manipulate conditions as they study these biological processes.
"This project is really about understanding how a single event, attachment, can completely reprogram a cell," explains Dr. Michael Povelones. "The parasite senses something about its environment, attaches and then fundamentally changes its biology to survive in a new setting. We're working to identify the signals and pathways that drive that transformation."
The researchers hope their findings will contribute to broader efforts to combat neglected vector-borne diseases.
"Many of these diseases disproportionately affect some of the world's most vulnerable populations," adds Dr. Megan Povelones. "By understanding these fundamental biological processes, we may ultimately help create opportunities for new intervention strategies that prevent infection before it starts."